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Association of occupational testicular radiation exposure with offspring sex ratio.

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Title: Association of occupational testicular radiation exposure with offspring sex ratio.
Authors: Hijikata, Yasukazu1,2,3, Kamitani, Tsukasa4, Yamamoto, Yosuke1, Itaya, Takahiro1, Matsuoka, Yoshinori1,5, Morota, Koichi6, Funao, Haruki7, Miyagi, Masayuki8, Morimoto, Tadatsugu9, Kanno, Haruo10, Suzuki, Akinobu11, Kotani, Yoshihisa12, Ishii, Ken13,14
Source: Annals of Work Exposures & Health. Jun2025, Vol. 69 Issue 5, p544-552. 9p.
Subjects: Behavioral assessment, Radiation protection, Dose-response relationship (Radiation), Risk assessment, Secondary analysis, Spermatozoa, Radiation, Questionnaires, Sex ratio, Surgeons, Minimally invasive procedures, Descriptive statistics, Surveys, Occupational exposure, Testis, Environmental exposure, Fathers, Gestational age, Protective clothing, Chromosomes, Health promotion, Posture, Confidence intervals, Data analysis software, Psychosocial factors, Spine diseases, Time
Geographic Terms: Japan
Abstract: Objectives The association between paternal occupational radiation exposure and the sex ratio of offspring remains controversial. Therefore, we aimed to explore testicular radiation exposure in spine surgeons and its association with their offspring's sex ratio. Methods The Minimally Invasive Spine Treatment Society in Japan administered a survey in October 2020. Male surgeons were divided into high- and low-radiation exposure groups according to the type of lead protectors used during the time frame surrounding the child's conception. Apron-type lead protectors were associated with high exposure, while no radiation or using a coat-type protector was considered low exposure. Risk ratios were calculated via generalized estimating equations with a log link binomial distribution. A secondary analysis was conducted wherein the high-exposure group was further divided into 2 categories based on whether they were in a posture that facilitated exposure during the procedures. Results A total of 209 male surgeons participated, providing responses regarding 436 children, of which 308 and 128 were associated with high and low radiation exposure, respectively. There were more female children in the high-exposure group (53% versus 39%). The adjusted risk ratio for the child being female with high exposure was 1.35 (95% CI: 1.04 to 1.73). A dose–response relationship was observed: the adjusted risk ratios for high exposure with and without an exposure-prone posture were 1.36 (1.04 to 1.78) and 1.30 (0.96 to 1.78), respectively. Conclusions High radiation exposure to the testes is associated with a lower male-sex ratio in offspring. Medical professionals using radiation should ensure proper radiation protection. [ABSTRACT FROM AUTHOR]
Copyright of Annals of Work Exposures & Health is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Association of occupational testicular radiation exposure with offspring sex ratio.
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  Data: <searchLink fieldCode="AR" term="%22Hijikata%2C+Yasukazu%22">Hijikata, Yasukazu</searchLink><relatesTo>1,2,3</relatesTo><br /><searchLink fieldCode="AR" term="%22Kamitani%2C+Tsukasa%22">Kamitani, Tsukasa</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Yamamoto%2C+Yosuke%22">Yamamoto, Yosuke</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Itaya%2C+Takahiro%22">Itaya, Takahiro</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Matsuoka%2C+Yoshinori%22">Matsuoka, Yoshinori</searchLink><relatesTo>1,5</relatesTo><br /><searchLink fieldCode="AR" term="%22Morota%2C+Koichi%22">Morota, Koichi</searchLink><relatesTo>6</relatesTo><br /><searchLink fieldCode="AR" term="%22Funao%2C+Haruki%22">Funao, Haruki</searchLink><relatesTo>7</relatesTo><br /><searchLink fieldCode="AR" term="%22Miyagi%2C+Masayuki%22">Miyagi, Masayuki</searchLink><relatesTo>8</relatesTo><br /><searchLink fieldCode="AR" term="%22Morimoto%2C+Tadatsugu%22">Morimoto, Tadatsugu</searchLink><relatesTo>9</relatesTo><br /><searchLink fieldCode="AR" term="%22Kanno%2C+Haruo%22">Kanno, Haruo</searchLink><relatesTo>10</relatesTo><br /><searchLink fieldCode="AR" term="%22Suzuki%2C+Akinobu%22">Suzuki, Akinobu</searchLink><relatesTo>11</relatesTo><br /><searchLink fieldCode="AR" term="%22Kotani%2C+Yoshihisa%22">Kotani, Yoshihisa</searchLink><relatesTo>12</relatesTo><br /><searchLink fieldCode="AR" term="%22Ishii%2C+Ken%22">Ishii, Ken</searchLink><relatesTo>13,14</relatesTo>
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  Data: <searchLink fieldCode="JN" term="%22Annals+of+Work+Exposures+%26+Health%22">Annals of Work Exposures & Health</searchLink>. Jun2025, Vol. 69 Issue 5, p544-552. 9p.
