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Diagnostic performance of contrast-enhanced US in small liver nodules not conclusively characterized after MRI in cirrhotic patients.

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Title: Diagnostic performance of contrast-enhanced US in small liver nodules not conclusively characterized after MRI in cirrhotic patients.
Authors: Saborido, Belén1 (AUTHOR), Darnell, Anna1 (AUTHOR), Forner, Alejandro2,3,4 (AUTHOR), García-Criado, Ángeles1,3,4,5 (AUTHOR), Díaz, Alba3,5,6 (AUTHOR), Ayuso, Carmen1,3,5 (AUTHOR), Vilana, Ramon1 (AUTHOR), Bruix, Jordi3 (AUTHOR), Reig, María2,3,4,5 (AUTHOR), Rimola, Jordi1,3,4 (AUTHOR) jrimola@clinic.cat
Source: European Radiology. Sep2025, Vol. 35 Issue 9, p5771-5780. 10p.
Subjects: Contrast-enhanced ultrasound, Hepatocellular carcinoma, Liver tumors, Diagnostic examinations, Noninvasive diagnostic tests, Cirrhosis of the liver, Magnetic resonance imaging
Abstract: Objective: In patients at risk of hepatocellular carcinoma (HCC), new focal liver lesions identified at ultrasound screening require further characterization by CT or MRI. If these techniques cannot conclusively characterize a lesion, a biopsy or an alternative imaging modality such as contrast-enhanced ultrasound (CEUS) is considered. We aimed to determine the diagnostic yield of CEUS in a sequential noninvasive diagnostic strategy for solitary nodules ≤ 20 mm detected in cirrhotic patients during US surveillance characterized as inconclusive on MRI. Methods: Post hoc analysis of a single-center prospective cohort of high-risk patients (Child A or B) with no prior history of HCC and new liver nodules (≤ 20 mm) detected on screening US who underwent CEUS after inconclusive MRI (LI-RADS-2, LI-RADS-3, LI-RADS-4, or LI-RADS-M) between January 2006 and February 2017. We compared the characterization of nodules by LI-RADS v.2018 alone vs characterization after considering subsequent CEUS-LR v.2017 against the final diagnosis by biopsy or follow-up. Results: Of the 75 nodules included, CEUS upgraded 45 (63.4%); of these, 13 nodules classified as LR3 or LR4 at MRI were classified as CEUS-LR5. Altogether, 15 (21.1%) nodules inconclusive on MRI were classified as CEUS-LR5. CEUS yielded 37.5% (95% CI: 22.73‒54.20%) sensitivity and 100% specificity (95% CI: 88.78–100%) for HCC. Conclusion: Adding CEUS to the workup of liver nodules with inconclusive MRI findings demonstrated high specificity for HCC, particularly benefiting nodules categorized as LR3 at MRI. Key Points: QuestionMRI's limited sensitivity in diagnosing small HCCs in cirrhotic patients results in inconclusive classification of a high proportion of screening-detected lesions. FindingsAdding CEUS to the work-up for inconclusive liver nodules at MRI yielded 100% specificity (95% CI: 88.78–100%) and 37.5% (95% CI: 22.73–54.20%) sensitivity for the HCC diagnosis. Clinical relevanceCEUS is a valuable problem-solving tool in the work-up of small liver nodules with inconclusive MRI findings in cirrhotic patients. [ABSTRACT FROM AUTHOR]
Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Diagnostic performance of contrast-enhanced US in small liver nodules not conclusively characterized after MRI in cirrhotic patients.
