Gum arabic in drug delivery systems: A route-specific overview and functional insights.
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| Title: | Gum arabic in drug delivery systems: A route-specific overview and functional insights. |
|---|---|
| Authors: | Patel, Rutu1 (AUTHOR), Khumkar, Rucha1 (AUTHOR), Suvarna, Vasanti1 (AUTHOR) vasanti.suvarna@bncp.ac.in |
| Source: | Carbohydrate Polymers. Nov2025:Part 1, Vol. 368, pN.PAG-N.PAG. 1p. |
| Subjects: | Gum arabic, Drug delivery systems, Treatment effectiveness, Nanoparticles, Adhesives, Pharmaceutical chemistry, Biomaterials, Polysaccharides |
| Abstract: | Gum Arabic (GA), a naturally occurring polysaccharide, has emerged as a promising biomaterial for drug delivery systems (DDS) due to its high water solubility, emulsifying capacity, biocompatibility, and biodegradability. Its structural richness in arabinogalactan facilitates strong interactions with biomolecules, enabling the development of various drug formulations including hydrogels, nanoparticles, liposomes, and emulsions. GA-based DDS have demonstrated significant potential in enhancing the solubility of poorly water-soluble drugs, protecting bioactive compounds from degradation, and enabling sustained and controlled drug release. Moreover, its bioadhesive properties improve drug retention at target sites, thereby augmenting therapeutic efficacy. Recent advances have explored the applications of GA in cancer therapy, antimicrobial treatments, and bioimaging, leveraging its ability to functionalize nanoparticles and conjugate with other polymers. Despite these promising attributes, challenges such as batch-to-batch variability and uncontrolled interactions with formulation components remain critical issues. Addressing these limitations through standardized functionalization strategies and integration with emerging nanotechnologies is essential for optimizing the performance of GA in advanced drug delivery applications. This review systematically discusses the current progress, challenges, and future perspectives of GA-based DDS, highlighting its multifunctional role in pharmaceutical science. [Display omitted] [ABSTRACT FROM AUTHOR] |
| Copyright of Carbohydrate Polymers is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 187721835 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Gum arabic in drug delivery systems: A route-specific overview and functional insights. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Patel%2C+Rutu%22">Patel, Rutu</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Khumkar%2C+Rucha%22">Khumkar, Rucha</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Suvarna%2C+Vasanti%22">Suvarna, Vasanti</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> vasanti.suvarna@bncp.ac.in</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Carbohydrate+Polymers%22">Carbohydrate Polymers</searchLink>. Nov2025:Part 1, Vol. 368, pN.PAG-N.PAG. 1p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Gum+arabic%22">Gum arabic</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+delivery+systems%22">Drug delivery systems</searchLink><br /><searchLink fieldCode="DE" term="%22Treatment+effectiveness%22">Treatment effectiveness</searchLink><br /><searchLink fieldCode="DE" term="%22Nanoparticles%22">Nanoparticles</searchLink><br /><searchLink fieldCode="DE" term="%22Adhesives%22">Adhesives</searchLink><br /><searchLink fieldCode="DE" term="%22Pharmaceutical+chemistry%22">Pharmaceutical chemistry</searchLink><br /><searchLink fieldCode="DE" term="%22Biomaterials%22">Biomaterials</searchLink><br /><searchLink fieldCode="DE" term="%22Polysaccharides%22">Polysaccharides</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Gum Arabic (GA), a naturally occurring polysaccharide, has emerged as a promising biomaterial for drug delivery systems (DDS) due to its high water solubility, emulsifying capacity, biocompatibility, and biodegradability. Its structural richness in arabinogalactan facilitates strong interactions with biomolecules, enabling the development of various drug formulations including hydrogels, nanoparticles, liposomes, and emulsions. GA-based DDS have demonstrated significant potential in enhancing the solubility of poorly water-soluble drugs, protecting bioactive compounds from degradation, and enabling sustained and controlled drug release. Moreover, its bioadhesive properties improve drug retention at target sites, thereby augmenting therapeutic efficacy. Recent advances have explored the applications of GA in cancer therapy, antimicrobial treatments, and bioimaging, leveraging its ability to functionalize nanoparticles and conjugate with other polymers. Despite these promising attributes, challenges such as batch-to-batch variability and uncontrolled interactions with formulation components remain critical issues. Addressing these limitations through standardized functionalization strategies and integration with emerging nanotechnologies is essential for optimizing the performance of GA in advanced drug delivery applications. This review systematically discusses the current progress, challenges, and future perspectives of GA-based DDS, highlighting its multifunctional role in pharmaceutical science. [Display omitted] [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Carbohydrate Polymers is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.carbpol.2025.124139 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 1 StartPage: N.PAG Subjects: – SubjectFull: Gum arabic Type: general – SubjectFull: Drug delivery systems Type: general – SubjectFull: Treatment effectiveness Type: general – SubjectFull: Nanoparticles Type: general – SubjectFull: Adhesives Type: general – SubjectFull: Pharmaceutical chemistry Type: general – SubjectFull: Biomaterials Type: general – SubjectFull: Polysaccharides Type: general Titles: – TitleFull: Gum arabic in drug delivery systems: A route-specific overview and functional insights. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Patel, Rutu – PersonEntity: Name: NameFull: Khumkar, Rucha – PersonEntity: Name: NameFull: Suvarna, Vasanti IsPartOfRelationships: – BibEntity: Dates: – D: 15 M: 11 Text: Nov2025:Part 1 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 01448617 Numbering: – Type: volume Value: 368 Titles: – TitleFull: Carbohydrate Polymers Type: main |
| ResultId | 1 |
