Nanocarriers for Medical Ozone Delivery: A New Therapeutic Strategy.
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| Title: | Nanocarriers for Medical Ozone Delivery: A New Therapeutic Strategy. |
|---|---|
| Authors: | Malatesta, Manuela1 (AUTHOR) manuela.malatesta@univr.it, Carton, Flavia2,3 (AUTHOR) |
| Source: | Nanomaterials (2079-4991). Aug2025, Vol. 15 Issue 15, p1188. 18p. |
| Subjects: | Ozone, Nanocarriers, Ozone therapy, Antibacterial agents, Nanotechnology, Regeneration (Biology), Therapeutics |
| Abstract: | Ozone (O3) occurs in nature as a chemical compound made of three oxygen atoms. It is an unstable, highly oxidative gas that rapidly decomposes into oxygen. The therapeutic use of O3 dates back to the beginning of the 20th century and is currently based on the application of low doses, inducing a moderate oxidative stress that stimulates the antioxidant cellular defenses without causing cell damage. Low O3 doses also induce anti-inflammatory and regenerative effects, and their anticancer potential is under investigation. In addition, the oxidative properties of O3 make it an excellent antibacterial, antimycotic, and antiviral agent. Thanks to these properties, O3 is currently widely used in several medical fields. However, its chemical instability represents an application limit, and ozonated oil is the only stabilized form of medical O3. In recent years, novel O3 formulations have been proposed for their sustained and more efficient administration, based on nanotechnology. This review offers an overview of the nanocarriers designed for the delivery of medical O3, and of their therapeutic applications. The reviewed articles demonstrate that research is active and productive, though it is a rather new entry in the nanotechnological field. Liposomes, nanobubbles, nanoconstructed hydrogels, polymeric nanoparticles, and niosomes were designed to deliver O3 and have been proven to exert antiseptic, anticancer, and pro-regenerative effects when administered in vitro and in vivo. Improving the therapeutic administration of O3 through nanocarriers is a just-started challenge, and multiple prospects may be foreseen. [ABSTRACT FROM AUTHOR] |
| Copyright of Nanomaterials (2079-4991) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
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| Header | DbId: egs DbLabel: Engineering Source An: 187316598 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Nanocarriers for Medical Ozone Delivery: A New Therapeutic Strategy. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Malatesta%2C+Manuela%22">Malatesta, Manuela</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> manuela.malatesta@univr.it</i><br /><searchLink fieldCode="AR" term="%22Carton%2C+Flavia%22">Carton, Flavia</searchLink><relatesTo>2,3</relatesTo> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Nanomaterials+%282079-4991%29%22">Nanomaterials (2079-4991)</searchLink>. Aug2025, Vol. 15 Issue 15, p1188. 18p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Ozone%22">Ozone</searchLink><br /><searchLink fieldCode="DE" term="%22Nanocarriers%22">Nanocarriers</searchLink><br /><searchLink fieldCode="DE" term="%22Ozone+therapy%22">Ozone therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Antibacterial+agents%22">Antibacterial agents</searchLink><br /><searchLink fieldCode="DE" term="%22Nanotechnology%22">Nanotechnology</searchLink><br /><searchLink fieldCode="DE" term="%22Regeneration+%28Biology%29%22">Regeneration (Biology)</searchLink><br /><searchLink fieldCode="DE" term="%22Therapeutics%22">Therapeutics</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Ozone (O3) occurs in nature as a chemical compound made of three oxygen atoms. It is an unstable, highly oxidative gas that rapidly decomposes into oxygen. The therapeutic use of O3 dates back to the beginning of the 20th century and is currently based on the application of low doses, inducing a moderate oxidative stress that stimulates the antioxidant cellular defenses without causing cell damage. Low O3 doses also induce anti-inflammatory and regenerative effects, and their anticancer potential is under investigation. In addition, the oxidative properties of O3 make it an excellent antibacterial, antimycotic, and antiviral agent. Thanks to these properties, O3 is currently widely used in several medical fields. However, its chemical instability represents an application limit, and ozonated oil is the only stabilized form of medical O3. In recent years, novel O3 formulations have been proposed for their sustained and more efficient administration, based on nanotechnology. This review offers an overview of the nanocarriers designed for the delivery of medical O3, and of their therapeutic applications. The reviewed articles demonstrate that research is active and productive, though it is a rather new entry in the nanotechnological field. Liposomes, nanobubbles, nanoconstructed hydrogels, polymeric nanoparticles, and niosomes were designed to deliver O3 and have been proven to exert antiseptic, anticancer, and pro-regenerative effects when administered in vitro and in vivo. Improving the therapeutic administration of O3 through nanocarriers is a just-started challenge, and multiple prospects may be foreseen. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Nanomaterials (2079-4991) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.3390/nano15151188 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 18 StartPage: 1188 Subjects: – SubjectFull: Ozone Type: general – SubjectFull: Nanocarriers Type: general – SubjectFull: Ozone therapy Type: general – SubjectFull: Antibacterial agents Type: general – SubjectFull: Nanotechnology Type: general – SubjectFull: Regeneration (Biology) Type: general – SubjectFull: Therapeutics Type: general Titles: – TitleFull: Nanocarriers for Medical Ozone Delivery: A New Therapeutic Strategy. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Malatesta, Manuela – PersonEntity: Name: NameFull: Carton, Flavia IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 08 Text: Aug2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 20794991 Numbering: – Type: volume Value: 15 – Type: issue Value: 15 Titles: – TitleFull: Nanomaterials (2079-4991) Type: main |
| ResultId | 1 |
