Enhanced Mechanical and Biological Properties of 3D Gelatin/Poly(Vinyl Alcohol) Hydrogels Reinforced With TiO2 Nanoparticles for Wound Dressing Applications.
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| Title: | Enhanced Mechanical and Biological Properties of 3D Gelatin/Poly(Vinyl Alcohol) Hydrogels Reinforced With TiO |
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| Authors: | Naeini, Adnan Alizadeh1 (AUTHOR), Hadianfard, Mohammad Jafar1 (AUTHOR) hadianfa@shirazu.ac.ir, Hashemi, Seyedeh‐Sara2,3 (AUTHOR) sara_hashemi23@yahoo.com, Kian, Mehdi3,4 (AUTHOR) |
| Source: | Polymers for Advanced Technologies. Jul2025, Vol. 36 Issue 7, p1-16. 16p. |
| Subjects: | Titanium dioxide, Wound healing, Surgical dressings, Vinyl polymers, Mechanical behavior of materials, Gelatin, Hydrogels, Biocompatibility |
| Abstract: | Three‐dimensional porous hydrogel films made of gelatin (Gel) and poly(vinyl alcohol) (PVA) were developed using the freeze–thaw method, incorporating varying concentrations (1%, 3%, and 5%) of titanium dioxide nanoparticles (TiO2‐NPs) for potential wound dressing applications. The characterization of these films involved multiple techniques, including scanning electron microscopy and Fourier transform infrared spectroscopy. Key properties such as swelling degree, degradation behavior, water vapor transmission rate (WVTR), water contact angle (WCA), mechanical strength, biocompatibility, and in vivo wound healing efficacy were thoroughly analyzed. The observed differences were statistically significant (p < 0.05), confirming the reliability of the improvements. Among the formulations, the Gel/PVA composite with 3% TiO2‐NPs exhibited superior mechanical properties, including a tensile strength of 15.56 MPa, elongation at break of 29.16%, and Young's modulus of 288.7 MPa (p < 0.05). This formulation also demonstrated an optimal 3D network structure, high WVTR (2546.67 g/m2/day), moderate WCA (67.63°), and a degradation rate of 29.4%. The Gel/PVA/3% TiO2‐NPs film showed enhanced compatibility with fibroblast cells and improved wound healing efficacy in vivo compared to the Gel/PVA film alone (p < 0.05). The observed biological performance is attributed to the ability of TiO2‐NPs to enhance cell adhesion and proliferation via improved surface interactions and moderate reactive oxygen species modulation. While previous studies have incorporated TiO2‐NPs into hydrogels, few have systematically compared their physicochemical and biological effects across multiple concentrations in a single formulation. Our findings demonstrate that the 3% TiO2‐NPs composite uniquely balances mechanical strength, degradation rate, and biological efficacy. This study highlights the potential of TiO2‐reinforced Gel/PVA hydrogels to address key limitations of conventional wound dressings, offering a well‐balanced solution in terms of structural integrity, controlled degradation, and enhanced healing response. [ABSTRACT FROM AUTHOR] |
| Copyright of Polymers for Advanced Technologies is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
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| Header | DbId: egs DbLabel: Engineering Source An: 186996900 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Enhanced Mechanical and Biological Properties of 3D Gelatin/Poly(Vinyl Alcohol) Hydrogels Reinforced With TiO<subscript>2</subscript> Nanoparticles for Wound Dressing Applications. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Naeini%2C+Adnan+Alizadeh%22">Naeini, Adnan Alizadeh</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hadianfard%2C+Mohammad+Jafar%22">Hadianfard, Mohammad Jafar</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> hadianfa@shirazu.ac.ir</i><br /><searchLink fieldCode="AR" term="%22Hashemi%2C+Seyedeh‐Sara%22">Hashemi, Seyedeh‐Sara</searchLink><relatesTo>2,3</relatesTo> (AUTHOR)<i> sara_hashemi23@yahoo.com</i><br /><searchLink fieldCode="AR" term="%22Kian%2C+Mehdi%22">Kian, Mehdi</searchLink><relatesTo>3,4</relatesTo> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Polymers+for+Advanced+Technologies%22">Polymers for Advanced Technologies</searchLink>. Jul2025, Vol. 36 Issue 7, p1-16. 