Multi‐compartment metabolic assessment of the kidneys by co‐hyperpolarized 13C MRI.
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| Title: | Multi‐compartment metabolic assessment of the kidneys by co‐hyperpolarized 13C MRI. |
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| Authors: | von Morze, Cornelius1 (AUTHOR) cornelius@wustl.edu, Shaw, Ashley1 (AUTHOR), Shoghi, Kooresh I.1 (AUTHOR), Blazey, Tyler1 (AUTHOR) |
| Source: | Magnetic Resonance in Medicine. Sep2025, Vol. 94 Issue 3, p905-912. 8p. |
| Subjects: | Polarization (Nuclear physics), Biomarkers, Biochemical substrates, Kidney physiology, Kidney diseases |
| Abstract: | Purpose: The purpose of this study was to show that hyperpolarized (HP) carbon‐13 (13C) MRI with multiple co‐HP substrates can probe the time course of renal metabolic changes in diabetes. Methods: [1‐13C]pyruvate and [1,3‐13C2]acetoacetate were co‐HP for simultaneous metabolic assessment of cytosolic and mitochondrial compartments, respectively. A custom multi‐band spectral–spatial radiofrequency pulse was designed for enhanced detection of downstream metabolites of both substrates. In vivo co‐HP 13C kidney spectra were acquired serially in rats with uncontrolled insulin‐deficient diabetes over a period of 8 weeks. Time courses of changes in apparent metabolic conversions of [1‐13C]pyruvate and [1,3‐13C2]acetoacetate were evaluated and compared with routine clinical markers of kidney disease obtained by serum and urine sampling. Results: Metabolic conversions of both co‐HP substrates showed large shifts in diabetic kidney with chronic hyperglycemia. Production of both HP [1‐13C]lactate and [1,3‐13C2]β‐hydroxybutyrate increased over time, with β‐hydroxybutyrate signal significantly elevated at 4 weeks, sustained at 8 weeks. Lactate trended higher at 4 weeks, with a larger, significant increase at 8 weeks. Serum and urine markers of renal function were unaltered from baseline throughout the time course, without significant change in serum creatinine nor evidence of albuminuria. Conclusion: Noninvasive 13C MRI using multiple co‐HP metabolic substrates, whose activities are localized to distinct cellular compartments, could enable early detection of diabetic kidney damage. [ABSTRACT FROM AUTHOR] |
| Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
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| Header | DbId: egs DbLabel: Engineering Source An: 186342856 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Multi‐compartment metabolic assessment of the kidneys by co‐hyperpolarized <superscript>13</superscript>C MRI. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22von+Morze%2C+Cornelius%22">von Morze, Cornelius</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> cornelius@wustl.edu</i><br /><searchLink fieldCode="AR" term="%22Shaw%2C+Ashley%22">Shaw, Ashley</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Shoghi%2C+Kooresh+I%2E%22">Shoghi, Kooresh I.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Blazey%2C+Tyler%22">Blazey, Tyler</searchLink><relatesTo>1</relatesTo> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Magnetic+Resonance+in+Medicine%22">Magnetic Resonance in Medicine</searchLink>. Sep2025, Vol. 94 Issue 3, p905-912. 8p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Polarization+%28Nuclear+physics%29%22">Polarization (Nuclear physics)</searchLink><br /><searchLink fieldCode="DE" term="%22Biomarkers%22">Biomarkers</searchLink><br /><searchLink fieldCode="DE" term="%22Biochemical+substrates%22">Biochemical substrates</searchLink><br /><searchLink fieldCode="DE" term="%22Kidney+physiology%22">Kidney physiology</searchLink><br /><searchLink fieldCode="DE" term="%22Kidney+diseases%22">Kidney diseases</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Purpose: The purpose of this study was to show that hyperpolarized (HP) carbon‐13 (13C) MRI with multiple co‐HP substrates can probe the time course of renal metabolic changes in diabetes. Methods: [1‐13C]pyruvate and [1,3‐13C2]acetoacetate were co‐HP for simultaneous metabolic assessment of cytosolic and mitochondrial compartments, respectively. A custom multi‐band spectral–spatial radiofrequency pulse was designed for enhanced detection of downstream metabolites of both substrates. In vivo co‐HP 13C kidney spectra were acquired serially in rats with uncontrolled insulin‐deficient diabetes over a period of 8 weeks. Time courses of changes in apparent metabolic conversions of [1‐13C]pyruvate and [1,3‐13C2]acetoacetate were evaluated and compared with routine clinical markers of kidney disease obtained by serum and urine sampling. Results: Metabolic conversions of both co‐HP substrates showed large shifts in diabetic kidney with chronic hyperglycemia. Production of both HP [1‐13C]lactate and [1,3‐13C2]β‐hydroxybutyrate increased over time, with β‐hydroxybutyrate signal significantly elevated at 4 weeks, sustained at 8 weeks. Lactate trended higher at 4 weeks, with a larger, significant increase at 8 weeks. Serum and urine markers of renal function were unaltered from baseline throughout the time course, without significant change in serum creatinine nor evidence of albuminuria. Conclusion: Noninvasive 13C MRI using multiple co‐HP metabolic substrates, whose activities are localized to distinct cellular compartments, could enable early detection of diabetic kidney damage. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/mrm.30568 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 8 StartPage: 905 Subjects: – SubjectFull: Polarization (Nuclear physics) Type: general – SubjectFull: Biomarkers Type: general – SubjectFull: Biochemical substrates Type: general – SubjectFull: Kidney physiology Type: general – SubjectFull: Kidney diseases Type: general Titles: – TitleFull: Multi‐compartment metabolic assessment of the kidneys by co‐hyperpolarized 13C MRI. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: von Morze, Cornelius – PersonEntity: Name: NameFull: Shaw, Ashley – PersonEntity: Name: NameFull: Shoghi, Kooresh I. – PersonEntity: Name: NameFull: Blazey, Tyler IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 09 Text: Sep2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 07403194 Numbering: – Type: volume Value: 94 – Type: issue Value: 3 Titles: – TitleFull: Magnetic Resonance in Medicine Type: main |
| ResultId | 1 |
