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3D virtual biopsy of in vivo pH and metabolism using PRESS and semi‐LASER MRS of hyperpolarized 13C nuclei.

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Title: 3D virtual biopsy of in vivo pH and metabolism using PRESS and semi‐LASER MRS of hyperpolarized 13C nuclei.
Authors: Gottwald, Wolfgang1 (AUTHOR), Nagel, Luca1 (AUTHOR), Grashei, Martin1 (AUTHOR), Bauer, Sebastian1 (AUTHOR), Setzer, Nadine1 (AUTHOR), Gaksch, Florian1,2 (AUTHOR), Sühnel, Sandra1 (AUTHOR), Skinner, Jason G.1 (AUTHOR), Braren, Rickmer3,4 (AUTHOR), Heid, Irina3 (AUTHOR), Topping, Geoffrey J.1 (AUTHOR), Schilling, Franz1,4,5 (AUTHOR) fschilling@tum.de
Source: Magnetic Resonance in Medicine. Sep2025, Vol. 94 Issue 3, p880-894. 15p.
Subjects: Nuclear magnetic resonance spectroscopy, Pancreatic duct, Pyruvates, Adenocarcinoma, Kidneys
Abstract: Purpose: To develop and evaluate sequences for multi‐voxel magnetic resonance spectroscopy using hyperpolarized molecules. Methods: A standard single voxel PRESS sequence was extended to acquire multiple voxels consecutively. Its SNR was compared against a 2D FID‐CSI with both 1H and hyperpolarized 13C nuclei in phantoms and in a healthy mouse at 7T. This sequence was also used to determine tumor pH and metabolic activity in an endogenous murine pancreatic ductal adenocarcinoma model. Furthermore, a semi‐LASER sequence, using adiabatic full passage RF pulses for refocusing, was implemented. Multi‐voxel PRESS and semi‐LASER were then compared in healthy mice for measuring metabolic activity and pH using hyperpolarized [1‐13C]pyruvate and [1,5‐13C2]Z‐OMPD, respectively. Results: Multi‐voxel PRESS and semi‐LASER detected 13C metabolites in mouse kidneys and endogenous pancreatic ductal adenocarcinoma (PDAC) tumors with SNR comparable to that of standard 2D FID‐CSI. They enable fast MRS with a high spectral resolution that is highly customizable to recover spectra from regions not coverable by a single CSI slice. Conclusion: For the first time, we show hyperpolarized MRS using multi‐voxel PRESS and semi‐LASER sequences for hyperpolarized 13C‐labeled molecules. By implementing a semi‐LASER sequence using adiabatic full passage refocusing pulses, RF saturation was reduced. Semi‐LASER allows flexible overlapping of voxel refocusing planes, while for PRESS, signal from these regions is attenuated. [ABSTRACT FROM AUTHOR]
Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: 3D virtual biopsy of in vivo pH and metabolism using PRESS and semi‐LASER MRS of hyperpolarized <superscript>13</superscript>C nuclei.
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  Data: <searchLink fieldCode="AR" term="%22Gottwald%2C+Wolfgang%22">Gottwald, Wolfgang</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nagel%2C+Luca%22">Nagel, Luca</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Grashei%2C+Martin%22">Grashei, Martin</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bauer%2C+Sebastian%22">Bauer, Sebastian</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Setzer%2C+Nadine%22">Setzer, Nadine</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gaksch%2C+Florian%22">Gaksch, Florian</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sühnel%2C+Sandra%22">Sühnel, Sandra</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Skinner%2C+Jason+G%2E%22">Skinner, Jason G.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Braren%2C+Rickmer%22">Braren, Rickmer</searchLink><relatesTo>3,4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Heid%2C+Irina%22">Heid, Irina</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Topping%2C+Geoffrey+J%2E%22">Topping, Geoffrey J.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Schilling%2C+Franz%22">Schilling, Franz</searchLink><relatesTo>1,4,5</relatesTo> (AUTHOR)<i> fschilling@tum.de</i>
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  Data: <searchLink fieldCode="JN" term="%22Magnetic+Resonance+in+Medicine%22">Magnetic Resonance in Medicine</searchLink>. Sep2025, Vol. 94 Issue 3, p880-894. 15p.
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  Data: <searchLink fieldCode="DE" term="%22Nuclear+magnetic+resonance+spectroscopy%22">Nuclear magnetic resonance spectroscopy</searchLink><br /><searchLink fieldCode="DE" term="%22Pancreatic+duct%22">Pancreatic duct</searchLink><br /><searchLink fieldCode="DE" term="%22Pyruvates%22">Pyruvates</searchLink><br /><searchLink fieldCode="DE" term="%22Adenocarcinoma%22">Adenocarcinoma</searchLink><br /><searchLink fieldCode="DE" term="%22Kidneys%22">Kidneys</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Purpose: To develop and evaluate sequences for multi‐voxel magnetic resonance spectroscopy using hyperpolarized molecules. Methods: A standard single voxel PRESS sequence was extended to acquire multiple voxels consecutively. Its SNR was compared against a 2D FID‐CSI with both 1H and hyperpolarized 13C nuclei in phantoms and in a healthy mouse at 7T. This sequence was also used to determine tumor pH and metabolic activity in an endogenous murine pancreatic ductal adenocarcinoma model. Furthermore, a semi‐LASER sequence, using adiabatic full passage RF pulses for refocusing, was implemented. Multi‐voxel PRESS and semi‐LASER were then compared in healthy mice for measuring metabolic activity and pH using hyperpolarized [1‐13C]pyruvate and [1,5‐13C2]Z‐OMPD, respectively. Results: Multi‐voxel PRESS and semi‐LASER detected 13C metabolites in mouse kidneys and endogenous pancreatic ductal adenocarcinoma (PDAC) tumors with SNR comparable to that of standard 2D FID‐CSI. They enable fast MRS with a high spectral resolution that is highly customizable to recover spectra from regions not coverable by a single CSI slice. Conclusion: For the first time, we show hyperpolarized MRS using multi‐voxel PRESS and semi‐LASER sequences for hyperpolarized 13C‐labeled molecules. By implementing a semi‐LASER sequence using adiabatic full passage refocusing pulses, RF saturation was reduced. Semi‐LASER allows flexible overlapping of voxel refocusing planes, while for PRESS, signal from these regions is attenuated. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1002/mrm.30544
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      – Code: eng
        Text: English
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      – SubjectFull: Nuclear magnetic resonance spectroscopy
        Type: general
      – SubjectFull: Pancreatic duct
        Type: general
      – SubjectFull: Pyruvates
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      – SubjectFull: Adenocarcinoma
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      – TitleFull: 3D virtual biopsy of in vivo pH and metabolism using PRESS and semi‐LASER MRS of hyperpolarized 13C nuclei.
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              Text: Sep2025
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