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Non-enhanced MRI flow evaluation using 4D versus 2D phase-contrast in repaired Tetralogy of Fallot adults.

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Title: Non-enhanced MRI flow evaluation using 4D versus 2D phase-contrast in repaired Tetralogy of Fallot adults.
Authors: Champollion, Jean Alfred François1 (AUTHOR) radiologiechampollion@gmail.com, Senage, Thomas2 (AUTHOR), Marteau, Lara1 (AUTHOR), Serfaty, Jean-Michel1 (AUTHOR), Guerin, Patrice2 (AUTHOR), Dacher, Jean-Nicolas3 (AUTHOR), Warin-Fresse, Karine1 (AUTHOR)
Source: European Radiology. Oct2025, Vol. 35 Issue 10, p6313-6322. 10p.
Subjects: Tetralogy of Fallot, Four-dimensional imaging, Pulmonary valve, Phase-contrast microscopy, Cardiac imaging, Quantitative research, Magnetic resonance imaging
Abstract: Objectives: To describe the reliability of quantitative MRI analysis of flows using 4D-PC (Phase Contrast) compared to 2D-PC flow, without contrast agents. Materials and methods: The study was conducted at one centre in a retrospective manner from 2021 to 2023. Eligible patients were adults with repaired Tetralogy of Fallot (rToF) whose follow-up MRI protocol included 4D-PC and 2D-PC, without contrast agent. Assessment involved quantitative measurement of aortic and pulmonary flows on both 4D and 2D. Student's T was used for comparisons of means and Lin's concordance correlation coefficient agreement (CCC). A 2nd observer was hired. Results: Twenty-six patients were included (50% men, median age of 27 [20; 34]). Scanning mean time was 13 min for 4D and 47 min for non-4D part. Systematic underestimation in pulmonary regurgitation fraction (−10 ± 15%, p = 0.02) and backward volume (−13 ± 18 mL, p = 0.02) was found. Agreement on regurgitant fraction was strong for pulmonary (CCC = 0.75 [0.58–0.86], p < 0.001) and aortic (CCC = 0.91 [0.81–0.95], p < 0.001). Inter-observer showed overall strong results. Conclusion: Non-enhanced 4D-PC flow MRI seems to be a reliable method of quantitative flow in rToF patients, but it may underestimate pulmonary regurgitation. Key Points: Question4D-MRI stands out as an innovative tool for evaluating flows in adults with repaired Tetralogy of Fallot during follow-up. Findings4D phase-contrast imaging without the use of contrast agents exhibits robust results and high reproducibility. Clinical relevance4D-MR is presented as an accurate and versatile tool of cardiac exploration that could improve patient comfort. Minimizing brain gadolinium exposure and reducing scanning time are key objectives of non-enhanced 4D-MR. [ABSTRACT FROM AUTHOR]
Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Non-enhanced MRI flow evaluation using 4D versus 2D phase-contrast in repaired Tetralogy of Fallot adults.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Champollion%2C+Jean+Alfred+Fran&#231;ois%22&quot;&gt;Champollion, Jean Alfred Fran&#231;ois&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;i&gt; radiologiechampollion@gmail.com&lt;/i&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Senage%2C+Thomas%22&quot;&gt;Senage, Thomas&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Marteau%2C+Lara%22&quot;&gt;Marteau, Lara&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Serfaty%2C+Jean-Michel%22&quot;&gt;Serfaty, Jean-Michel&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Guerin%2C+Patrice%22&quot;&gt;Guerin, Patrice&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Dacher%2C+Jean-Nicolas%22&quot;&gt;Dacher, Jean-Nicolas&lt;/searchLink&gt;&lt;relatesTo&gt;3&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Warin-Fresse%2C+Karine%22&quot;&gt;Warin-Fresse, Karine&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)
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  Data: Objectives: To describe the reliability of quantitative MRI analysis of flows using 4D-PC (Phase Contrast) compared to 2D-PC flow, without contrast agents. Materials and methods: The study was conducted at one centre in a retrospective manner from 2021 to 2023. Eligible patients were adults with repaired Tetralogy of Fallot (rToF) whose follow-up MRI protocol included 4D-PC and 2D-PC, without contrast agent. Assessment involved quantitative measurement of aortic and pulmonary flows on both 4D and 2D. Student&#39;s T was used for comparisons of means and Lin&#39;s concordance correlation coefficient agreement (CCC). A 2nd observer was hired. Results: Twenty-six patients were included (50% men, median age of 27 [20; 34]). Scanning mean time was 13 min for 4D and 47 min for non-4D part. Systematic underestimation in pulmonary regurgitation fraction (−10 &#177; 15%, p = 0.02) and backward volume (−13 &#177; 18 mL, p = 0.02) was found. Agreement on regurgitant fraction was strong for pulmonary (CCC = 0.75 [0.58–0.86], p &lt; 0.001) and aortic (CCC = 0.91 [0.81–0.95], p &lt; 0.001). Inter-observer showed overall strong results. Conclusion: Non-enhanced 4D-PC flow MRI seems to be a reliable method of quantitative flow in rToF patients, but it may underestimate pulmonary regurgitation. Key Points: Question4D-MRI stands out as an innovative tool for evaluating flows in adults with repaired Tetralogy of Fallot during follow-up. Findings4D phase-contrast imaging without the use of contrast agents exhibits robust results and high reproducibility. Clinical relevance4D-MR is presented as an accurate and versatile tool of cardiac exploration that could improve patient comfort. Minimizing brain gadolinium exposure and reducing scanning time are key objectives of non-enhanced 4D-MR. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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        Value: 10.1007/s00330-025-11542-z
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              Text: Oct2025
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