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Development and optimization of human deuterium MR spectroscopic imaging at 3 T in the abdomen.

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Title: Development and optimization of human deuterium MR spectroscopic imaging at 3 T in the abdomen.
Authors: McLean, Mary A.1,2 (AUTHOR) mam23@cam.ac.uk, Horvat Menih, Ines1,2 (AUTHOR), Wodtke, Pascal1,2 (AUTHOR), Kaggie, Joshua D.1,2 (AUTHOR), Birchall, Jonathan R.1,2 (AUTHOR), Schulte, Rolf F.3 (AUTHOR), Grimmer, Ashley1,2 (AUTHOR), Latimer, Elizabeth1,2 (AUTHOR), Wylot, Marta1,2 (AUTHOR), Zamora Morales, Maria J.1,2 (AUTHOR), Khan, Alixander S.1,2 (AUTHOR), Wang, Huanjun1 (AUTHOR), Armitage, James2,4 (AUTHOR), Mitchell, Thomas J.2,4,5 (AUTHOR), Stewart, Grant D.2,4,5 (AUTHOR), Gallagher, Ferdia A.1,2 (AUTHOR)
Source: Magnetic Resonance in Medicine. Oct2025, Vol. 94 Issue 4, p1377-1385. 9p.
Subjects: Deuterium, Spectroscopic imaging, Deuterium compounds, Abdomen, Electric coils, Kidney tumors
Abstract: Purpose: To establish and optimize abdominal deuterium MR spectroscopic imaging in conjunction with orally administered 2H‐labeled molecules. Methods: A flexible transmit‐receive surface coil was used to image naturally abundant deuterium signal in phantoms and healthy volunteers and after orally administered 2H2O in a patient with a benign renal tumor (oncocytoma). Results: Water and lipid peaks were fitted with high confidence from both unlocalized spectra and from voxels within the liver, kidney, and spleen on spectroscopic imaging. Artifacts were minimal, despite the high 2H2O concentration in the stomach immediately after ingestion, which can be problematic with the use of a volume coil. Conclusion: We have shown the feasibility of abdominal deuterium MR spectroscopic imaging at 3 T using a flexible surface coil. Water measurements were obtained in healthy volunteers, and images were acquired in a patient with a renal tumor after drinking 2H2O. The limited depth penetration of the surface coil may have advantages in characterizing early uptake of orally administered agents in abdominal organs, despite the high concentrations in the stomach which can pose challenges with other coil combinations. [ABSTRACT FROM AUTHOR]
Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Development and optimization of human deuterium MR spectroscopic imaging at 3 T in the abdomen.
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  Data: <searchLink fieldCode="AR" term="%22McLean%2C+Mary+A%2E%22">McLean, Mary A.</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> mam23@cam.ac.uk</i><br /><searchLink fieldCode="AR" term="%22Horvat+Menih%2C+Ines%22">Horvat Menih, Ines</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wodtke%2C+Pascal%22">Wodtke, Pascal</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kaggie%2C+Joshua+D%2E%22">Kaggie, Joshua D.</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Birchall%2C+Jonathan+R%2E%22">Birchall, Jonathan R.</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Schulte%2C+Rolf+F%2E%22">Schulte, Rolf F.</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Grimmer%2C+Ashley%22">Grimmer, Ashley</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Latimer%2C+Elizabeth%22">Latimer, Elizabeth</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wylot%2C+Marta%22">Wylot, Marta</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zamora+Morales%2C+Maria+J%2E%22">Zamora Morales, Maria J.</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Khan%2C+Alixander+S%2E%22">Khan, Alixander S.</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wang%2C+Huanjun%22">Wang, Huanjun</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Armitage%2C+James%22">Armitage, James</searchLink><relatesTo>2,4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mitchell%2C+Thomas+J%2E%22">Mitchell, Thomas J.</searchLink><relatesTo>2,4,5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Stewart%2C+Grant+D%2E%22">Stewart, Grant D.</searchLink><relatesTo>2,4,5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gallagher%2C+Ferdia+A%2E%22">Gallagher, Ferdia A.</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Magnetic+Resonance+in+Medicine%22">Magnetic Resonance in Medicine</searchLink>. Oct2025, Vol. 94 Issue 4, p1377-1385. 9p.
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  Data: <searchLink fieldCode="DE" term="%22Deuterium%22">Deuterium</searchLink><br /><searchLink fieldCode="DE" term="%22Spectroscopic+imaging%22">Spectroscopic imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Deuterium+compounds%22">Deuterium compounds</searchLink><br /><searchLink fieldCode="DE" term="%22Abdomen%22">Abdomen</searchLink><br /><searchLink fieldCode="DE" term="%22Electric+coils%22">Electric coils</searchLink><br /><searchLink fieldCode="DE" term="%22Kidney+tumors%22">Kidney tumors</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Purpose: To establish and optimize abdominal deuterium MR spectroscopic imaging in conjunction with orally administered 2H‐labeled molecules. Methods: A flexible transmit‐receive surface coil was used to image naturally abundant deuterium signal in phantoms and healthy volunteers and after orally administered 2H2O in a patient with a benign renal tumor (oncocytoma). Results: Water and lipid peaks were fitted with high confidence from both unlocalized spectra and from voxels within the liver, kidney, and spleen on spectroscopic imaging. Artifacts were minimal, despite the high 2H2O concentration in the stomach immediately after ingestion, which can be problematic with the use of a volume coil. Conclusion: We have shown the feasibility of abdominal deuterium MR spectroscopic imaging at 3 T using a flexible surface coil. Water measurements were obtained in healthy volunteers, and images were acquired in a patient with a renal tumor after drinking 2H2O. The limited depth penetration of the surface coil may have advantages in characterizing early uptake of orally administered agents in abdominal organs, despite the high concentrations in the stomach which can pose challenges with other coil combinations. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1002/mrm.30556
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        Text: English
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        PageCount: 9
        StartPage: 1377
    Subjects:
      – SubjectFull: Deuterium
        Type: general
      – SubjectFull: Spectroscopic imaging
        Type: general
      – SubjectFull: Deuterium compounds
        Type: general
      – SubjectFull: Abdomen
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      – SubjectFull: Electric coils
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      – SubjectFull: Kidney tumors
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