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Carotid artery atherosclerosis and white matter lesions in the elderly: a community-based MR imaging study.

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Title: Carotid artery atherosclerosis and white matter lesions in the elderly: a community-based MR imaging study.
Authors: Cai, Ying1 (AUTHOR), Liu, Yang2 (AUTHOR), Qiao, Huiyu3 (AUTHOR), Chen, Huijun4 (AUTHOR), Li, Rui4 (AUTHOR), Zhang, Ji1 (AUTHOR) zhangji20230206@njmu.edu.cn, Zhao, Xihai4 (AUTHOR) xihaizhao@tsinghua.edu.cn
Source: European Radiology. Sep2025, Vol. 35 Issue 9, p5561-5568. 8p.
Subjects: Carotid artery, Atherosclerotic plaque, Atherosclerosis, Cerebral small vessel diseases, Magnetic resonance imaging, Health of older people, Leukoencephalopathies, Older people
Abstract: Objectives: This study sought to evaluate the relationship between morphological and compositional characteristics of carotid atherosclerotic plaques and white matter lesions (WMLs) in asymptomatic elderly adults using three-dimensional (3D) multicontrast magnetic resonance (MR) vessel wall imaging. Materials and methods: Asymptomatic elderly subjects (≥ 60 years) were recruited from a community-based study. Carotid arteries and the brain were imaged on a 3.0-T MR scanner. The morphological and compositional features of carotid atherosclerotic plaques were evaluated. The WMLs were scored using the Fazekas criteria. The characteristics of carotid plaque were compared among different WML severities and the associations between carotid plaque characteristics and WMLs were analyzed. Results: In total, 123 elderly subjects (mean age: 71.9 ± 6.0 years, 55 males) were included. A significant difference was found in carotid MWT, presence of calcification, and high-risk plaque among subjects with different severity of WMLs (all p < 0.05). Univariate logistic regression analysis showed that carotid plaque calcification (OR, 5.357; 95% CI: 1.556–18.437, p = 0.008), intraplaque hemorrhage (OR, 4.952; 95% CI: 1.089–22.514, p = 0.038), and high-risk plaque (OR, 7.214; 95% CI: 1.929–26.974, p = 0.003) in carotid arteries were significantly associated with severe WML. After adjusting for the confounding factors, the significance of these associations was attenuated and only the association of high-risk plaque with severe WML remained statistically significant (OR, 8.829; 95% CI: 1.566–49.787; p = 0.014). Conclusion: Carotid artery plaque compositional characteristics, especially high-risk plaque, were significantly associated with the severity of WMLs, suggesting that carotid vulnerable atherosclerotic plaque might be an independent indicator for cerebral small vessel disease in asymptomatic elderly adults. Key Points: QuestionThe relationship between carotid atherosclerotic plaque characteristics and WMLs in asymptomatic elderly adults remains unclear. FindingsHigh-risk carotid plaques are significantly associated with the severity of WMLs in the asymptomatic elderly. Clinical relevanceIdentifying carotid plaque characteristics, particularly high-risk plaques, may serve as an indicator for cerebral small vessel disease, aiding in early detection and management of related risks in the asymptomatic elderly. [ABSTRACT FROM AUTHOR]
Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Label: Title
  Group: Ti
  Data: Carotid artery atherosclerosis and white matter lesions in the elderly: a community-based MR imaging study.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Cai%2C+Ying%22&quot;&gt;Cai, Ying&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Liu%2C+Yang%22&quot;&gt;Liu, Yang&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Qiao%2C+Huiyu%22&quot;&gt;Qiao, Huiyu&lt;/searchLink&gt;&lt;relatesTo&gt;3&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Chen%2C+Huijun%22&quot;&gt;Chen, Huijun&lt;/searchLink&gt;&lt;relatesTo&gt;4&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Li%2C+Rui%22&quot;&gt;Li, Rui&lt;/searchLink&gt;&lt;relatesTo&gt;4&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Zhang%2C+Ji%22&quot;&gt;Zhang, Ji&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;i&gt; zhangji20230206@njmu.edu.cn&lt;/i&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Zhao%2C+Xihai%22&quot;&gt;Zhao, Xihai&lt;/searchLink&gt;&lt;relatesTo&gt;4&lt;/relatesTo&gt; (AUTHOR)&lt;i&gt; xihaizhao@tsinghua.edu.cn&lt;/i&gt;
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22European+Radiology%22&quot;&gt;European Radiology&lt;/searchLink&gt;. Sep2025, Vol. 35 Issue 9, p5561-5568. 8p.
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– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objectives: This study sought to evaluate the relationship between morphological and compositional characteristics of carotid atherosclerotic plaques and white matter lesions (WMLs) in asymptomatic elderly adults using three-dimensional (3D) multicontrast magnetic resonance (MR) vessel wall imaging. Materials and methods: Asymptomatic elderly subjects (≥ 60 years) were recruited from a community-based study. Carotid arteries and the brain were imaged on a 3.0-T MR scanner. The morphological and compositional features of carotid atherosclerotic plaques were evaluated. The WMLs were scored using the Fazekas criteria. The characteristics of carotid plaque were compared among different WML severities and the associations between carotid plaque characteristics and WMLs were analyzed. Results: In total, 123 elderly subjects (mean age: 71.9 &#177; 6.0 years, 55 males) were included. A significant difference was found in carotid MWT, presence of calcification, and high-risk plaque among subjects with different severity of WMLs (all p &lt; 0.05). Univariate logistic regression analysis showed that carotid plaque calcification (OR, 5.357; 95% CI: 1.556–18.437, p = 0.008), intraplaque hemorrhage (OR, 4.952; 95% CI: 1.089–22.514, p = 0.038), and high-risk plaque (OR, 7.214; 95% CI: 1.929–26.974, p = 0.003) in carotid arteries were significantly associated with severe WML. After adjusting for the confounding factors, the significance of these associations was attenuated and only the association of high-risk plaque with severe WML remained statistically significant (OR, 8.829; 95% CI: 1.566–49.787; p = 0.014). Conclusion: Carotid artery plaque compositional characteristics, especially high-risk plaque, were significantly associated with the severity of WMLs, suggesting that carotid vulnerable atherosclerotic plaque might be an independent indicator for cerebral small vessel disease in asymptomatic elderly adults. Key Points: QuestionThe relationship between carotid atherosclerotic plaque characteristics and WMLs in asymptomatic elderly adults remains unclear. FindingsHigh-risk carotid plaques are significantly associated with the severity of WMLs in the asymptomatic elderly. Clinical relevanceIdentifying carotid plaque characteristics, particularly high-risk plaques, may serve as an indicator for cerebral small vessel disease, aiding in early detection and management of related risks in the asymptomatic elderly. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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        Value: 10.1007/s00330-025-11509-0
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        Text: English
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    Subjects:
      – SubjectFull: Carotid artery
        Type: general
      – SubjectFull: Atherosclerotic plaque
        Type: general
      – SubjectFull: Atherosclerosis
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      – SubjectFull: Cerebral small vessel diseases
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      – SubjectFull: Magnetic resonance imaging
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      – SubjectFull: Health of older people
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      – SubjectFull: Leukoencephalopathies
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      – SubjectFull: Older people
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      – TitleFull: Carotid artery atherosclerosis and white matter lesions in the elderly: a community-based MR imaging study.
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              M: 09
              Text: Sep2025
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