Simultaneous liver T1, T2, and ADC MR fingerprinting using optimized motion‐compensated diffusion preparations: An initial validation on volunteers.
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| Title: | Simultaneous liver T |
|---|---|
| Authors: | Velasco, C.1 (AUTHOR) claudia.prieto@kcl.ac.uk, Castillo‐Passi, C.1,2,3 (AUTHOR), Chaher, N.1 (AUTHOR), Karampinos, D. C.4 (AUTHOR), Irarrazaval, P.2,3,5 (AUTHOR), Phinikaridou, A.1 (AUTHOR), Botnar, R. M.1,2,3,5 (AUTHOR), Prieto, C.1,3,5 (AUTHOR) |
| Source: | Magnetic Resonance in Medicine. Nov2025, Vol. 94 Issue 5, p2173-2189. 17p. |
| Subjects: | Magnetic resonance imaging, Motion compensation (Signal processing), Diffusion measurements, Liver diseases, Computer-assisted image analysis (Medicine) |
| Abstract: | Purpose: To develop a novel MR fingerprinting sequence using optimized motion‐compensated diffusion preparations for simultaneous T1, T2, and ADC quantification of liver tissue in a single breath‐held scan. Methods: A radial spoiled gradient echo acquisition with magnetization preparation modules for T1, T2, and ADC encoding is proposed. To compensate for the signal voids generated by the diffusion preparation, the combination of (1) a breath‐held scan, (2) peripheral pulse signal triggering, and (3) an optimized motion‐compensated diffusion‐preparation module is employed. Phantom experiments were performed to test the accuracy of the technique. The sequence was evaluated in 11 healthy subjects in comparison to conventional mapping techniques. Additional in vivo repeatability assessment experiments were performed. Results: T1, T2, and ADC quantification showed good correlation (r2 > 0.9 for all cases) with reference maps in phantoms and good agreement in vivo against clinical scans (bias not significantly different from zero). A peripheral pulse trigger delay of 200 ms was used to reduce cardiovascular motion artifacts. The repeatability tests prove a low interscan coefficient of variation and a high intraclass correlation coefficient of greater than 0.9 for all cases. Conclusions: Simultaneous quantification of T1, T2, and ADC in liver tissue in a single MR fingerprinting scan of ˜16 s has been proposed, enabling a comprehensive evaluation of hepatic disease through co‐registered multiparametric imaging. Further studies are warranted to test this approach in patients with suspected diffuse liver disease to evaluate its potential for liver tissue characterization and tumor staging. [ABSTRACT FROM AUTHOR] |
| Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 187617633 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Simultaneous liver T<subscript>1</subscript>, T<subscript>2</subscript>, and ADC MR fingerprinting using optimized motion‐compensated diffusion preparations: An initial validation on volunteers. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Velasco%2C+C%2E%22">Velasco, C.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> claudia.prieto@kcl.ac.uk</i><br /><searchLink fieldCode="AR" term="%22Castillo‐Passi%2C+C%2E%22">Castillo‐Passi, C.</searchLink><relatesTo>1,2,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chaher%2C+N%2E%22">Chaher, N.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Karampinos%2C+D%2E+C%2E%22">Karampinos, D. C.</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Irarrazaval%2C+P%2E%22">Irarrazaval, P.</searchLink><relatesTo>2,3,5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Phinikaridou%2C+A%2E%22">Phinikaridou, A.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Botnar%2C+R%2E+M%2E%22">Botnar, R. M.</searchLink><relatesTo>1,2,3,5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Prieto%2C+C%2E%22">Prieto, C.</searchLink><relatesTo>1,3,5</relatesTo> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Magnetic+Resonance+in+Medicine%22">Magnetic Resonance in Medicine</searchLink>. Nov2025, Vol. 94 Issue 5, p2173-2189. 17p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Motion+compensation+%28Signal+processing%29%22">Motion compensation (Signal processing)</searchLink><br /><searchLink fieldCode="DE" term="%22Diffusion+measurements%22">Diffusion measurements</searchLink><br /><searchLink fieldCode="DE" term="%22Liver+diseases%22">Liver diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Computer-assisted+image+analysis+%28Medicine%29%22">Computer-assisted image analysis (Medicine)</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Purpose: To develop a novel MR fingerprinting sequence using optimized motion‐compensated diffusion preparations for simultaneous T1, T2, and ADC quantification of liver tissue in a single breath‐held scan. Methods: A radial spoiled gradient echo acquisition with magnetization preparation modules for T1, T2, and ADC encoding is proposed. To compensate for the signal voids generated by the diffusion preparation, the combination of (1) a breath‐held scan, (2) peripheral pulse signal triggering, and (3) an optimized motion‐compensated diffusion‐preparation module is employed. Phantom experiments were performed to test the accuracy of the technique. The sequence was evaluated in 11 healthy subjects in comparison to conventional mapping techniques. Additional in vivo repeatability assessment experiments were performed. Results: T1, T2, and ADC quantification showed good correlation (r2 > 0.9 for all cases) with reference maps in phantoms and good agreement in vivo against clinical scans (bias not significantly different from zero). A peripheral pulse trigger delay of 200 ms was used to reduce cardiovascular motion artifacts. The repeatability tests prove a low interscan coefficient of variation and a high intraclass correlation coefficient of greater than 0.9 for all cases. Conclusions: Simultaneous quantification of T1, T2, and ADC in liver tissue in a single MR fingerprinting scan of ˜16 s has been proposed, enabling a comprehensive evaluation of hepatic disease through co‐registered multiparametric imaging. Further studies are warranted to test this approach in patients with suspected diffuse liver disease to evaluate its potential for liver tissue characterization and tumor staging. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/mrm.30622 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 17 StartPage: 2173 Subjects: – SubjectFull: Magnetic resonance imaging Type: general – SubjectFull: Motion compensation (Signal processing) Type: general – SubjectFull: Diffusion measurements Type: general – SubjectFull: Liver diseases Type: general – SubjectFull: Computer-assisted image analysis (Medicine) Type: general Titles: – TitleFull: Simultaneous liver T1, T2, and ADC MR fingerprinting using optimized motion‐compensated diffusion preparations: An initial validation on volunteers. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Velasco, C. – PersonEntity: Name: NameFull: Castillo‐Passi, C. – PersonEntity: Name: NameFull: Chaher, N. – PersonEntity: Name: NameFull: Karampinos, D. C. – PersonEntity: Name: NameFull: Irarrazaval, P. – PersonEntity: Name: NameFull: Phinikaridou, A. – PersonEntity: Name: NameFull: Botnar, R. M. – PersonEntity: Name: NameFull: Prieto, C. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 11 Text: Nov2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 07403194 Numbering: – Type: volume Value: 94 – Type: issue Value: 5 Titles: – TitleFull: Magnetic Resonance in Medicine Type: main |
| ResultId | 1 |
