Assessing repeatability and confounding factors of magnetic resonance fingerprinting (MRF) for quantitative liver imaging.
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| Title: | Assessing repeatability and confounding factors of magnetic resonance fingerprinting (MRF) for quantitative liver imaging. |
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| Authors: | Lu, Lan1 (AUTHOR), Stephans, Kevin1 (AUTHOR), Qiu, Zhilang2 (AUTHOR), Tirumani, Sree2,3 (AUTHOR), Chen, Yong2,3 (AUTHOR) yxc235@case.edu |
| Source: | Medical Physics. Jul2025, Vol. 52 Issue 7, p1-12. 12p. |
| Subjects: | Magnetic resonance imaging, Reproducible research, Liver disease diagnosis, Statistical reliability, Sensitivity analysis, Quantitative research, Treatment effectiveness |
| Abstract: | Background: Advanced radiation therapy techniques are increasingly used to treat liver cancers. However, the lack of robust imaging approaches for reliable assessment of early‐phase treatment response limits full potential of these therapeutic methods. Purpose: To evaluate the performance of a new quantitative MR imaging technique, named magnetic resonance fingerprinting (MRF), in terms of repeatability, reproducibility, and motion sensitivity for quantitative T1 and T2 assessment in hepatic tissues. Methods: A rapid 2D liver MRF technique based on a steady‐state free precession sequence was adapted and performed on 3T MR scanners. Quantitative T1 and T2 relaxation time maps with a spatial resolution of 1.6 mm and slice thickness of 5 mm were acquired simultaneously in one breath‐hold of 15 s per imaging slice. The accuracy of the liver MRF method was first validated using the standardized water phantom. The repeatability and reproducibility of the liver MRF were further evaluated on five healthy volunteers. Each volunteer was scanned once per week for three consecutive weeks. The effects of dietary status and respiratory motion were further evaluated on three subjects. Finally, a pilot study was performed on one patient with multiple metastatic lesions. Results: Phantom experiments show the liver MRF method achieved an accurate assessment for T1 up to 2000 ms and T2 up to 300 ms. High‐quality quantitative T1 and T2 maps were successfully obtained from all five subjects. Bland‐Altman plots show that both T1 and T2 obtained from MRF are highly repeatable, with a coefficient of repeatability of 86 ms for T1 and 9 ms for T2. The quantitative measurements are also highly reproducible with a coefficient of variation of 1.5% ± 0.2% for T1 (range, 1.3%–1.7%) and 4.1% ± 1.3% for T2 (range, 2.9%–5.5%). The MRF‐derived T1 and T2 measurements are independent of dietary status. However, clear motion artifacts and vessel blurring were noted in motion‐contaminated scan scenarios, which had instructions for 10 s initial breath‐holding followed by 5 s shallow breathing. Finally, higher T1 and T2 values were observed in the metastatic lesions as compared to the values obtained in normal liver parenchyma. Conclusion: This pilot study demonstrates that 2D liver MRF can provide high‐quality, repeatable, and reproducible T1 and T2 mapping for hepatic tissues. These findings suggest potential applications in tissue/lesion characterization and longitudinal treatment response monitoring in the liver. [ABSTRACT FROM AUTHOR] |
| Copyright of Medical Physics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
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| Header | DbId: egs DbLabel: Engineering Source An: 186809949 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Assessing repeatability and confounding factors of magnetic resonance fingerprinting (MRF) for quantitative liver imaging. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Lu%2C+Lan%22">Lu, Lan</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Stephans%2C+Kevin%22">Stephans, Kevin</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Qiu%2C+Zhilang%22">Qiu, Zhilang</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tirumani%2C+Sree%22">Tirumani, Sree</searchLink><relatesTo>2,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chen%2C+Yong%22">Chen, Yong</searchLink><relatesTo>2,3</relatesTo> (AUTHOR)<i> yxc235@case.edu</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Medical+Physics%22">Medical Physics</searchLink>. Jul2025, Vol. 52 Issue 7, p1-12. 