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  Data: <searchLink fieldCode="AR" term="%22Saborido%2C+Belén%22">Saborido, Belén</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Darnell%2C+Anna%22">Darnell, Anna</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Forner%2C+Alejandro%22">Forner, Alejandro</searchLink><relatesTo>2,3,4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22García-Criado%2C+Ángeles%22">García-Criado, Ángeles</searchLink><relatesTo>1,3,4,5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Díaz%2C+Alba%22">Díaz, Alba</searchLink><relatesTo>3,5,6</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ayuso%2C+Carmen%22">Ayuso, Carmen</searchLink><relatesTo>1,3,5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Vilana%2C+Ramon%22">Vilana, Ramon</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bruix%2C+Jordi%22">Bruix, Jordi</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Reig%2C+María%22">Reig, María</searchLink><relatesTo>2,3,4,5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rimola%2C+Jordi%22">Rimola, Jordi</searchLink><relatesTo>1,3,4</relatesTo> (AUTHOR)<i> jrimola@clinic.cat</i>
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  Data: <searchLink fieldCode="JN" term="%22European+Radiology%22">European Radiology</searchLink>. Sep2025, Vol. 35 Issue 9, p5771-5780. 10p.
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  Data: <searchLink fieldCode="DE" term="%22Contrast-enhanced+ultrasound%22">Contrast-enhanced ultrasound</searchLink><br /><searchLink fieldCode="DE" term="%22Hepatocellular+carcinoma%22">Hepatocellular carcinoma</searchLink><br /><searchLink fieldCode="DE" term="%22Liver+tumors%22">Liver tumors</searchLink><br /><searchLink fieldCode="DE" term="%22Diagnostic+examinations%22">Diagnostic examinations</searchLink><br /><searchLink fieldCode="DE" term="%22Noninvasive+diagnostic+tests%22">Noninvasive diagnostic tests</searchLink><br /><searchLink fieldCode="DE" term="%22Cirrhosis+of+the+liver%22">Cirrhosis of the liver</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objective: In patients at risk of hepatocellular carcinoma (HCC), new focal liver lesions identified at ultrasound screening require further characterization by CT or MRI. If these techniques cannot conclusively characterize a lesion, a biopsy or an alternative imaging modality such as contrast-enhanced ultrasound (CEUS) is considered. We aimed to determine the diagnostic yield of CEUS in a sequential noninvasive diagnostic strategy for solitary nodules ≤ 20 mm detected in cirrhotic patients during US surveillance characterized as inconclusive on MRI. Methods: Post hoc analysis of a single-center prospective cohort of high-risk patients (Child A or B) with no prior history of HCC and new liver nodules (≤ 20 mm) detected on screening US who underwent CEUS after inconclusive MRI (LI-RADS-2, LI-RADS-3, LI-RADS-4, or LI-RADS-M) between January 2006 and February 2017. We compared the characterization of nodules by LI-RADS v.2018 alone vs characterization after considering subsequent CEUS-LR v.2017 against the final diagnosis by biopsy or follow-up. Results: Of the 75 nodules included, CEUS upgraded 45 (63.4%); of these, 13 nodules classified as LR3 or LR4 at MRI were classified as CEUS-LR5. Altogether, 15 (21.1%) nodules inconclusive on MRI were classified as CEUS-LR5. CEUS yielded 37.5% (95% CI: 22.73‒54.20%) sensitivity and 100% specificity (95% CI: 88.78–100%) for HCC. Conclusion: Adding CEUS to the workup of liver nodules with inconclusive MRI findings demonstrated high specificity for HCC, particularly benefiting nodules categorized as LR3 at MRI. Key Points: QuestionMRI's limited sensitivity in diagnosing small HCCs in cirrhotic patients results in inconclusive classification of a high proportion of screening-detected lesions. FindingsAdding CEUS to the work-up for inconclusive liver nodules at MRI yielded 100% specificity (95% CI: 88.78–100%) and 37.5% (95% CI: 22.73–54.20%) sensitivity for the HCC diagnosis. Clinical relevanceCEUS is a valuable problem-solving tool in the work-up of small liver nodules with inconclusive MRI findings in cirrhotic patients. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1007/s00330-025-11495-3
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        Text: English
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      – SubjectFull: Contrast-enhanced ultrasound
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              Text: Sep2025
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