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Genetic and bioactive functionalization of bioinks for 3D bioprinting.

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Title: Genetic and bioactive functionalization of bioinks for 3D bioprinting.
Authors: Kumar, Pawan1 (AUTHOR) pawankamiya@yahoo.in, Sharma, Jitender1 (AUTHOR) jksharmakuk@rediffmail.com, Kumar, Ravinder2 (AUTHOR) rav.chauhan@yahoo.co.in, Najser, Jan3 (AUTHOR) jan.najser@vsb.cz, Frantik, Jaroslav3 (AUTHOR) jaroslav.frantik@vsb.cz, Sunnam, Nagaraju4 (AUTHOR) nagaraju.raju02@gmail.com, Sindhu, Anil5 (AUTHOR) sindhu.biotech@gmail.com, Praveenkumar, Seepana6 (AUTHOR) seepanapraveenkumar5@gmail.com
Source: Bioprocess & Biosystems Engineering. Sep2025, Vol. 48 Issue 9, p1421-1449. 29p.
Subjects: Genetic engineering, Tissue engineering, Bioprinting, Growth factors, Biocompatibility, Regenerative medicine
Abstract: 3D bioprinting is revolutionizing tissue engineering and regenerative medicine by enabling the precise fabrication of biologically functional constructs. At its core, the success of 3D bioprinting hinges on the development of bioinks, hydrogel-based materials that support cellular viability, proliferation, and differentiation. However, conventional bioinks face limitations in mechanical strength, biological activity, and customization. Recent advancements in genetic engineering have addressed these challenges by enhancing the properties of bioinks through genetic modifications. These innovations allow the integration of stimuli-responsive elements, bioactive molecules, and extracellular matrix (ECM) components, significantly improving the mechanical integrity, biocompatibility, and functional adaptability of bioinks. This review explores the state-of-the-art genetic approaches to bioink development, emphasizing microbial engineering, genetic functionalization, and the encapsulation of growth factors. It highlights the transformative potential of genetically modified bioinks in various applications, including bone and cartilage regeneration, cardiac and liver tissue engineering, neural tissue reconstruction, and vascularization. While these advances hold promise for personalized and adaptive therapeutic solutions, challenges in scalability, reproducibility, and integration with multi-material systems persist. By bridging genetics and bioprinting, this interdisciplinary field paves the way for sophisticated constructs and innovative therapies in tissue engineering and regenerative medicine. [ABSTRACT FROM AUTHOR]
Copyright of Bioprocess & Biosystems Engineering is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Genetic and bioactive functionalization of bioinks for 3D bioprinting.
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  Data: <searchLink fieldCode="AR" term="%22Kumar%2C+Pawan%22">Kumar, Pawan</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> pawankamiya@yahoo.in</i><br /><searchLink fieldCode="AR" term="%22Sharma%2C+Jitender%22">Sharma, Jitender</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> jksharmakuk@rediffmail.com</i><br /><searchLink fieldCode="AR" term="%22Kumar%2C+Ravinder%22">Kumar, Ravinder</searchLink><relatesTo>2</relatesTo> (AUTHOR)<i> rav.chauhan@yahoo.co.in</i><br /><searchLink fieldCode="AR" term="%22Najser%2C+Jan%22">Najser, Jan</searchLink><relatesTo>3</relatesTo> (AUTHOR)<i> jan.najser@vsb.cz</i><br /><searchLink fieldCode="AR" term="%22Frantik%2C+Jaroslav%22">Frantik, Jaroslav</searchLink><relatesTo>3</relatesTo> (AUTHOR)<i> jaroslav.frantik@vsb.cz</i><br /><searchLink fieldCode="AR" term="%22Sunnam%2C+Nagaraju%22">Sunnam, Nagaraju</searchLink><relatesTo>4</relatesTo> (AUTHOR)<i> nagaraju.raju02@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Sindhu%2C+Anil%22">Sindhu, Anil</searchLink><relatesTo>5</relatesTo> (AUTHOR)<i> sindhu.biotech@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Praveenkumar%2C+Seepana%22">Praveenkumar, Seepana</searchLink><relatesTo>6</relatesTo> (AUTHOR)<i> seepanapraveenkumar5@gmail.com</i>
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  Data: <searchLink fieldCode="JN" term="%22Bioprocess+%26+Biosystems+Engineering%22">Bioprocess & Biosystems Engineering</searchLink>. Sep2025, Vol. 48 Issue 9, p1421-1449. 29p.
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  Data: <searchLink fieldCode="DE" term="%22Genetic+engineering%22">Genetic engineering</searchLink><br /><searchLink fieldCode="DE" term="%22Tissue+engineering%22">Tissue engineering</searchLink><br /><searchLink fieldCode="DE" term="%22Bioprinting%22">Bioprinting</searchLink><br /><searchLink fieldCode="DE" term="%22Growth+factors%22">Growth factors</searchLink><br /><searchLink fieldCode="DE" term="%22Biocompatibility%22">Biocompatibility</searchLink><br /><searchLink fieldCode="DE" term="%22Regenerative+medicine%22">Regenerative medicine</searchLink>
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  Data: 3D bioprinting is revolutionizing tissue engineering and regenerative medicine by enabling the precise fabrication of biologically functional constructs. At its core, the success of 3D bioprinting hinges on the development of bioinks, hydrogel-based materials that support cellular viability, proliferation, and differentiation. However, conventional bioinks face limitations in mechanical strength, biological activity, and customization. Recent advancements in genetic engineering have addressed these challenges by enhancing the properties of bioinks through genetic modifications. These innovations allow the integration of stimuli-responsive elements, bioactive molecules, and extracellular matrix (ECM) components, significantly improving the mechanical integrity, biocompatibility, and functional adaptability of bioinks. This review explores the state-of-the-art genetic approaches to bioink development, emphasizing microbial engineering, genetic functionalization, and the encapsulation of growth factors. It highlights the transformative potential of genetically modified bioinks in various applications, including bone and cartilage regeneration, cardiac and liver tissue engineering, neural tissue reconstruction, and vascularization. While these advances hold promise for personalized and adaptive therapeutic solutions, challenges in scalability, reproducibility, and integration with multi-material systems persist. By bridging genetics and bioprinting, this interdisciplinary field paves the way for sophisticated constructs and innovative therapies in tissue engineering and regenerative medicine. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Bioprocess & Biosystems Engineering is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Text: English
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    Subjects:
      – SubjectFull: Genetic engineering
        Type: general
      – SubjectFull: Tissue engineering
        Type: general
      – SubjectFull: Bioprinting
        Type: general
      – SubjectFull: Growth factors
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      – SubjectFull: Biocompatibility
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      – SubjectFull: Regenerative medicine
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      – TitleFull: Genetic and bioactive functionalization of bioinks for 3D bioprinting.
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              M: 09
              Text: Sep2025
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