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Design and Evaluation of a Inonotus obliquus –AgNP–Maltodextrin Delivery System: Antioxidant, Antimicrobial, Acetylcholinesterase Inhibitory and Cytotoxic Potential.

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Title: Design and Evaluation of a Inonotus obliquus –AgNP–Maltodextrin Delivery System: Antioxidant, Antimicrobial, Acetylcholinesterase Inhibitory and Cytotoxic Potential.
Authors: Stanoiu, Ana-Maria1 (AUTHOR), Bejenaru, Cornelia2,3 (AUTHOR), Segneanu, Adina-Elena3,4 (AUTHOR) adina.segneanu@e-uvt.ro, Vlase, Gabriela4,5 (AUTHOR), Bradu, Ionela Amalia4,5 (AUTHOR), Vlase, Titus4,5,6 (AUTHOR), Mogoşanu, George Dan2,6,7 (AUTHOR), Ciocîlteu, Maria Viorica2,7,8 (AUTHOR), Biţă, Andrei2,6,9 (AUTHOR), Kostici, Roxana1,2,8 (AUTHOR), Herea, Dumitru-Daniel2,9 (AUTHOR), Bejenaru, Ludovic Everard2,3,6 (AUTHOR)
Source: Polymers (20734360). Aug2025, Vol. 17 Issue 15, p2163. 52p.
Subjects: Maltodextrin, Antioxidants, Silver nanoparticles, Polyporaceae, Acetylcholinesterase inhibitors, Nanocapsules, Cytotoxins, Anti-infective agents
Abstract: Inonotus obliquus, a medicinal mushroom valued for its bioactive compounds, has not been previously characterized from Romanian sources. This study presents the first comprehensive chemical and biological screening of I. obliquus, introducing novel polymer-based encapsulation systems to enhance the stability and bioavailability of its bioactive constituents. Two distinct delivery systems were designed to enhance the functionality of I. obliquus extracts: (i) microencapsulation in maltodextrin (MIO) and (ii) a sequential approach involving preparation of silver nanoparticle-loaded I. obliquus (IO–AgNPs), followed by microencapsulation to yield the hybrid MIO–AgNP system. Comprehensive metabolite profiling using GC–MS and ESI–QTOF–MS revealed 142 bioactive constituents, including terpenoids, flavonoids, phenolic acids, amino acids, coumarins, styrylpyrones, fatty acids, and phytosterols. Structural integrity and successful encapsulation were confirmed by XRD, FTIR, and SEM analyses. Both IO–AgNPs and MIO–AgNPs demonstrated potent antioxidant activity, significant acetylcholinesterase inhibition, and robust antimicrobial effects against Staphylococcus aureus, Bacillus cereus, Pseudomonas aeruginosa, and Escherichia coli. Cytotoxicity assays revealed pronounced activity against MCF-7, HCT116, and HeLa cell lines, with MIO–AgNPs exhibiting superior efficacy. The synergistic integration of maltodextrin and AgNPs enhanced compound stability and bioactivity. As the first report on Romanian I. obliquus, this study highlights its therapeutic potential and establishes polymer-based nanoencapsulation as an effective strategy for optimizing its applications in combating microbial resistance and cancer. [ABSTRACT FROM AUTHOR]
Copyright of Polymers (20734360) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Design and Evaluation of a Inonotus obliquus –AgNP–Maltodextrin Delivery System: Antioxidant, Antimicrobial, Acetylcholinesterase Inhibitory and Cytotoxic Potential.
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  Data: <searchLink fieldCode="AR" term="%22Stanoiu%2C+Ana-Maria%22">Stanoiu, Ana-Maria</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bejenaru%2C+Cornelia%22">Bejenaru, Cornelia</searchLink><relatesTo>2,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Segneanu%2C+Adina-Elena%22">Segneanu, Adina-Elena</searchLink><relatesTo>3,4</relatesTo> (AUTHOR)<i> adina.segneanu@e-uvt.ro</i><br /><searchLink fieldCode="AR" term="%22Vlase%2C+Gabriela%22">Vlase, Gabriela</searchLink><relatesTo>4,5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bradu%2C+Ionela+Amalia%22">Bradu, Ionela Amalia</searchLink><relatesTo>4,5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Vlase%2C+Titus%22">Vlase, Titus</searchLink><relatesTo>4,5,6</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mogoşanu%2C+George+Dan%22">Mogoşanu, George Dan</searchLink><relatesTo>2,6,7</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ciocîlteu%2C+Maria+Viorica%22">Ciocîlteu, Maria Viorica</searchLink><relatesTo>2,7,8</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Biţă%2C+Andrei%22">Biţă, Andrei</searchLink><relatesTo>2,6,9</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kostici%2C+Roxana%22">Kostici, Roxana</searchLink><relatesTo>1,2,8</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Herea%2C+Dumitru-Daniel%22">Herea, Dumitru-Daniel</searchLink><relatesTo>2,9</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bejenaru%2C+Ludovic+Everard%22">Bejenaru, Ludovic Everard</searchLink><relatesTo>2,3,6</relatesTo> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Polymers+%2820734360%29%22">Polymers (20734360)</searchLink>. Aug2025, Vol. 17 Issue 15, p2163. 52p.
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– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Inonotus obliquus, a medicinal mushroom valued for its bioactive compounds, has not been previously characterized from Romanian sources. This study presents the first comprehensive chemical and biological screening of I. obliquus, introducing novel polymer-based encapsulation systems to enhance the stability and bioavailability of its bioactive constituents. Two distinct delivery systems were designed to enhance the functionality of I. obliquus extracts: (i) microencapsulation in maltodextrin (MIO) and (ii) a sequential approach involving preparation of silver nanoparticle-loaded I. obliquus (IO–AgNPs), followed by microencapsulation to yield the hybrid MIO–AgNP system. Comprehensive metabolite profiling using GC–MS and ESI–QTOF–MS revealed 142 bioactive constituents, including terpenoids, flavonoids, phenolic acids, amino acids, coumarins, styrylpyrones, fatty acids, and phytosterols. Structural integrity and successful encapsulation were confirmed by XRD, FTIR, and SEM analyses. Both IO–AgNPs and MIO–AgNPs demonstrated potent antioxidant activity, significant acetylcholinesterase inhibition, and robust antimicrobial effects against Staphylococcus aureus, Bacillus cereus, Pseudomonas aeruginosa, and Escherichia coli. Cytotoxicity assays revealed pronounced activity against MCF-7, HCT116, and HeLa cell lines, with MIO–AgNPs exhibiting superior efficacy. The synergistic integration of maltodextrin and AgNPs enhanced compound stability and bioactivity. As the first report on Romanian I. obliquus, this study highlights its therapeutic potential and establishes polymer-based nanoencapsulation as an effective strategy for optimizing its applications in combating microbial resistance and cancer. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Polymers (20734360) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.3390/polym17152163
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      – Code: eng
        Text: English
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        PageCount: 52
        StartPage: 2163
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      – SubjectFull: Maltodextrin
        Type: general
      – SubjectFull: Antioxidants
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      – SubjectFull: Silver nanoparticles
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      – SubjectFull: Polyporaceae
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      – SubjectFull: Acetylcholinesterase inhibitors
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      – SubjectFull: Nanocapsules
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      – TitleFull: Design and Evaluation of a Inonotus obliquus –AgNP–Maltodextrin Delivery System: Antioxidant, Antimicrobial, Acetylcholinesterase Inhibitory and Cytotoxic Potential.
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              Text: Aug2025
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