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Electrospun Fibers of Polyhydroxyalkanoate/Bacterial Cellulose Blends and Their Role in Nerve Tissue Engineering.

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Title: Electrospun Fibers of Polyhydroxyalkanoate/Bacterial Cellulose Blends and Their Role in Nerve Tissue Engineering.
Authors: Asare, Emmanuel1 (AUTHOR) easare1@sheffield.ac.uk, Azimi, Bahareh2 (AUTHOR), Vasili, Elona2 (AUTHOR), Gregory, David A.1,3 (AUTHOR), Raut, Mahendra1 (AUTHOR), Taylor, Caroline S.1 (AUTHOR), Linari, Stefano4 (AUTHOR), Danti, Serena2 (AUTHOR), Roy, Ipsita1,3 (AUTHOR) i.roy@sheffield.ac.uk
Source: Macromolecular Materials & Engineering. Sep2025, Vol. 310 Issue 9, p1-14. 14p.
Subjects: Tissue scaffolds, Cytocompatibility, Cellulose, Polyhydroxyalkanoates, Nanofibers, Cellulose fibers, Thermal properties, Nervous system regeneration
Abstract: Multimaterial blends are crucial for developing scaffolds for tissue engineering. In this study, novel blend electrospun nanofibers are created by combining short‐chain length polyhydroxyalkanoates (SCL‐PHAs), medium‐chain length polyhydroxyalkanoates (MCL‐PHAs), and bacterial cellulose (BC) using the electrospinning technique. The resulting fibrous materials are characterized for their thermal properties, morphology, and cytocompatibility with NG108‐15 neuronal cells. The fabricated blend nanofibers demonstrate good cytocompatibility, as indicated by trends in cell viability and neurite outgrowth in NG108‐15 cells. Importantly, the inclusion of BC in the blend significantly improves the thermal stability of the polymer matrix, as confirmed by thermogravimetric analysis. This study introduces the concept of environmentally friendly and multifunctional materials, highlighting their potential for diverse applications in various scientific disciplines and industries, particularly in the field of nerve tissue engineering. [ABSTRACT FROM AUTHOR]
Copyright of Macromolecular Materials & Engineering is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Electrospun Fibers of Polyhydroxyalkanoate/Bacterial Cellulose Blends and Their Role in Nerve Tissue Engineering.
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  Data: <searchLink fieldCode="AR" term="%22Asare%2C+Emmanuel%22">Asare, Emmanuel</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> easare1@sheffield.ac.uk</i><br /><searchLink fieldCode="AR" term="%22Azimi%2C+Bahareh%22">Azimi, Bahareh</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Vasili%2C+Elona%22">Vasili, Elona</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gregory%2C+David+A%2E%22">Gregory, David A.</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Raut%2C+Mahendra%22">Raut, Mahendra</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Taylor%2C+Caroline+S%2E%22">Taylor, Caroline S.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Linari%2C+Stefano%22">Linari, Stefano</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Danti%2C+Serena%22">Danti, Serena</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Roy%2C+Ipsita%22">Roy, Ipsita</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<i> i.roy@sheffield.ac.uk</i>
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  Data: <searchLink fieldCode="JN" term="%22Macromolecular+Materials+%26+Engineering%22">Macromolecular Materials & Engineering</searchLink>. Sep2025, Vol. 310 Issue 9, p1-14. 14p.
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  Data: <searchLink fieldCode="DE" term="%22Tissue+scaffolds%22">Tissue scaffolds</searchLink><br /><searchLink fieldCode="DE" term="%22Cytocompatibility%22">Cytocompatibility</searchLink><br /><searchLink fieldCode="DE" term="%22Cellulose%22">Cellulose</searchLink><br /><searchLink fieldCode="DE" term="%22Polyhydroxyalkanoates%22">Polyhydroxyalkanoates</searchLink><br /><searchLink fieldCode="DE" term="%22Nanofibers%22">Nanofibers</searchLink><br /><searchLink fieldCode="DE" term="%22Cellulose+fibers%22">Cellulose fibers</searchLink><br /><searchLink fieldCode="DE" term="%22Thermal+properties%22">Thermal properties</searchLink><br /><searchLink fieldCode="DE" term="%22Nervous+system+regeneration%22">Nervous system regeneration</searchLink>
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  Data: Multimaterial blends are crucial for developing scaffolds for tissue engineering. In this study, novel blend electrospun nanofibers are created by combining short‐chain length polyhydroxyalkanoates (SCL‐PHAs), medium‐chain length polyhydroxyalkanoates (MCL‐PHAs), and bacterial cellulose (BC) using the electrospinning technique. The resulting fibrous materials are characterized for their thermal properties, morphology, and cytocompatibility with NG108‐15 neuronal cells. The fabricated blend nanofibers demonstrate good cytocompatibility, as indicated by trends in cell viability and neurite outgrowth in NG108‐15 cells. Importantly, the inclusion of BC in the blend significantly improves the thermal stability of the polymer matrix, as confirmed by thermogravimetric analysis. This study introduces the concept of environmentally friendly and multifunctional materials, highlighting their potential for diverse applications in various scientific disciplines and industries, particularly in the field of nerve tissue engineering. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Macromolecular Materials & Engineering is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1002/mame.202500074
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      – Code: eng
        Text: English
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        PageCount: 14
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    Subjects:
      – SubjectFull: Tissue scaffolds
        Type: general
      – SubjectFull: Cytocompatibility
        Type: general
      – SubjectFull: Cellulose
        Type: general
      – SubjectFull: Polyhydroxyalkanoates
        Type: general
      – SubjectFull: Nanofibers
        Type: general
      – SubjectFull: Cellulose fibers
        Type: general
      – SubjectFull: Thermal properties
        Type: general
      – SubjectFull: Nervous system regeneration
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      – TitleFull: Electrospun Fibers of Polyhydroxyalkanoate/Bacterial Cellulose Blends and Their Role in Nerve Tissue Engineering.
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            NameFull: Asare, Emmanuel
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            – D: 01
              M: 09
              Text: Sep2025
              Type: published
              Y: 2025
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