16p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Titanium+dioxide%22">Titanium dioxide</searchLink><br /><searchLink fieldCode="DE" term="%22Wound+healing%22">Wound healing</searchLink><br /><searchLink fieldCode="DE" term="%22Surgical+dressings%22">Surgical dressings</searchLink><br /><searchLink fieldCode="DE" term="%22Vinyl+polymers%22">Vinyl polymers</searchLink><br /><searchLink fieldCode="DE" term="%22Mechanical+behavior+of+materials%22">Mechanical behavior of materials</searchLink><br /><searchLink fieldCode="DE" term="%22Gelatin%22">Gelatin</searchLink><br /><searchLink fieldCode="DE" term="%22Hydrogels%22">Hydrogels</searchLink><br /><searchLink fieldCode="DE" term="%22Biocompatibility%22">Biocompatibility</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Three‐dimensional porous hydrogel films made of gelatin (Gel) and poly(vinyl alcohol) (PVA) were developed using the freeze–thaw method, incorporating varying concentrations (1%, 3%, and 5%) of titanium dioxide nanoparticles (TiO2‐NPs) for potential wound dressing applications. The characterization of these films involved multiple techniques, including scanning electron microscopy and Fourier transform infrared spectroscopy. Key properties such as swelling degree, degradation behavior, water vapor transmission rate (WVTR), water contact angle (WCA), mechanical strength, biocompatibility, and in vivo wound healing efficacy were thoroughly analyzed. The observed differences were statistically significant (p < 0.05), confirming the reliability of the improvements. Among the formulations, the Gel/PVA composite with 3% TiO2‐NPs exhibited superior mechanical properties, including a tensile strength of 15.56 MPa, elongation at break of 29.16%, and Young's modulus of 288.7 MPa (p < 0.05). This formulation also demonstrated an optimal 3D network structure, high WVTR (2546.67 g/m2/day), moderate WCA (67.63°), and a degradation rate of 29.4%. The Gel/PVA/3% TiO2‐NPs film showed enhanced compatibility with fibroblast cells and improved wound healing efficacy in vivo compared to the Gel/PVA film alone (p < 0.05). The observed biological performance is attributed to the ability of TiO2‐NPs to enhance cell adhesion and proliferation via improved surface interactions and moderate reactive oxygen species modulation. While previous studies have incorporated TiO2‐NPs into hydrogels, few have systematically compared their physicochemical and biological effects across multiple concentrations in a single formulation. Our findings demonstrate that the 3% TiO2‐NPs composite uniquely balances mechanical strength, degradation rate, and biological efficacy. This study highlights the potential of TiO2‐reinforced Gel/PVA hydrogels to address key limitations of conventional wound dressings, offering a well‐balanced solution in terms of structural integrity, controlled degradation, and enhanced healing response. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Polymers for Advanced Technologies is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/pat.70244 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 16 StartPage: 1 Subjects: – SubjectFull: Titanium dioxide Type: general – SubjectFull: Wound healing Type: general – SubjectFull: Surgical dressings Type: general – SubjectFull: Vinyl polymers Type: general – SubjectFull: Mechanical behavior of materials Type: general – SubjectFull: Gelatin Type: general – SubjectFull: Hydrogels Type: general – SubjectFull: Biocompatibility Type: general Titles: – TitleFull: Enhanced Mechanical and Biological Properties of 3D Gelatin/Poly(Vinyl Alcohol) Hydrogels Reinforced With TiO2 Nanoparticles for Wound Dressing Applications. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Naeini, Adnan Alizadeh – PersonEntity: Name: NameFull: Hadianfard, Mohammad Jafar – PersonEntity: Name: NameFull: Hashemi, Seyedeh‐Sara – PersonEntity: Name: NameFull: Kian, Mehdi IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 07 Text: Jul2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 10427147 Numbering: – Type: volume Value: 36 – Type: issue Value: 7 Titles: – TitleFull: Polymers for Advanced Technologies Type: main |
| ResultId | 1 |
