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Organocatalytic Enantioselective Conjugate Addition of Isoxazol‐5(4H)‐Ones to Aurone‐Derived Azadienes.

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Title: Organocatalytic Enantioselective Conjugate Addition of Isoxazol‐5(4H)‐Ones to Aurone‐Derived Azadienes.
Authors: Torán, Ricardo1 (AUTHOR), Torró, Jordi1 (AUTHOR), Sanz‐Marco, Amparo1 (AUTHOR) amparo.sanz-marco@uv.es, Vila, Carlos1 (AUTHOR), Blay, Gonzalo1 (AUTHOR) gonzalo.blay@uv.es
Source: ChemCatChem. 6/23/2025, Vol. 17 Issue 12, p1-5. 5p.
Subjects: Organocatalysis, Conjugate addition reactions, Stereoselective reactions, Azaarenes, Benzofuran, Isoxazoles, Chiral drugs, Aurones
Abstract: An efficient enantioselective organocatalytic conjugate addition of isoxazol‐5(4H)‐ones to aurone‐derived azadienes under mild conditions has been developed. This methodology provides access to a wide range of chiral compounds featuring both benzofuran and isoxazole scaffolds in their structures achieving high yields and stereo control. Furthermore, the resulting adducts can be readily transformed into chiral β‐benzofuran‐branched carbonyl compounds in high yields and enantioselectivity in one‐pot reaction through hydrolysis‐decarboxylation of the isoxazole ring. [ABSTRACT FROM AUTHOR]
Copyright of ChemCatChem is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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Header DbId: egs
DbLabel: Engineering Source
An: 186461225
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PubType: Academic Journal
PubTypeId: academicJournal
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  Label: Title
  Group: Ti
  Data: Organocatalytic Enantioselective Conjugate Addition of Isoxazol‐5(4H)‐Ones to Aurone‐Derived Azadienes.
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  Label: Authors
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  Data: <searchLink fieldCode="AR" term="%22Torán%2C+Ricardo%22">Torán, Ricardo</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Torró%2C+Jordi%22">Torró, Jordi</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sanz‐Marco%2C+Amparo%22">Sanz‐Marco, Amparo</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> amparo.sanz-marco@uv.es</i><br /><searchLink fieldCode="AR" term="%22Vila%2C+Carlos%22">Vila, Carlos</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Blay%2C+Gonzalo%22">Blay, Gonzalo</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> gonzalo.blay@uv.es</i>
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  Data: <searchLink fieldCode="JN" term="%22ChemCatChem%22">ChemCatChem</searchLink>. 6/23/2025, Vol. 17 Issue 12, p1-5. 5p.
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  Data: <searchLink fieldCode="DE" term="%22Organocatalysis%22">Organocatalysis</searchLink><br /><searchLink fieldCode="DE" term="%22Conjugate+addition+reactions%22">Conjugate addition reactions</searchLink><br /><searchLink fieldCode="DE" term="%22Stereoselective+reactions%22">Stereoselective reactions</searchLink><br /><searchLink fieldCode="DE" term="%22Azaarenes%22">Azaarenes</searchLink><br /><searchLink fieldCode="DE" term="%22Benzofuran%22">Benzofuran</searchLink><br /><searchLink fieldCode="DE" term="%22Isoxazoles%22">Isoxazoles</searchLink><br /><searchLink fieldCode="DE" term="%22Chiral+drugs%22">Chiral drugs</searchLink><br /><searchLink fieldCode="DE" term="%22Aurones%22">Aurones</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: An efficient enantioselective organocatalytic conjugate addition of isoxazol‐5(4H)‐ones to aurone‐derived azadienes under mild conditions has been developed. This methodology provides access to a wide range of chiral compounds featuring both benzofuran and isoxazole scaffolds in their structures achieving high yields and stereo control. Furthermore, the resulting adducts can be readily transformed into chiral β‐benzofuran‐branched carbonyl compounds in high yields and enantioselectivity in one‐pot reaction through hydrolysis‐decarboxylation of the isoxazole ring. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of ChemCatChem is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1002/cctc.202500033
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      – Code: eng
        Text: English
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        PageCount: 5
        StartPage: 1
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      – SubjectFull: Organocatalysis
        Type: general
      – SubjectFull: Conjugate addition reactions
        Type: general
      – SubjectFull: Stereoselective reactions
        Type: general
      – SubjectFull: Azaarenes
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      – SubjectFull: Benzofuran
        Type: general
      – SubjectFull: Isoxazoles
        Type: general
      – SubjectFull: Chiral drugs
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      – SubjectFull: Aurones
        Type: general
    Titles:
      – TitleFull: Organocatalytic Enantioselective Conjugate Addition of Isoxazol‐5(4H)‐Ones to Aurone‐Derived Azadienes.
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          Name:
            NameFull: Torán, Ricardo
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            NameFull: Torró, Jordi
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            NameFull: Sanz‐Marco, Amparo
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            NameFull: Vila, Carlos
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            – D: 23
              M: 06
              Text: 6/23/2025
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              Y: 2025
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