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Surface Molecularly Imprinted Polymer–Needle Trap Device for the Biomonitoring of Two Neurotoxic Compounds in Exhaled Air.

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Title: Surface Molecularly Imprinted Polymer–Needle Trap Device for the Biomonitoring of Two Neurotoxic Compounds in Exhaled Air.
Authors: Zendehdel, Rezvan1 (AUTHOR), Jalili, Vahid1 (AUTHOR), Ebrahimzadeh, Homeira2 (AUTHOR), Shekarloo, Masoomeh Vahabi3 (AUTHOR) vahabi-m@ajums.ac.ir
Source: Journal of Analytical Chemistry. Jul2025, Vol. 80 Issue 7, p1152-1162. 11p.
Subjects: Hexane, Methyl ethyl ketone, Respiration, Imprinted polymers, Neurotoxic agents, Biological monitoring, Scientific method
Abstract: This study aimed to develop a needle trap device (NTD) packed with a new molecularly imprinted polymer (MIP) extraction medium for the selective detection of n-hexane and methyl ethyl ketone (MEK) from exhaled air samples. Characterizations of the synthesized MIP were investigated by Fourier transform infrared spectroscopy, field emission scanning electron microscopy, thermogravimetric analysis, and Brunauer–Emmett–Teller. Also, the optimization of desorption parameters such as time and temperature was performed by a central composite design-response surface methodology. First, extraction and determination of MEK and n-hexane were conducted by the proposed method on the laboratory scale and then used in a field study for shoe factory workers. Based on the results, the optimal desorption temperature and time were obtained at 190°C over 120 s, respectively. The analytical performance of NTD-MIP was confirmed by a recovery level > 98.7% and precision by relative standard deviations between 2.06 and 8.05%. Furthermore, the limit of detection and the limit of quantitation of the NTD-MIP method were determined in the range of 0.024–0.020 and 0.080–0.069 ppm, respectively. It is worth mentioning that NTD-MIP showed a high analytical performance compared to the standard the National Institute for Occupational Safety and Health (NIOSH) method in all evaluated validation parameters. These results elucidated that the proposed NTD-MIP method can be employed as an eco-friendly, efficient, and selective procedure for monitoring n-hexane and MEK in exhaled air. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Analytical Chemistry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Label: Title
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  Data: Surface Molecularly Imprinted Polymer–Needle Trap Device for the Biomonitoring of Two Neurotoxic Compounds in Exhaled Air.
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  Data: <searchLink fieldCode="AR" term="%22Zendehdel%2C+Rezvan%22">Zendehdel, Rezvan</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jalili%2C+Vahid%22">Jalili, Vahid</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ebrahimzadeh%2C+Homeira%22">Ebrahimzadeh, Homeira</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Shekarloo%2C+Masoomeh+Vahabi%22">Shekarloo, Masoomeh Vahabi</searchLink><relatesTo>3</relatesTo> (AUTHOR)<i> vahabi-m@ajums.ac.ir</i>
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Analytical+Chemistry%22">Journal of Analytical Chemistry</searchLink>. Jul2025, Vol. 80 Issue 7, p1152-1162. 11p.
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  Data: <searchLink fieldCode="DE" term="%22Hexane%22">Hexane</searchLink><br /><searchLink fieldCode="DE" term="%22Methyl+ethyl+ketone%22">Methyl ethyl ketone</searchLink><br /><searchLink fieldCode="DE" term="%22Respiration%22">Respiration</searchLink><br /><searchLink fieldCode="DE" term="%22Imprinted+polymers%22">Imprinted polymers</searchLink><br /><searchLink fieldCode="DE" term="%22Neurotoxic+agents%22">Neurotoxic agents</searchLink><br /><searchLink fieldCode="DE" term="%22Biological+monitoring%22">Biological monitoring</searchLink><br /><searchLink fieldCode="DE" term="%22Scientific+method%22">Scientific method</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: This study aimed to develop a needle trap device (NTD) packed with a new molecularly imprinted polymer (MIP) extraction medium for the selective detection of n-hexane and methyl ethyl ketone (MEK) from exhaled air samples. Characterizations of the synthesized MIP were investigated by Fourier transform infrared spectroscopy, field emission scanning electron microscopy, thermogravimetric analysis, and Brunauer–Emmett–Teller. Also, the optimization of desorption parameters such as time and temperature was performed by a central composite design-response surface methodology. First, extraction and determination of MEK and n-hexane were conducted by the proposed method on the laboratory scale and then used in a field study for shoe factory workers. Based on the results, the optimal desorption temperature and time were obtained at 190°C over 120 s, respectively. The analytical performance of NTD-MIP was confirmed by a recovery level > 98.7% and precision by relative standard deviations between 2.06 and 8.05%. Furthermore, the limit of detection and the limit of quantitation of the NTD-MIP method were determined in the range of 0.024–0.020 and 0.080–0.069 ppm, respectively. It is worth mentioning that NTD-MIP showed a high analytical performance compared to the standard the National Institute for Occupational Safety and Health (NIOSH) method in all evaluated validation parameters. These results elucidated that the proposed NTD-MIP method can be employed as an eco-friendly, efficient, and selective procedure for monitoring n-hexane and MEK in exhaled air. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Analytical Chemistry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1134/S1061934824603414
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      – Code: eng
        Text: English
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        PageCount: 11
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    Subjects:
      – SubjectFull: Hexane
        Type: general
      – SubjectFull: Methyl ethyl ketone
        Type: general
      – SubjectFull: Respiration
        Type: general
      – SubjectFull: Imprinted polymers
        Type: general
      – SubjectFull: Neurotoxic agents
        Type: general
      – SubjectFull: Biological monitoring
        Type: general
      – SubjectFull: Scientific method
        Type: general
    Titles:
      – TitleFull: Surface Molecularly Imprinted Polymer–Needle Trap Device for the Biomonitoring of Two Neurotoxic Compounds in Exhaled Air.
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            NameFull: Zendehdel, Rezvan
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            NameFull: Jalili, Vahid
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            NameFull: Ebrahimzadeh, Homeira
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            NameFull: Shekarloo, Masoomeh Vahabi
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            – D: 01
              M: 07
              Text: Jul2025
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              Y: 2025
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