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Cytocompatibility of mesoporous bioactive glasses doped with cerium and loaded with polyphenols.

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Title: Cytocompatibility of mesoporous bioactive glasses doped with cerium and loaded with polyphenols.
Authors: Salvatori, Roberta1 (AUTHOR) roberta.salvatori@unimore.it, Anesi, Alexandre1 (AUTHOR), Cavazzoli, Chiara2 (AUTHOR), Zambon, Alfonso2 (AUTHOR), Lusvardi, Gigliola2 (AUTHOR) gigliola.lusvardi@unimore.it
Source: Journal of the American Ceramic Society. Nov2025, Vol. 108 Issue 11, p1-9. 9p.
Subjects: Cytocompatibility, Polyphenols, Regeneration (Biology), Cerium, Antioxidants, Cell survival, Bioactive glasses, Biomaterials
Abstract: Therapeutic inorganic ions (TIIs) and biomolecules like polyphenols (POLY) can both enhance the properties of mesoporous bioactive glasses (MBGs), which are promising biomaterials for use in hard and soft tissues. In our previous studies, we demonstrated the excellent antioxidant properties of cerium‐doped MBGs containing polyphenols (Ce‐MBGs‐POLY) and their persistent apatite‐forming ability. Therefore, the aim of this study is to evaluate the cytocompatibility of MBGs containing POLY and/or cerium. The cytocompatibility is evaluated using MLO‐Y4 cells, Neutral Red (NR) and the 3‐(4,5‐dimethyl‐2‐thiazolyl)‐2,5‐diphenyl‐2H‐tetrazolium bromide (MTT) assays, and morphological analyses. The NR and MTT results show that MBG‐POLY and Ce‐MBG‐POLY improve cell viability and proliferation compared with MBG, indicating the beneficial effects of both cerium and polyphenols on cell health. Morphological evaluations using optical and electron microscopes confirmed good cell adhesion and proliferation on the surface of all studied MBGs. MBG‐POLY and Ce‐MBG‐POLY possess not only antioxidant properties and apatite‐forming ability but are also cytocompatible; for this reason, these MBGs may be proposed as innovative materials to promote tissue regeneration and repair. [ABSTRACT FROM AUTHOR]
Copyright of Journal of the American Ceramic Society is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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Items – Name: Title
  Label: Title
  Group: Ti
  Data: Cytocompatibility of mesoporous bioactive glasses doped with cerium and loaded with polyphenols.
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  Label: Authors
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  Data: <searchLink fieldCode="AR" term="%22Salvatori%2C+Roberta%22">Salvatori, Roberta</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> roberta.salvatori@unimore.it</i><br /><searchLink fieldCode="AR" term="%22Anesi%2C+Alexandre%22">Anesi, Alexandre</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cavazzoli%2C+Chiara%22">Cavazzoli, Chiara</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zambon%2C+Alfonso%22">Zambon, Alfonso</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lusvardi%2C+Gigliola%22">Lusvardi, Gigliola</searchLink><relatesTo>2</relatesTo> (AUTHOR)<i> gigliola.lusvardi@unimore.it</i>
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+the+American+Ceramic+Society%22">Journal of the American Ceramic Society</searchLink>. Nov2025, Vol. 108 Issue 11, p1-9. 9p.
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  Label: Subjects
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  Data: <searchLink fieldCode="DE" term="%22Cytocompatibility%22">Cytocompatibility</searchLink><br /><searchLink fieldCode="DE" term="%22Polyphenols%22">Polyphenols</searchLink><br /><searchLink fieldCode="DE" term="%22Regeneration+%28Biology%29%22">Regeneration (Biology)</searchLink><br /><searchLink fieldCode="DE" term="%22Cerium%22">Cerium</searchLink><br /><searchLink fieldCode="DE" term="%22Antioxidants%22">Antioxidants</searchLink><br /><searchLink fieldCode="DE" term="%22Cell+survival%22">Cell survival</searchLink><br /><searchLink fieldCode="DE" term="%22Bioactive+glasses%22">Bioactive glasses</searchLink><br /><searchLink fieldCode="DE" term="%22Biomaterials%22">Biomaterials</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Therapeutic inorganic ions (TIIs) and biomolecules like polyphenols (POLY) can both enhance the properties of mesoporous bioactive glasses (MBGs), which are promising biomaterials for use in hard and soft tissues. In our previous studies, we demonstrated the excellent antioxidant properties of cerium‐doped MBGs containing polyphenols (Ce‐MBGs‐POLY) and their persistent apatite‐forming ability. Therefore, the aim of this study is to evaluate the cytocompatibility of MBGs containing POLY and/or cerium. The cytocompatibility is evaluated using MLO‐Y4 cells, Neutral Red (NR) and the 3‐(4,5‐dimethyl‐2‐thiazolyl)‐2,5‐diphenyl‐2H‐tetrazolium bromide (MTT) assays, and morphological analyses. The NR and MTT results show that MBG‐POLY and Ce‐MBG‐POLY improve cell viability and proliferation compared with MBG, indicating the beneficial effects of both cerium and polyphenols on cell health. Morphological evaluations using optical and electron microscopes confirmed good cell adhesion and proliferation on the surface of all studied MBGs. MBG‐POLY and Ce‐MBG‐POLY possess not only antioxidant properties and apatite‐forming ability but are also cytocompatible; for this reason, these MBGs may be proposed as innovative materials to promote tissue regeneration and repair. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of the American Ceramic Society is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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    Identifiers:
      – Type: doi
        Value: 10.1111/jace.20395
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 9
        StartPage: 1
    Subjects:
      – SubjectFull: Cytocompatibility
        Type: general
      – SubjectFull: Polyphenols
        Type: general
      – SubjectFull: Regeneration (Biology)
        Type: general
      – SubjectFull: Cerium
        Type: general
      – SubjectFull: Antioxidants
        Type: general
      – SubjectFull: Cell survival
        Type: general
      – SubjectFull: Bioactive glasses
        Type: general
      – SubjectFull: Biomaterials
        Type: general
    Titles:
      – TitleFull: Cytocompatibility of mesoporous bioactive glasses doped with cerium and loaded with polyphenols.
        Type: main
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          Name:
            NameFull: Salvatori, Roberta
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            NameFull: Anesi, Alexandre
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            NameFull: Cavazzoli, Chiara
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            NameFull: Zambon, Alfonso
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            NameFull: Lusvardi, Gigliola
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            – D: 01
              M: 11
              Text: Nov2025
              Type: published
              Y: 2025
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              Value: 108
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              Value: 11
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