Unlocking the potential of lipid nanoparticles for enhanced glioma therapy: Recent advancements and future perspectives.
Saved in:
| Title: | Unlocking the potential of lipid nanoparticles for enhanced glioma therapy: Recent advancements and future perspectives. |
|---|---|
| Authors: | Bera, Shiuli1 (AUTHOR), Ganguly, Shayeri Chatterjee1 (AUTHOR), Manna, Priya1 (AUTHOR), Kundu, Moumita1,2 (AUTHOR) moumitakundu1991@gmail.com |
| Source: | Colloids & Surfaces B: Biointerfaces. Dec2025:Part 2, Vol. 256, pN.PAG-N.PAG. 1p. |
| Subjects: | Gliomas, Liposomes, Blood-brain barrier, Therapeutics, Drug resistance in cancer cells, Drug delivery systems |
| Abstract: | The most prevalent malignant CNS tumor is glioma, which exhibits a poor survival rate due to several limitations in its successful therapy. The existence of the blood-brain barrier, tumor heterogeneity, complex tumor microenvironment, and glioma stem cells are significant challenges in glioma therapy. This review article provides insight into the major hurdles of glioma therapy. The article's primary focus is to explore lipid nanocarriers' potential role in overcoming these glioma therapy hurdles. Various types of lipid nano-systems have been discussed here. Moreover, this article explains the promise of smart lipid nanoparticles in successful glioma therapy. It also reviews the advanced applications of lipid nanocarriers in glioma, including brain-specific drug delivery, overcoming chemoresistance, radioresistance, and immunotherapy resistance, combined therapy with photodynamic therapy and hyperthermia. This article also highlights the current status of the clinical application of lipid nanoparticles in glioma treatment, emphasizing the need for research in this field to achieve improved therapeutic outcomes for glioma patients. [Display omitted] • Glioma therapy possesses limitations such as blood-brain barrier, tumor heterogeneity, and tumor microenvironment. • Lipid nanoparticles or LNPs include liposomes, solid-lipid nanoparticles, nanostructured lipid carriers, etc. • Advanced LNPs like thermo-, pH-, or magnetic field sensitive nanocarriers exhibited promising effects in glioma therapy. • LNPs are excellent candidates for nose-to-brain delivery. • LNPs are employed synergistically with hyperthermia or photodynamic therapy to deal with therapeutic resistance. [ABSTRACT FROM AUTHOR] |
| Copyright of Colloids & Surfaces B: Biointerfaces is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
Be the first to leave a comment!
