Characterization of a Commercial Ionization Chamber Array With Scanned Proton Beams for Applications in MRI‐Guided Proton Therapy.
Saved in:
| Title: | Characterization of a Commercial Ionization Chamber Array With Scanned Proton Beams for Applications in MRI‐Guided Proton Therapy. |
|---|---|
| Authors: | Gebauer, Benjamin1,2 (AUTHOR), Gantz, Sebastian1,3 (AUTHOR), Kunath, Daniela1,3 (AUTHOR), Hoffmann, Aswin1,2,3 (AUTHOR), Pawelke, Jörg1,2 (AUTHOR), Horst, Felix1,2 (AUTHOR) felix.horst@oncoray.de |
| Source: | Medical Physics. Jul2025, Vol. 52 Issue 7, p1-13. 13p. |
| Subjects: | Proton therapy, Proton beams, Therapeutics, Quality assurance, Magnetic field effects, Ionization chambers, Medical dosimetry |
| Abstract: | Background: The integration of MRI‐guidance and proton therapy is a current research topic. Proton therapy with the patient being placed inside an in‐beam MR scanner would require the presence of its static magnetic (B0$B_0$) field to be taken into account in dose calculation and treatment planning. Therefore, dosimetric tools are needed to characterize dose distributions in presence of the B0$B_0$ field of the MR scanner. Furthermore, patient‐specific quality assurance (QA) and treatment plan verification measurements should also be performed within the magnetic field. Purpose: In this work, the PTW Octavius 1500MR$^{MR}$ ionization chamber array was characterized experimentally and tested for its suitability as a dosimetric tool for beam characterization and QA in MRI‐guided proton therapy. Methods: The dose rate response, response homogeneity and effective measurement depth of the detector were determined in experiments with scanned proton beams delivered by a horizontal beamline at OncoRay, Dresden. A patient‐specific QA test including gamma analysis was performed for a realistic proton patient treatment plan at two different distances from the beam nozzle. In addition, experiments were performed in a 0.32T$0.32 \ \mathrm{T}$ in‐beam MR scanner. These included measurements of square reference scanning patterns at different proton energies as well as measurements of a two‐field patient treatment plan at different water equivalent depths. Results: The dose rate response was found to be linear up to 80Gy/min$80 \ \text{Gy/min}$. The effective measurement depth was determined to be 8.1±0.2mm$8.1 \pm 0.2 \ \mathrm{mm}$. The response homogeneity was found to be suitable for the verification of proton treatment plans. The patient‐specific QA test without magnetic field was satisfactory and also the measurements inside the 0.32T$0.32 \ \mathrm{T}$ in‐beam MR scanner provided reasonable results. Their comparison allowed an assessment of the magnetic field effects on the dose distributions. Conclusions: Concluding from these tests, the Octavius 1500MR$^{MR}$ was found to be suitable for use as a dosimetric tool in MRI‐guided proton therapy. [ABSTRACT FROM AUTHOR] |
| Copyright of Medical Physics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
|
Full text is not displayed to guests.
Login for full access.
|
|
| FullText | Links: – Type: pdflink Text: Availability: 1 |
|---|---|
| Header | DbId: egs DbLabel: Engineering Source An: 186809899 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Characterization of a Commercial Ionization Chamber Array With Scanned Proton Beams for Applications in MRI‐Guided Proton Therapy. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Gebauer%2C+Benjamin%22">Gebauer, Benjamin</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gantz%2C+Sebastian%22">Gantz, Sebastian</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kunath%2C+Daniela%22">Kunath, Daniela</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hoffmann%2C+Aswin%22">Hoffmann, Aswin</searchLink><relatesTo>1,2,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pawelke%2C+Jörg%22">Pawelke, Jörg</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Horst%2C+Felix%22">Horst, Felix</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> felix.horst@oncoray.de</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Medical+Physics%22">Medical Physics</searchLink>. Jul2025, Vol. 52 Issue 7, p1-13. 13p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Proton+therapy%22">Proton therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Proton+beams%22">Proton beams</searchLink><br /><searchLink fieldCode="DE" term="%22Therapeutics%22">Therapeutics</searchLink><br /><searchLink fieldCode="DE" term="%22Quality+assurance%22">Quality assurance</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+field+effects%22">Magnetic field effects</searchLink><br /><searchLink fieldCode="DE" term="%22Ionization+chambers%22">Ionization chambers</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+dosimetry%22">Medical dosimetry</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Background: The integration of MRI‐guidance and proton therapy is a current research topic. Proton therapy with the patient being placed inside an in‐beam MR scanner would require the presence of its static magnetic (B0$B_0$) field to be taken into account in dose calculation and treatment planning. Therefore, dosimetric tools are needed to characterize dose distributions in presence of the B0$B_0$ field of the MR scanner. Furthermore, patient‐specific quality assurance (QA) and treatment plan verification measurements should also be performed within the magnetic field. Purpose: In this work, the PTW Octavius 1500MR$^{MR}$ ionization chamber array was characterized experimentally and tested for its suitability as a dosimetric tool for beam characterization and QA in MRI‐guided proton therapy. Methods: The dose rate response, response homogeneity and effective measurement depth of the detector were determined in experiments with scanned proton beams delivered by a horizontal beamline at OncoRay, Dresden. A patient‐specific QA test including gamma analysis was performed for a realistic proton patient treatment plan at two different distances from the beam nozzle. In addition, experiments were performed in a 0.32T$0.32 \ \mathrm{T}$ in‐beam MR scanner. These included measurements of square reference scanning patterns at different proton energies as well as measurements of a two‐field patient treatment plan at different water equivalent depths. Results: The dose rate response was found to be linear up to 80Gy/min$80 \ \text{Gy/min}$. The effective measurement depth was determined to be 8.1±0.2mm$8.1 \pm 0.2 \ \mathrm{mm}$. The response homogeneity was found to be suitable for the verification of proton treatment plans. The patient‐specific QA test without magnetic field was satisfactory and also the measurements inside the 0.32T$0.32 \ \mathrm{T}$ in‐beam MR scanner provided reasonable results. Their comparison allowed an assessment of the magnetic field effects on the dose distributions. Conclusions: Concluding from these tests, the Octavius 1500MR$^{MR}$ was found to be suitable for use as a dosimetric tool in MRI‐guided proton therapy. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Medical Physics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=186809899 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/mp.17875 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 13 StartPage: 1 Subjects: – SubjectFull: Proton therapy Type: general – SubjectFull: Proton beams Type: general – SubjectFull: Therapeutics Type: general – SubjectFull: Quality assurance Type: general – SubjectFull: Magnetic field effects Type: general – SubjectFull: Ionization chambers Type: general – SubjectFull: Medical dosimetry Type: general Titles: – TitleFull: Characterization of a Commercial Ionization Chamber Array With Scanned Proton Beams for Applications in MRI‐Guided Proton Therapy. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Gebauer, Benjamin – PersonEntity: Name: NameFull: Gantz, Sebastian – PersonEntity: Name: NameFull: Kunath, Daniela – PersonEntity: Name: NameFull: Hoffmann, Aswin – PersonEntity: Name: NameFull: Pawelke, Jörg – PersonEntity: Name: NameFull: Horst, Felix IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 07 Text: Jul2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 00942405 Numbering: – Type: volume Value: 52 – Type: issue Value: 7 Titles: – TitleFull: Medical Physics Type: main |
| ResultId | 1 |
