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Megavoltage photon FLASH for preclinical experiments.

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Title: Megavoltage photon FLASH for preclinical experiments.
Authors: Taylor, Edward R. J. F.1 (AUTHOR), Tullis, Iain D. C.1 (AUTHOR), Vojnovic, Borivoj1 (AUTHOR), Petersson, Kristoffer1,2 (AUTHOR) kristoffer.petersson@oncology.ox.ac.uk
Source: Medical Physics. Jul2025, Vol. 52 Issue 7, p1-10. 10p.
Subjects: Electron accelerators, Radiotherapy, Medical sciences, Radiation absorption, Tungsten, Radiation doses, Photon emission
Abstract: Background: FLASH radiotherapy using megavoltage (MV) photon beams should enable greater therapeutic efficacy, target deep seated tumors, and provide insights into mechanisms within FLASH. Purpose: In this study, we aim to show how to facilitate ultra‐high dose rates (FLASH) with MV photons over a field size of 12–15 mm, using a 6 MeV (nominal) preclinical electron linear accelerator (linac). Our intention is to utilize this setup to deliver FLASH with MV photons in future preclinical experiments. Methods: An electron linear accelerator operating at a pulse repetition frequency of 300 Hz, a tungsten target, and a beam hardening filter were used, in conjunction with beam tuning and source‐to‐surface distance (SSD) reduction. Depth dose curves, beam profiles, and average dose rates were determined using EBT‐XD Gafchromic film, and an Advanced Markus ionization chamber was used to measure the photon charge output. Results: A 0.55 mm thick tungsten target, in combination with a 6 mm thick copper hardening filter were found to produce photon FLASH dose rates, with minimal electron contamination, delivering dose rates > 40 Gy/s over fields of 12–15 mm. Beam flatness and symmetry were comparable in horizontal and vertical planes. Conclusion: Ultra‐high average dose rate beams have been achieved with MV photons for preclinical irradiation fields, enabling future preclinical FLASH radiation experiments. [ABSTRACT FROM AUTHOR]
Copyright of Medical Physics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Megavoltage photon FLASH for preclinical experiments.
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  Data: <searchLink fieldCode="JN" term="%22Medical+Physics%22">Medical Physics</searchLink>. Jul2025, Vol. 52 Issue 7, p1-10. 10p.
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  Data: <searchLink fieldCode="DE" term="%22Electron+accelerators%22">Electron accelerators</searchLink><br /><searchLink fieldCode="DE" term="%22Radiotherapy%22">Radiotherapy</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+sciences%22">Medical sciences</searchLink><br /><searchLink fieldCode="DE" term="%22Radiation+absorption%22">Radiation absorption</searchLink><br /><searchLink fieldCode="DE" term="%22Tungsten%22">Tungsten</searchLink><br /><searchLink fieldCode="DE" term="%22Radiation+doses%22">Radiation doses</searchLink><br /><searchLink fieldCode="DE" term="%22Photon+emission%22">Photon emission</searchLink>
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  Data: Background: FLASH radiotherapy using megavoltage (MV) photon beams should enable greater therapeutic efficacy, target deep seated tumors, and provide insights into mechanisms within FLASH. Purpose: In this study, we aim to show how to facilitate ultra‐high dose rates (FLASH) with MV photons over a field size of 12–15 mm, using a 6 MeV (nominal) preclinical electron linear accelerator (linac). Our intention is to utilize this setup to deliver FLASH with MV photons in future preclinical experiments. Methods: An electron linear accelerator operating at a pulse repetition frequency of 300 Hz, a tungsten target, and a beam hardening filter were used, in conjunction with beam tuning and source‐to‐surface distance (SSD) reduction. Depth dose curves, beam profiles, and average dose rates were determined using EBT‐XD Gafchromic film, and an Advanced Markus ionization chamber was used to measure the photon charge output. Results: A 0.55 mm thick tungsten target, in combination with a 6 mm thick copper hardening filter were found to produce photon FLASH dose rates, with minimal electron contamination, delivering dose rates > 40 Gy/s over fields of 12–15 mm. Beam flatness and symmetry were comparable in horizontal and vertical planes. Conclusion: Ultra‐high average dose rate beams have been achieved with MV photons for preclinical irradiation fields, enabling future preclinical FLASH radiation experiments. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Medical Physics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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              M: 07
              Text: Jul2025
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