Eco-friendly synthesis and biomedical potential of zinc oxide nanoparticles using Mentha piperita aqueous extract: comparative analysis with chemically synthesized and commercial nanoparticles.
Saved in:
| Title: | Eco-friendly synthesis and biomedical potential of zinc oxide nanoparticles using Mentha piperita aqueous extract: comparative analysis with chemically synthesized and commercial nanoparticles. |
|---|---|
| Authors: | dos Reis, Roberta A.1,2 (AUTHOR), da Silva, Leonardo L.1 (AUTHOR), Pieretti, Joana C.1 (AUTHOR), Creusot, Benjamin2 (AUTHOR), Lahouari, Sephora1,2 (AUTHOR), Francius, Gregory3 (AUTHOR), da Silva, Ricardo A. G.4 (AUTHOR), Clarot, Igor2 (AUTHOR), Boudier, Ariane2,5 (AUTHOR), Seabra, Amedea B.1 (AUTHOR) amedea.seabra@ufabc.edu.br |
| Source: | Bioprocess & Biosystems Engineering. Aug2025, Vol. 48 Issue 8, p1323-1338. 16p. |
| Subjects: | Biosynthesis, Treatment effectiveness, Stabilizing agents, Cytotoxins, Peppermint |
| Abstract: | Phytosynthesis of zinc oxide nanoparticles (ZnO NPs) using Mentha piperita extract offers a sustainable alternative for biomedical applications. This study investigates the synthesis, characterization, and biological properties of biosynthesized ZnO (ZnO Bio NPs) compared to chemically synthesized (ZnO Chem NPs) and commercial ZnO (ZnO Commercial NPs). We explored how peppermint's phytochemicals influence ZnO NP synthesis and biological interactions. Peppermint-derived phytochemicals act as reducing and stabilizing agents while providing antioxidant and anticarcinogenic benefits, potentially enhancing ZnO Bio NPs' therapeutic effects. Our findings reveal that ZnO Bio NPs exhibit superior stability and bioactivity due to plant-based capping agents. ZnO Bio NPs inhibited 52% of DPPH radicals at 15.63 µg/mL, outperforming ZnO Chem and Commercial NPs. In hemocompatibility studies, ZnO Bio NPs showed minimal hemolysis, both with and without protein corona (albumin and fibrinogen), ensuring safer blood interactions. Cytotoxicity assays demonstrated that ZnO Bio NPs had an IC50 of 49.91 µg/mL in human fibroblasts, threefold less cytotoxic than ZnO Commercial NPs. These results highlight the potential of peppermint-extract-based ZnO NPs for biomedical applications, offering lower cytotoxicity and greater biocompatibility while providing an eco-friendly alternative to conventional synthesis methods. [ABSTRACT FROM AUTHOR] |
| Copyright of Bioprocess & Biosystems Engineering is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
|
Full text is not displayed to guests.
Login for full access.
|
|
| Abstract: | Phytosynthesis of zinc oxide nanoparticles (ZnO NPs) using Mentha piperita extract offers a sustainable alternative for biomedical applications. This study investigates the synthesis, characterization, and biological properties of biosynthesized ZnO (ZnO Bio NPs) compared to chemically synthesized (ZnO Chem NPs) and commercial ZnO (ZnO Commercial NPs). We explored how peppermint's phytochemicals influence ZnO NP synthesis and biological interactions. Peppermint-derived phytochemicals act as reducing and stabilizing agents while providing antioxidant and anticarcinogenic benefits, potentially enhancing ZnO Bio NPs' therapeutic effects. Our findings reveal that ZnO Bio NPs exhibit superior stability and bioactivity due to plant-based capping agents. ZnO Bio NPs inhibited 52% of DPPH radicals at 15.63 µg/mL, outperforming ZnO Chem and Commercial NPs. In hemocompatibility studies, ZnO Bio NPs showed minimal hemolysis, both with and without protein corona (albumin and fibrinogen), ensuring safer blood interactions. Cytotoxicity assays demonstrated that ZnO Bio NPs had an IC50 of 49.91 µg/mL in human fibroblasts, threefold less cytotoxic than ZnO Commercial NPs. These results highlight the potential of peppermint-extract-based ZnO NPs for biomedical applications, offering lower cytotoxicity and greater biocompatibility while providing an eco-friendly alternative to conventional synthesis methods. [ABSTRACT FROM AUTHOR] |
|---|---|
| ISSN: | 16157591 |
| DOI: | 10.1007/s00449-025-03178-6 |
