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Comparative review of human health reference values of the United States.

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Title: Comparative review of human health reference values of the United States.
Authors: Woodall, George M1 (AUTHOR), Kobylewski-Saucier, Sarah E2 (AUTHOR), Shaffer, Rachel M3 (AUTHOR), Luke, April M4 (AUTHOR), Carlson, Laura M1 (AUTHOR)
Source: Toxicological Sciences. Sep2025, Vol. 207 Issue 1, p1-19. 19p.
Subjects: Reference values, Risk assessment, Toxic substance exposure, Public health, Threshold limit values (Industrial toxicology), Environmental exposure
Geographic Terms: United States
Abstract: Human health reference values (HHRVs) developed by US governmental agencies and professional organizations are derived for specific purposes related to their organizational or statutory mandates, and for individual chemicals or substance groups (e.g. manganese compounds). Choosing an appropriate chemical-specific value should be based on the risk assessment need and the specific exposure context, along with a basic understanding of the various types and the intended purposes of each available HHRV. In this overview, HHRVs have been broadly organized into 3 main categories: values for the general public, occupational exposure limits, and emergency response values. The goal of this overview is to equip the reader with a greater understanding of HHRVs, how they are meant to be applied, and key aspects to consider in selecting the most appropriate value. These key aspects include target population (e.g. general public of all ages vs. working-age adults), duration and frequency of exposure, health effect severity, confidence in the data set, use of well-documented and contemporary derivation methods, transparency and documentation of the value derivation, and the thoroughness of the review process. Chemical- and exposure scenario-specific needs should determine which HHRV is most appropriate; however, a most appropriate HHRV may not be available for every chemical and situation. Therefore, we present both considerations and limitations to guide the selection of an alternate HHRV based on suitability for the assessment scenario from among the available chemical-specific values. [ABSTRACT FROM AUTHOR]
Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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  Availability: 0
Header DbId: egs
DbLabel: Engineering Source
An: 188101021
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: <searchLink fieldCode="DE" term="%22Reference+values%22">Reference values</searchLink><br /><searchLink fieldCode="DE" term="%22Risk+assessment%22">Risk assessment</searchLink><br /><searchLink fieldCode="DE" term="%22Toxic+substance+exposure%22">Toxic substance exposure</searchLink><br /><searchLink fieldCode="DE" term="%22Public+health%22">Public health</searchLink><br /><searchLink fieldCode="DE" term="%22Threshold+limit+values+%28Industrial+toxicology%29%22">Threshold limit values (Industrial toxicology)</searchLink><br /><searchLink fieldCode="DE" term="%22Environmental+exposure%22">Environmental exposure</searchLink>
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  Data: Human health reference values (HHRVs) developed by US governmental agencies and professional organizations are derived for specific purposes related to their organizational or statutory mandates, and for individual chemicals or substance groups (e.g. manganese compounds). Choosing an appropriate chemical-specific value should be based on the risk assessment need and the specific exposure context, along with a basic understanding of the various types and the intended purposes of each available HHRV. In this overview, HHRVs have been broadly organized into 3 main categories: values for the general public, occupational exposure limits, and emergency response values. The goal of this overview is to equip the reader with a greater understanding of HHRVs, how they are meant to be applied, and key aspects to consider in selecting the most appropriate value. These key aspects include target population (e.g. general public of all ages vs. working-age adults), duration and frequency of exposure, health effect severity, confidence in the data set, use of well-documented and contemporary derivation methods, transparency and documentation of the value derivation, and the thoroughness of the review process. Chemical- and exposure scenario-specific needs should determine which HHRV is most appropriate; however, a most appropriate HHRV may not be available for every chemical and situation. Therefore, we present both considerations and limitations to guide the selection of an alternate HHRV based on suitability for the assessment scenario from among the available chemical-specific values. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1093/toxsci/kfaf092
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      – Code: eng
        Text: English
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        PageCount: 19
        StartPage: 1
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      – SubjectFull: Reference values
        Type: general
      – SubjectFull: Risk assessment
        Type: general
      – SubjectFull: Toxic substance exposure
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      – SubjectFull: Public health
        Type: general
      – SubjectFull: Threshold limit values (Industrial toxicology)
        Type: general
      – SubjectFull: Environmental exposure
        Type: general
      – SubjectFull: United States
        Type: general
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      – TitleFull: Comparative review of human health reference values of the United States.
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            NameFull: Woodall, George M
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            NameFull: Kobylewski-Saucier, Sarah E
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            NameFull: Shaffer, Rachel M
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            – D: 01
              M: 09
              Text: Sep2025
              Type: published
              Y: 2025
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