Bismuth dithiocarbamate complexes as anticancer agents and beyond: a comprehensive review.
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| Title: | Bismuth dithiocarbamate complexes as anticancer agents and beyond: a comprehensive review. |
|---|---|
| Authors: | Verma, Deepika1 (AUTHOR), Gupta, Kiran1 (AUTHOR), Mir, Snober S.2 (AUTHOR), Prakash, Om1 (AUTHOR) ops92002@gmail.com |
| Source: | Dalton Transactions: An International Journal of Inorganic Chemistry. 7/28/2025, Vol. 54 Issue 28, p10830-10846. 17p. |
| Subjects: | Antineoplastic agents, Tumor growth, Anti-infective agents, Drug resistance in cancer cells, Apoptosis, Biochemistry, Chemical synthesis, Bismuth compounds |
| Abstract: | Bismuth dithiocarbamate (Bi-DTC) complexes have emerged as promising candidates in the fight against cancer, attributed to their unique mechanisms of action and low toxicity compared to traditional metal-based therapies. With their sulfur-rich coordination sites, the dithiocarbamate (DTC) ligands facilitate versatile binding and structural diversity, enabling the formation of supramolecular assemblies with potent biological activity. While bismuth itself does not naturally exhibit biological functions, its dithiocarbamate derivatives have demonstrated notable efficacy as anticancer agents and antimicrobial and antiparasitic properties. In vitro and in vivo studies reveal that bismuth dithiocarbamates (Bi-DTC) can effectively induce apoptosis, suppress tumour growth, and overcome chemoresistance, positioning them as innovative therapeutic options. This review examines the synthesis strategies, biological mechanisms, and experimental evidence supporting the anticancer potential of these complexes. It also highlights their antimicrobial and antileishmanial activities, emphasising the role of antimicrobial properties in preventive and supportive therapies during cancer treatment. However, further investigations are essential to delineate their mechanisms of action and optimise their clinical applicability for cancer treatment. [ABSTRACT FROM AUTHOR] |
| Copyright of Dalton Transactions: An International Journal of Inorganic Chemistry is the property of Royal Society of Chemistry and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 186645570 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Bismuth dithiocarbamate complexes as anticancer agents and beyond: a comprehensive review. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Verma%2C+Deepika%22">Verma, Deepika</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gupta%2C+Kiran%22">Gupta, Kiran</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mir%2C+Snober+S%2E%22">Mir, Snober S.</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Prakash%2C+Om%22">Prakash, Om</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> ops92002@gmail.com</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Dalton+Transactions%3A+An+International+Journal+of+Inorganic+Chemistry%22">Dalton Transactions: An International Journal of Inorganic Chemistry</searchLink>. 7/28/2025, Vol. 54 Issue 28, p10830-10846. 17p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Antineoplastic+agents%22">Antineoplastic agents</searchLink><br /><searchLink fieldCode="DE" term="%22Tumor+growth%22">Tumor growth</searchLink><br /><searchLink fieldCode="DE" term="%22Anti-infective+agents%22">Anti-infective agents</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+resistance+in+cancer+cells%22">Drug resistance in cancer cells</searchLink><br /><searchLink fieldCode="DE" term="%22Apoptosis%22">Apoptosis</searchLink><br /><searchLink fieldCode="DE" term="%22Biochemistry%22">Biochemistry</searchLink><br /><searchLink fieldCode="DE" term="%22Chemical+synthesis%22">Chemical synthesis</searchLink><br /><searchLink fieldCode="DE" term="%22Bismuth+compounds%22">Bismuth compounds</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Bismuth dithiocarbamate (Bi-DTC) complexes have emerged as promising candidates in the fight against cancer, attributed to their unique mechanisms of action and low toxicity compared to traditional metal-based therapies. With their sulfur-rich coordination sites, the dithiocarbamate (DTC) ligands facilitate versatile binding and structural diversity, enabling the formation of supramolecular assemblies with potent biological activity. While bismuth itself does not naturally exhibit biological functions, its dithiocarbamate derivatives have demonstrated notable efficacy as anticancer agents and antimicrobial and antiparasitic properties. In vitro and in vivo studies reveal that bismuth dithiocarbamates (Bi-DTC) can effectively induce apoptosis, suppress tumour growth, and overcome chemoresistance, positioning them as innovative therapeutic options. This review examines the synthesis strategies, biological mechanisms, and experimental evidence supporting the anticancer potential of these complexes. It also highlights their antimicrobial and antileishmanial activities, emphasising the role of antimicrobial properties in preventive and supportive therapies during cancer treatment. However, further investigations are essential to delineate their mechanisms of action and optimise their clinical applicability for cancer treatment. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Dalton Transactions: An International Journal of Inorganic Chemistry is the property of Royal Society of Chemistry and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1039/d5dt00656b Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 17 StartPage: 10830 Subjects: – SubjectFull: Antineoplastic agents Type: general – SubjectFull: Tumor growth Type: general – SubjectFull: Anti-infective agents Type: general – SubjectFull: Drug resistance in cancer cells Type: general – SubjectFull: Apoptosis Type: general – SubjectFull: Biochemistry Type: general – SubjectFull: Chemical synthesis Type: general – SubjectFull: Bismuth compounds Type: general Titles: – TitleFull: Bismuth dithiocarbamate complexes as anticancer agents and beyond: a comprehensive review. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Verma, Deepika – PersonEntity: Name: NameFull: Gupta, Kiran – PersonEntity: Name: NameFull: Mir, Snober S. – PersonEntity: Name: NameFull: Prakash, Om IsPartOfRelationships: – BibEntity: Dates: – D: 28 M: 07 Text: 7/28/2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 14779226 Numbering: – Type: volume Value: 54 – Type: issue Value: 28 Titles: – TitleFull: Dalton Transactions: An International Journal of Inorganic Chemistry Type: main |
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