Feasibility and safety assessment of endoscopic laser therapy (ELT) for duodenal mucosal ablation in a porcine model.
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| Title: | Feasibility and safety assessment of endoscopic laser therapy (ELT) for duodenal mucosal ablation in a porcine model. |
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| Authors: | Truong, Van Gia1 (AUTHOR) gvtruong@tecure.com, Jeong, Seok2 (AUTHOR) inos@inha.ac.kr, Lee, Jiho1 (AUTHOR) jlee@tecure.com, Kim, Hyejin1 (AUTHOR) hkim@tecure.com, Ta, Minh Duc3 (AUTHOR) tmduc1997@pukyong.ac.kr, Kang, Hyun Wook1,3,4 (AUTHOR) wkang@pukyong.ac.kr |
| Source: | Lasers in Medical Science. 7/12/2025, Vol. 40 Issue 1, p1-11. 11p. |
| Subjects: | Laser therapy, Semiconductor lasers, Laser ablation, Metabolic disorders, Diabetes |
| Abstract: | The current study aims to assess the feasibility and safety of using endoscopic laser therapy (ELT) to ablate duodenal mucosa in a porcine model. A new endoscopic laser catheter (ELC) was developed to enable circumferential laser ablation of tubular tissue structures for ELT. Both ex vivo and in vivo porcine duodenal tissues were evaluated using a diode laser emitting laser light at 100 J to quantitatively assess thermal distribution and tissue response. In vivo porcine models were used to validate the performance of the ELT in achieving selective mucosal ablation. Assessments were performed at both acute (D0) and chronic (D28) time points after ablation. Ex vivo experimental results showed that the maximum temperature increase occurred at the mucosal surface after laser irradiation, while the minimum temperature increase occurred at the muscle layer. Endoscopic imaging confirmed that the ELC successfully produced uniform circumferential thermal damage around the mucosal surface. In vivo results confirmed selective mucosal ablation without thermal damage to the submucosa or muscular layers in both short- and long-term assessments. Therefore, the proposed ELT may have a therapeutic capacity for remodeling the duodenal mucosa in metabolic disease applications. [ABSTRACT FROM AUTHOR] |
| Copyright of Lasers in Medical Science is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
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| Header | DbId: egs DbLabel: Engineering Source An: 186625641 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Feasibility and safety assessment of endoscopic laser therapy (ELT) for duodenal mucosal ablation in a porcine model. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Truong%2C+Van+Gia%22">Truong, Van Gia</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> gvtruong@tecure.com</i><br /><searchLink fieldCode="AR" term="%22Jeong%2C+Seok%22">Jeong, Seok</searchLink><relatesTo>2</relatesTo> (AUTHOR)<i> inos@inha.ac.kr</i><br /><searchLink fieldCode="AR" term="%22Lee%2C+Jiho%22">Lee, Jiho</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> jlee@tecure.com</i><br /><searchLink fieldCode="AR" term="%22Kim%2C+Hyejin%22">Kim, Hyejin</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> hkim@tecure.com</i><br /><searchLink fieldCode="AR" term="%22Ta%2C+Minh+Duc%22">Ta, Minh Duc</searchLink><relatesTo>3</relatesTo> (AUTHOR)<i> tmduc1997@pukyong.ac.kr</i><br /><searchLink fieldCode="AR" term="%22Kang%2C+Hyun+Wook%22">Kang, Hyun Wook</searchLink><relatesTo>1,3,4</relatesTo> (AUTHOR)<i> wkang@pukyong.ac.kr</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Lasers+in+Medical+Science%22">Lasers in Medical Science</searchLink>. 7/12/2025, Vol. 40 Issue 1, p1-11. 11p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Laser+therapy%22">Laser therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Semiconductor+lasers%22">Semiconductor lasers</searchLink><br /><searchLink fieldCode="DE" term="%22Laser+ablation%22">Laser ablation</searchLink><br /><searchLink fieldCode="DE" term="%22Metabolic+disorders%22">Metabolic disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Diabetes%22">Diabetes</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: The current study aims to assess the feasibility and safety of using endoscopic laser therapy (ELT) to ablate duodenal mucosa in a porcine model. A new endoscopic laser catheter (ELC) was developed to enable circumferential laser ablation of tubular tissue structures for ELT. Both ex vivo and in vivo porcine duodenal tissues were evaluated using a diode laser emitting laser light at 100 J to quantitatively assess thermal distribution and tissue response. In vivo porcine models were used to validate the performance of the ELT in achieving selective mucosal ablation. Assessments were performed at both acute (D0) and chronic (D28) time points after ablation. Ex vivo experimental results showed that the maximum temperature increase occurred at the mucosal surface after laser irradiation, while the minimum temperature increase occurred at the muscle layer. Endoscopic imaging confirmed that the ELC successfully produced uniform circumferential thermal damage around the mucosal surface. In vivo results confirmed selective mucosal ablation without thermal damage to the submucosa or muscular layers in both short- and long-term assessments. Therefore, the proposed ELT may have a therapeutic capacity for remodeling the duodenal mucosa in metabolic disease applications. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Lasers in Medical Science is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s10103-025-04571-z Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 11 StartPage: 1 Subjects: – SubjectFull: Laser therapy Type: general – SubjectFull: Semiconductor lasers Type: general – SubjectFull: Laser ablation Type: general – SubjectFull: Metabolic disorders Type: general – SubjectFull: Diabetes Type: general Titles: – TitleFull: Feasibility and safety assessment of endoscopic laser therapy (ELT) for duodenal mucosal ablation in a porcine model. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Truong, Van Gia – PersonEntity: Name: NameFull: Jeong, Seok – PersonEntity: Name: NameFull: Lee, Jiho – PersonEntity: Name: NameFull: Kim, Hyejin – PersonEntity: Name: NameFull: Ta, Minh Duc – PersonEntity: Name: NameFull: Kang, Hyun Wook IsPartOfRelationships: – BibEntity: Dates: – D: 12 M: 07 Text: 7/12/2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 02688921 Numbering: – Type: volume Value: 40 – Type: issue Value: 1 Titles: – TitleFull: Lasers in Medical Science Type: main |
| ResultId | 1 |
