View in EDS

Unlocking the potential of lipid nanoparticles for enhanced glioma therapy: Recent advancements and future perspectives.

Saved in:
Bibliographic Details
Title: Unlocking the potential of lipid nanoparticles for enhanced glioma therapy: Recent advancements and future perspectives.
Authors: Bera, Shiuli1 (AUTHOR), Ganguly, Shayeri Chatterjee1 (AUTHOR), Manna, Priya1 (AUTHOR), Kundu, Moumita1,2 (AUTHOR) moumitakundu1991@gmail.com
Source: Colloids & Surfaces B: Biointerfaces. Dec2025:Part 2, Vol. 256, pN.PAG-N.PAG. 1p.
Subjects: Gliomas, Liposomes, Blood-brain barrier, Therapeutics, Drug resistance in cancer cells, Drug delivery systems
Abstract: The most prevalent malignant CNS tumor is glioma, which exhibits a poor survival rate due to several limitations in its successful therapy. The existence of the blood-brain barrier, tumor heterogeneity, complex tumor microenvironment, and glioma stem cells are significant challenges in glioma therapy. This review article provides insight into the major hurdles of glioma therapy. The article's primary focus is to explore lipid nanocarriers' potential role in overcoming these glioma therapy hurdles. Various types of lipid nano-systems have been discussed here. Moreover, this article explains the promise of smart lipid nanoparticles in successful glioma therapy. It also reviews the advanced applications of lipid nanocarriers in glioma, including brain-specific drug delivery, overcoming chemoresistance, radioresistance, and immunotherapy resistance, combined therapy with photodynamic therapy and hyperthermia. This article also highlights the current status of the clinical application of lipid nanoparticles in glioma treatment, emphasizing the need for research in this field to achieve improved therapeutic outcomes for glioma patients. [Display omitted] • Glioma therapy possesses limitations such as blood-brain barrier, tumor heterogeneity, and tumor microenvironment. • Lipid nanoparticles or LNPs include liposomes, solid-lipid nanoparticles, nanostructured lipid carriers, etc. • Advanced LNPs like thermo-, pH-, or magnetic field sensitive nanocarriers exhibited promising effects in glioma therapy. • LNPs are excellent candidates for nose-to-brain delivery. • LNPs are employed synergistically with hyperthermia or photodynamic therapy to deal with therapeutic resistance. [ABSTRACT FROM AUTHOR]
Copyright of Colloids & Surfaces B: Biointerfaces is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
FullText Text:
  Availability: 0
Header DbId: egs
DbLabel: Engineering Source
An: 187810546
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Unlocking the potential of lipid nanoparticles for enhanced glioma therapy: Recent advancements and future perspectives.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Bera%2C+Shiuli%22">Bera, Shiuli</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ganguly%2C+Shayeri+Chatterjee%22">Ganguly, Shayeri Chatterjee</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Manna%2C+Priya%22">Manna, Priya</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kundu%2C+Moumita%22">Kundu, Moumita</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> moumitakundu1991@gmail.com</i>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Colloids+%26+Surfaces+B%3A+Biointerfaces%22">Colloids & Surfaces B: Biointerfaces</searchLink>. Dec2025:Part 2, Vol. 256, pN.PAG-N.PAG. 1p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Gliomas%22">Gliomas</searchLink><br /><searchLink fieldCode="DE" term="%22Liposomes%22">Liposomes</searchLink><br /><searchLink fieldCode="DE" term="%22Blood-brain+barrier%22">Blood-brain barrier</searchLink><br /><searchLink fieldCode="DE" term="%22Therapeutics%22">Therapeutics</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+resistance+in+cancer+cells%22">Drug resistance in cancer cells</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+delivery+systems%22">Drug delivery systems</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The most prevalent malignant CNS tumor is glioma, which exhibits a poor survival rate due to several limitations in its successful therapy. The existence of the blood-brain barrier, tumor heterogeneity, complex tumor microenvironment, and glioma stem cells are significant challenges in glioma therapy. This review article provides insight into the major hurdles of glioma therapy. The article's primary focus is to explore lipid nanocarriers' potential role in overcoming these glioma therapy hurdles. Various types of lipid nano-systems have been discussed here. Moreover, this article explains the promise of smart lipid nanoparticles in successful glioma therapy. It also reviews the advanced applications of lipid nanocarriers in glioma, including brain-specific drug delivery, overcoming chemoresistance, radioresistance, and immunotherapy resistance, combined therapy with photodynamic therapy and hyperthermia. This article also highlights the current status of the clinical application of lipid nanoparticles in glioma treatment, emphasizing the need for research in this field to achieve improved therapeutic outcomes for glioma patients. [Display omitted] • Glioma therapy possesses limitations such as blood-brain barrier, tumor heterogeneity, and tumor microenvironment. • Lipid nanoparticles or LNPs include liposomes, solid-lipid nanoparticles, nanostructured lipid carriers, etc. • Advanced LNPs like thermo-, pH-, or magnetic field sensitive nanocarriers exhibited promising effects in glioma therapy. • LNPs are excellent candidates for nose-to-brain delivery. • LNPs are employed synergistically with hyperthermia or photodynamic therapy to deal with therapeutic resistance. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Colloids & Surfaces B: Biointerfaces is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=187810546
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.colsurfb.2025.115053
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 1
        StartPage: N.PAG
    Subjects:
      – SubjectFull: Gliomas
        Type: general
      – SubjectFull: Liposomes
        Type: general
      – SubjectFull: Blood-brain barrier
        Type: general
      – SubjectFull: Therapeutics
        Type: general
      – SubjectFull: Drug resistance in cancer cells
        Type: general
      – SubjectFull: Drug delivery systems
        Type: general
    Titles:
      – TitleFull: Unlocking the potential of lipid nanoparticles for enhanced glioma therapy: Recent advancements and future perspectives.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Bera, Shiuli
      – PersonEntity:
          Name:
            NameFull: Ganguly, Shayeri Chatterjee
      – PersonEntity:
          Name:
            NameFull: Manna, Priya
      – PersonEntity:
          Name:
            NameFull: Kundu, Moumita
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 12
              Text: Dec2025:Part 2
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-print
              Value: 09277765
          Numbering:
            – Type: volume
              Value: 256
          Titles:
            – TitleFull: Colloids & Surfaces B: Biointerfaces
              Type: main
ResultId 1