12p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Reproducible+research%22">Reproducible research</searchLink><br /><searchLink fieldCode="DE" term="%22Liver+disease+diagnosis%22">Liver disease diagnosis</searchLink><br /><searchLink fieldCode="DE" term="%22Statistical+reliability%22">Statistical reliability</searchLink><br /><searchLink fieldCode="DE" term="%22Sensitivity+analysis%22">Sensitivity analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Quantitative+research%22">Quantitative research</searchLink><br /><searchLink fieldCode="DE" term="%22Treatment+effectiveness%22">Treatment effectiveness</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Background: Advanced radiation therapy techniques are increasingly used to treat liver cancers. However, the lack of robust imaging approaches for reliable assessment of early‐phase treatment response limits full potential of these therapeutic methods. Purpose: To evaluate the performance of a new quantitative MR imaging technique, named magnetic resonance fingerprinting (MRF), in terms of repeatability, reproducibility, and motion sensitivity for quantitative T1 and T2 assessment in hepatic tissues. Methods: A rapid 2D liver MRF technique based on a steady‐state free precession sequence was adapted and performed on 3T MR scanners. Quantitative T1 and T2 relaxation time maps with a spatial resolution of 1.6 mm and slice thickness of 5 mm were acquired simultaneously in one breath‐hold of 15 s per imaging slice. The accuracy of the liver MRF method was first validated using the standardized water phantom. The repeatability and reproducibility of the liver MRF were further evaluated on five healthy volunteers. Each volunteer was scanned once per week for three consecutive weeks. The effects of dietary status and respiratory motion were further evaluated on three subjects. Finally, a pilot study was performed on one patient with multiple metastatic lesions. Results: Phantom experiments show the liver MRF method achieved an accurate assessment for T1 up to 2000 ms and T2 up to 300 ms. High‐quality quantitative T1 and T2 maps were successfully obtained from all five subjects. Bland‐Altman plots show that both T1 and T2 obtained from MRF are highly repeatable, with a coefficient of repeatability of 86 ms for T1 and 9 ms for T2. The quantitative measurements are also highly reproducible with a coefficient of variation of 1.5% ± 0.2% for T1 (range, 1.3%–1.7%) and 4.1% ± 1.3% for T2 (range, 2.9%–5.5%). The MRF‐derived T1 and T2 measurements are independent of dietary status. However, clear motion artifacts and vessel blurring were noted in motion‐contaminated scan scenarios, which had instructions for 10 s initial breath‐holding followed by 5 s shallow breathing. Finally, higher T1 and T2 values were observed in the metastatic lesions as compared to the values obtained in normal liver parenchyma. Conclusion: This pilot study demonstrates that 2D liver MRF can provide high‐quality, repeatable, and reproducible T1 and T2 mapping for hepatic tissues. These findings suggest potential applications in tissue/lesion characterization and longitudinal treatment response monitoring in the liver. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Medical Physics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/mp.17932 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 12 StartPage: 1 Subjects: – SubjectFull: Magnetic resonance imaging Type: general – SubjectFull: Reproducible research Type: general – SubjectFull: Liver disease diagnosis Type: general – SubjectFull: Statistical reliability Type: general – SubjectFull: Sensitivity analysis Type: general – SubjectFull: Quantitative research Type: general – SubjectFull: Treatment effectiveness Type: general Titles: – TitleFull: Assessing repeatability and confounding factors of magnetic resonance fingerprinting (MRF) for quantitative liver imaging. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Lu, Lan – PersonEntity: Name: NameFull: Stephans, Kevin – PersonEntity: Name: NameFull: Qiu, Zhilang – PersonEntity: Name: NameFull: Tirumani, Sree – PersonEntity: Name: NameFull: Chen, Yong IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 07 Text: Jul2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 00942405 Numbering: – Type: volume Value: 52 – Type: issue Value: 7 Titles: – TitleFull: Medical Physics Type: main |
| ResultId | 1 |
