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Gamma Irradiation-Induced Changes in Microstructure of Cyclic Olefin Copolymer (COC) Revealed by NMR and SAXS Characterization.

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Title: Gamma Irradiation-Induced Changes in Microstructure of Cyclic Olefin Copolymer (COC) Revealed by NMR and SAXS Characterization.
Authors: Zhang, Fan1,2 (AUTHOR), Lei, Heng1,2,3 (AUTHOR), Guo, Feng1,2,3 (AUTHOR), Hu, Jiangtao1,2 (AUTHOR), Liu, Haiming2,3 (AUTHOR), Wang, Qing3 (AUTHOR), Liu, Weihua1,2 (AUTHOR), Xing, Zhe1,2 (AUTHOR), Wu, Guozhong1,2,3 (AUTHOR)
Source: Polymers (20734360). Jul2025, Vol. 17 Issue 13, p1751. 15p.
Subjects: Microstructure, Radiation sterilization, Free radicals, Thermoplastics, Gamma rays, Small-angle X-ray scattering, Particle size distribution, Nuclear magnetic resonance spectroscopy
Abstract: Cyclic Olefin Copolymer (COC) is an amorphous thermoplastic polymer synthesized through the catalytic copolymerization of α-olefin and cyclic olefin. When used in pre-filled syringes and pharmaceutical packaging, COCs require radiation sterilization. The radiation sterilization alters the microstructure of COC, which ultimately affects its performance and biosafety. In this study, to investigate the effects of γ-radiation on COC microstructures, ethylene-norbornene copolymers with various compositions, representative of COC, are studied by nuclear magnetic resonance (NMR) and small angle X-ray scattering (SAXS) techniques. During irradiation, the COC containing 35 mol% norbornene produced free radicals that triggered migration and reaction processes, leading to the formation of entanglements within flexible chain segments. This, in turn, affected nearby ring structures with high steric hindrance, resulting in a 9.2% decrease in internal particle size and an increase in particle spacing. Conversely, when the norbornene content in COC was increased to 57 mol%, the internal particle size increased by 17.9%, while the particle spacing decreased. [ABSTRACT FROM AUTHOR]
Copyright of Polymers (20734360) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Gamma Irradiation-Induced Changes in Microstructure of Cyclic Olefin Copolymer (COC) Revealed by NMR and SAXS Characterization.
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  Data: <searchLink fieldCode="JN" term="%22Polymers+%2820734360%29%22">Polymers (20734360)</searchLink>. Jul2025, Vol. 17 Issue 13, p1751. 15p.
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  Data: <searchLink fieldCode="DE" term="%22Microstructure%22">Microstructure</searchLink><br /><searchLink fieldCode="DE" term="%22Radiation+sterilization%22">Radiation sterilization</searchLink><br /><searchLink fieldCode="DE" term="%22Free+radicals%22">Free radicals</searchLink><br /><searchLink fieldCode="DE" term="%22Thermoplastics%22">Thermoplastics</searchLink><br /><searchLink fieldCode="DE" term="%22Gamma+rays%22">Gamma rays</searchLink><br /><searchLink fieldCode="DE" term="%22Small-angle+X-ray+scattering%22">Small-angle X-ray scattering</searchLink><br /><searchLink fieldCode="DE" term="%22Particle+size+distribution%22">Particle size distribution</searchLink><br /><searchLink fieldCode="DE" term="%22Nuclear+magnetic+resonance+spectroscopy%22">Nuclear magnetic resonance spectroscopy</searchLink>
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  Data: Cyclic Olefin Copolymer (COC) is an amorphous thermoplastic polymer synthesized through the catalytic copolymerization of α-olefin and cyclic olefin. When used in pre-filled syringes and pharmaceutical packaging, COCs require radiation sterilization. The radiation sterilization alters the microstructure of COC, which ultimately affects its performance and biosafety. In this study, to investigate the effects of γ-radiation on COC microstructures, ethylene-norbornene copolymers with various compositions, representative of COC, are studied by nuclear magnetic resonance (NMR) and small angle X-ray scattering (SAXS) techniques. During irradiation, the COC containing 35 mol% norbornene produced free radicals that triggered migration and reaction processes, leading to the formation of entanglements within flexible chain segments. This, in turn, affected nearby ring structures with high steric hindrance, resulting in a 9.2% decrease in internal particle size and an increase in particle spacing. Conversely, when the norbornene content in COC was increased to 57 mol%, the internal particle size increased by 17.9%, while the particle spacing decreased. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Polymers (20734360) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.3390/polym17131751
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        Text: English
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        StartPage: 1751
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      – SubjectFull: Microstructure
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      – SubjectFull: Radiation sterilization
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      – SubjectFull: Free radicals
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      – SubjectFull: Thermoplastics
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      – SubjectFull: Gamma rays
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      – SubjectFull: Small-angle X-ray scattering
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      – SubjectFull: Particle size distribution
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      – SubjectFull: Nuclear magnetic resonance spectroscopy
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            – D: 01
              M: 07
              Text: Jul2025
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