View in EDS

NIR laser activating and camptothecin boosting oxidative stress cascade amplification for high-efficiency synergistic cancer therapy with immune responses activation.

Saved in:
Bibliographic Details
Title: NIR laser activating and camptothecin boosting oxidative stress cascade amplification for high-efficiency synergistic cancer therapy with immune responses activation.
Authors: Tan, Qiuxia1 (AUTHOR), Pang, E1 (AUTHOR), Chen, Yongzhi1,2 (AUTHOR), Tang, Yuanyu1 (AUTHOR), Zhu, Pan1 (AUTHOR), Zhao, Shaojing1 (AUTHOR) 31180030@csu.edu.cn, Jin, Shiguang1,3 (AUTHOR) jinshiguang20230419@njmu.edu.cn, Lan, Minhuan1 (AUTHOR) minhuanlan@csu.edu.cn
Source: Chemical Engineering Journal. Sep2025, Vol. 519, pN.PAG-N.PAG. 1p.
Subjects: Nicotinamide adenine dinucleotide phosphate, Photothermal effect, Oxidative stress, Reactive oxygen species, Hydroxyl group, Camptothecin
Abstract: Oxidative stress (OS) has been extensively investigated for cancer treatment. However, existing reactive oxygen species (ROS)-based therapies are often compromised by the tumor antioxidant system and lack efficient strategies to amplify OS. Here, we developed a cascade-amplified nanoplatform (COP-Mn NPs) by assembling with COTIC-4F, camptothecin and manganese carbonyl (Mn 2 (CO) 10) that integrates photodynamic therapy (PDT), photothermal therapy (PTT), chemotherapy, chemodynamic therapy (CDT), and gas therapy to synergistically disrupt the antioxidant defense and trigger explosive ROS generation. In COP-Mn NPs, COTIC-4F generates ROS and heat for PDT and PTT, respectively. Camptothecin not only directly induces tumor cell death via chemotherapy but also enhances intratumoural hydrogen peroxide (H 2 O 2) concentration through nicotinamide adenine dinucleotide phosphate oxidase activation. The photothermal effect further drives H₂O₂ and Mn₂(CO)₁₀ to produce hydroxyl radicals and CO, enabling CDT and gas therapy. This multi-mechanistic cascade induces a sustained ROS storm, overcomes tumor antioxidant program, and significantly enhances immunogenic cell death compared to single-modal ROS therapies. Moreover, NIR-II fluorescence imaging guides precise tumor positioning. Our work provides a paradigm for designing OS-amplified nanoplatforms with improved efficacy against tumors. NIR laser activating and camptothecin boosting oxidative stress cascade amplification for high-efficiency synergistic cancer therapy with immune responses activation. [Display omitted] • Multimodal cascade therapy amplifies oxidative stress via ROS storm. • Self-supplied H₂O₂ by CPT sustains cascaded reactions for enhanced CDT and gas therapy. • NIR-II imaging-guided PDT/PTT synergizes with chemo−/chemodynamic/gas therapy. • ROS burst induces immunogenic cell death, boosting antitumor immunity. • Biocompatible COP-Mn NPs exhibit high efficacy with minimal systemic toxicity. [ABSTRACT FROM AUTHOR]
Copyright of Chemical Engineering Journal is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
Description
Abstract:Oxidative stress (OS) has been extensively investigated for cancer treatment. However, existing reactive oxygen species (ROS)-based therapies are often compromised by the tumor antioxidant system and lack efficient strategies to amplify OS. Here, we developed a cascade-amplified nanoplatform (COP-Mn NPs) by assembling with COTIC-4F, camptothecin and manganese carbonyl (Mn 2 (CO) 10) that integrates photodynamic therapy (PDT), photothermal therapy (PTT), chemotherapy, chemodynamic therapy (CDT), and gas therapy to synergistically disrupt the antioxidant defense and trigger explosive ROS generation. In COP-Mn NPs, COTIC-4F generates ROS and heat for PDT and PTT, respectively. Camptothecin not only directly induces tumor cell death via chemotherapy but also enhances intratumoural hydrogen peroxide (H 2 O 2) concentration through nicotinamide adenine dinucleotide phosphate oxidase activation. The photothermal effect further drives H₂O₂ and Mn₂(CO)₁₀ to produce hydroxyl radicals and CO, enabling CDT and gas therapy. This multi-mechanistic cascade induces a sustained ROS storm, overcomes tumor antioxidant program, and significantly enhances immunogenic cell death compared to single-modal ROS therapies. Moreover, NIR-II fluorescence imaging guides precise tumor positioning. Our work provides a paradigm for designing OS-amplified nanoplatforms with improved efficacy against tumors. NIR laser activating and camptothecin boosting oxidative stress cascade amplification for high-efficiency synergistic cancer therapy with immune responses activation. [Display omitted] • Multimodal cascade therapy amplifies oxidative stress via ROS storm. • Self-supplied H₂O₂ by CPT sustains cascaded reactions for enhanced CDT and gas therapy. • NIR-II imaging-guided PDT/PTT synergizes with chemo−/chemodynamic/gas therapy. • ROS burst induces immunogenic cell death, boosting antitumor immunity. • Biocompatible COP-Mn NPs exhibit high efficacy with minimal systemic toxicity. [ABSTRACT FROM AUTHOR]
ISSN:13858947
DOI:10.1016/j.cej.2025.165523