Evaluation of diffusion time–dependent changes in radial diffusivity as a surrogate for axon diameter.
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| Title: | Evaluation of diffusion time–dependent changes in radial diffusivity as a surrogate for axon diameter. |
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| Authors: | Alderson, Hannah E.1,2 (AUTHOR), Does, Mark D.1,2,3,4 (AUTHOR), Hutchinson, Elizabeth B.5 (AUTHOR), Harkins, Kevin D.1,2,4 (AUTHOR) kevin.d.harkins@vumc.org |
| Source: | Magnetic Resonance in Medicine. Sep2025, Vol. 94 Issue 3, p1248-1256. 9p. |
| Subjects: | Scanning electron microscopy, Spinal cord, Myelin, Axons, Magnetic resonance imaging |
| Abstract: | Purpose: To experimentally evaluate the change in radial diffusivity with diffusion time (∆D⊥$$ \Delta {\mathrm{D}}_{\perp } $$) as a simple estimate of axon diameter. Methods: Ex vivo ferret spinal cords were imaged via MRI and scanning electron microscopy. Region‐of‐interest comparisons were made between ∆D⊥$$ \Delta {\mathrm{D}}_{\perp } $$ and area‐weighted mean axon diameter, deff$$ \left\langle {\mathrm{d}}_{\mathrm{eff}}\right\rangle $$, derived from scanning electron microscopy. Additional comparisons were made between ∆D⊥$$ \Delta {\mathrm{D}}_{\perp } $$ and quantitative MRI myelin metrics. Results: A strong linear correlation was found between ∆D⊥$$ \Delta {\mathrm{D}}_{\perp } $$ and deff$$ \left\langle {\mathrm{d}}_{\mathrm{eff}}\right\rangle $$. Negative correlations were found between myelin water fraction and ∆D⊥$$ \Delta {\mathrm{D}}_{\perp } $$ as well as bound pool fraction and ∆D⊥$$ \Delta {\mathrm{D}}_{\perp } $$. Conclusion: The value of ∆D⊥$$ \Delta {\mathrm{D}}_{\perp } $$ is shown to be a good estimate of axon size in ex vivo spinal cords regardless of variations in myelin content, as indicated by quantitative MRI. [ABSTRACT FROM AUTHOR] |
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| Database: | Engineering Source |
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