Interfacial Dynamics in the Fabrication of Various Concave Hydrogel Discs for Enhanced Biosensing.
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| Title: | Interfacial Dynamics in the Fabrication of Various Concave Hydrogel Discs for Enhanced Biosensing. |
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| Authors: | Bakhshayesh, Amin Ghaffarzadeh1 (AUTHOR), Cook, Kara1 (AUTHOR), Li, Huiyan1 (AUTHOR) huiyanli@uoguelph.ca |
| Source: | Polymers (20734360). Sep2025, Vol. 17 Issue 17, p2341. 15p. |
| Subjects: | Interface dynamics, Hydrogels, Alginic acid, Concave surfaces, Calcium chloride, Microscopy, Biosensors, Mass transfer coefficients |
| Abstract: | Hydrogel-based biosensors are commonly used in diagnostic applications. However, their performance remains constrained by slow analyte diffusion within polymer matrices, particularly when larger biomolecules are involved. Concave hydrogel geometries present a promising solution to enhance diffusion rates through increased surface area. However, the interfacial dynamics governing their formation must be studied. In this research, we investigated the interfacial dynamics that influence the formation of concave hydrogel discs fabricated by a simple pipetting method. We characterized the fluid interactions occurring during droplet deposition of alginate and CaCl2 solutions. A three-phase flow model incorporating confocal microscopy validation was employed to simulate time-dependent interfacial behaviors. Concave hydrogel discs fabricated with alginate-first deposition exhibited 83% larger surface area compared to hemispherical counterparts at a CaCl2: alginate volume ratio of one. Increasing the volume ratio further enhanced both surface area and diameter, though this highlighted limitations for microscopy-based detection. According to our results, reaction speed in alginate concave hydrogel discs can be controlled by varying the volume of CaCl2 solution while keeping the volume of alginate solution constant, which changes the surface area while maintaining constant hydrogel volume. [ABSTRACT FROM AUTHOR] |
| Copyright of Polymers (20734360) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
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| Header | DbId: egs DbLabel: Engineering Source An: 187979835 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Interfacial Dynamics in the Fabrication of Various Concave Hydrogel Discs for Enhanced Biosensing. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Bakhshayesh%2C+Amin+Ghaffarzadeh%22">Bakhshayesh, Amin Ghaffarzadeh</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cook%2C+Kara%22">Cook, Kara</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li%2C+Huiyan%22">Li, Huiyan</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> huiyanli@uoguelph.ca</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Polymers+%2820734360%29%22">Polymers (20734360)</searchLink>. Sep2025, Vol. 17 Issue 17, p2341. 15p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Interface+dynamics%22">Interface dynamics</searchLink><br /><searchLink fieldCode="DE" term="%22Hydrogels%22">Hydrogels</searchLink><br /><searchLink fieldCode="DE" term="%22Alginic+acid%22">Alginic acid</searchLink><br /><searchLink fieldCode="DE" term="%22Concave+surfaces%22">Concave surfaces</searchLink><br /><searchLink fieldCode="DE" term="%22Calcium+chloride%22">Calcium chloride</searchLink><br /><searchLink fieldCode="DE" term="%22Microscopy%22">Microscopy</searchLink><br /><searchLink fieldCode="DE" term="%22Biosensors%22">Biosensors</searchLink><br /><searchLink fieldCode="DE" term="%22Mass+transfer+coefficients%22">Mass transfer coefficients</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Hydrogel-based biosensors are commonly used in diagnostic applications. However, their performance remains constrained by slow analyte diffusion within polymer matrices, particularly when larger biomolecules are involved. Concave hydrogel geometries present a promising solution to enhance diffusion rates through increased surface area. However, the interfacial dynamics governing their formation must be studied. In this research, we investigated the interfacial dynamics that influence the formation of concave hydrogel discs fabricated by a simple pipetting method. We characterized the fluid interactions occurring during droplet deposition of alginate and CaCl2 solutions. A three-phase flow model incorporating confocal microscopy validation was employed to simulate time-dependent interfacial behaviors. Concave hydrogel discs fabricated with alginate-first deposition exhibited 83% larger surface area compared to hemispherical counterparts at a CaCl2: alginate volume ratio of one. Increasing the volume ratio further enhanced both surface area and diameter, though this highlighted limitations for microscopy-based detection. According to our results, reaction speed in alginate concave hydrogel discs can be controlled by varying the volume of CaCl2 solution while keeping the volume of alginate solution constant, which changes the surface area while maintaining constant hydrogel volume. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Polymers (20734360) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.3390/polym17172341 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 15 StartPage: 2341 Subjects: – SubjectFull: Interface dynamics Type: general – SubjectFull: Hydrogels Type: general – SubjectFull: Alginic acid Type: general – SubjectFull: Concave surfaces Type: general – SubjectFull: Calcium chloride Type: general – SubjectFull: Microscopy Type: general – SubjectFull: Biosensors Type: general – SubjectFull: Mass transfer coefficients Type: general Titles: – TitleFull: Interfacial Dynamics in the Fabrication of Various Concave Hydrogel Discs for Enhanced Biosensing. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Bakhshayesh, Amin Ghaffarzadeh – PersonEntity: Name: NameFull: Cook, Kara – PersonEntity: Name: NameFull: Li, Huiyan IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 09 Text: Sep2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 20734360 Numbering: – Type: volume Value: 17 – Type: issue Value: 17 Titles: – TitleFull: Polymers (20734360) Type: main |
| ResultId | 1 |