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  Data: <searchLink fieldCode="DE" term="%22Behavioral+assessment%22">Behavioral assessment</searchLink><br /><searchLink fieldCode="DE" term="%22Radiation+protection%22">Radiation protection</searchLink><br /><searchLink fieldCode="DE" term="%22Dose-response+relationship+%28Radiation%29%22">Dose-response relationship (Radiation)</searchLink><br /><searchLink fieldCode="DE" term="%22Risk+assessment%22">Risk assessment</searchLink><br /><searchLink fieldCode="DE" term="%22Secondary+analysis%22">Secondary analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Spermatozoa%22">Spermatozoa</searchLink><br /><searchLink fieldCode="DE" term="%22Radiation%22">Radiation</searchLink><br /><searchLink fieldCode="DE" term="%22Questionnaires%22">Questionnaires</searchLink><br /><searchLink fieldCode="DE" term="%22Sex+ratio%22">Sex ratio</searchLink><br /><searchLink fieldCode="DE" term="%22Surgeons%22">Surgeons</searchLink><br /><searchLink fieldCode="DE" term="%22Minimally+invasive+procedures%22">Minimally invasive procedures</searchLink><br /><searchLink fieldCode="DE" term="%22Descriptive+statistics%22">Descriptive statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Surveys%22">Surveys</searchLink><br /><searchLink fieldCode="DE" term="%22Occupational+exposure%22">Occupational exposure</searchLink><br /><searchLink fieldCode="DE" term="%22Testis%22">Testis</searchLink><br /><searchLink fieldCode="DE" term="%22Environmental+exposure%22">Environmental exposure</searchLink><br /><searchLink fieldCode="DE" term="%22Fathers%22">Fathers</searchLink><br /><searchLink fieldCode="DE" term="%22Gestational+age%22">Gestational age</searchLink><br /><searchLink fieldCode="DE" term="%22Protective+clothing%22">Protective clothing</searchLink><br /><searchLink fieldCode="DE" term="%22Chromosomes%22">Chromosomes</searchLink><br /><searchLink fieldCode="DE" term="%22Health+promotion%22">Health promotion</searchLink><br /><searchLink fieldCode="DE" term="%22Posture%22">Posture</searchLink><br /><searchLink fieldCode="DE" term="%22Confidence+intervals%22">Confidence intervals</searchLink><br /><searchLink fieldCode="DE" term="%22Data+analysis+software%22">Data analysis software</searchLink><br /><searchLink fieldCode="DE" term="%22Psychosocial+factors%22">Psychosocial factors</searchLink><br /><searchLink fieldCode="DE" term="%22Spine+diseases%22">Spine diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Time%22">Time</searchLink>
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  Label: Geographic Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Japan%22">Japan</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objectives The association between paternal occupational radiation exposure and the sex ratio of offspring remains controversial. Therefore, we aimed to explore testicular radiation exposure in spine surgeons and its association with their offspring's sex ratio. Methods The Minimally Invasive Spine Treatment Society in Japan administered a survey in October 2020. Male surgeons were divided into high- and low-radiation exposure groups according to the type of lead protectors used during the time frame surrounding the child's conception. Apron-type lead protectors were associated with high exposure, while no radiation or using a coat-type protector was considered low exposure. Risk ratios were calculated via generalized estimating equations with a log link binomial distribution. A secondary analysis was conducted wherein the high-exposure group was further divided into 2 categories based on whether they were in a posture that facilitated exposure during the procedures. Results A total of 209 male surgeons participated, providing responses regarding 436 children, of which 308 and 128 were associated with high and low radiation exposure, respectively. There were more female children in the high-exposure group (53% versus 39%). The adjusted risk ratio for the child being female with high exposure was 1.35 (95% CI: 1.04 to 1.73). A dose–response relationship was observed: the adjusted risk ratios for high exposure with and without an exposure-prone posture were 1.36 (1.04 to 1.78) and 1.30 (0.96 to 1.78), respectively. Conclusions High radiation exposure to the testes is associated with a lower male-sex ratio in offspring. Medical professionals using radiation should ensure proper radiation protection. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
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  Data: <i>Copyright of Annals of Work Exposures & Health is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1093/annweh/wxae093
    Languages:
      – Code: eng
        Text: English
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        PageCount: 9
        StartPage: 544
    Subjects:
      – SubjectFull: Behavioral assessment
        Type: general
      – SubjectFull: Radiation protection
        Type: general
      – SubjectFull: Dose-response relationship (Radiation)
        Type: general
      – SubjectFull: Risk assessment
        Type: general
      – SubjectFull: Secondary analysis
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      – SubjectFull: Spermatozoa
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      – SubjectFull: Radiation
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      – SubjectFull: Sex ratio
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      – SubjectFull: Occupational exposure
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      – SubjectFull: Fathers
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      – SubjectFull: Confidence intervals
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      – SubjectFull: Japan
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      – TitleFull: Association of occupational testicular radiation exposure with offspring sex ratio.
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