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Simultaneous T1, T2, and T1ρ mapping of the myocardium using cardiac MR fingerprinting with a deep image prior reconstruction.

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Title: Simultaneous T1, T2, and T1ρ mapping of the myocardium using cardiac MR fingerprinting with a deep image prior reconstruction.
Authors: Kaplan, Sydney1,2 (AUTHOR) kaplansn@umich.edu, da Cruz, Gastao Lima2 (AUTHOR), Madamanchi, Chaitanya2,3 (AUTHOR), Murthy, Venkatesh L.2,4 (AUTHOR), Swanson, Scott2 (AUTHOR), Hamilton, Jesse1,2 (AUTHOR), Seiberlich, Nicole1,2 (AUTHOR)
Source: Magnetic Resonance in Medicine. Oct2025, Vol. 94 Issue 4, p1500-1513. 14p.
Subjects: Cardiac magnetic resonance imaging, Myocardium, Gadolinium, Cardiomyopathies, Magnetic resonance imaging, Image reconstruction
Abstract: Purpose: To develop a cardiac MR fingerprinting (cMRF) approach using deep image prior reconstruction (DIP) to simultaneously map T1, T2, and T1ρ, and assess T1ρ in healthy subjects and patients with areas of enhancement on late gadolinium enhancement. Methods: A 2D electrocardiogram‐triggered cMRF sequence was developed to measure T1, T2, and T1ρ simultaneously. DIP reconstruction was evaluated for noise and artifact reduction compared to a low‐rank reconstruction. Measurements were assessed in simulation and phantom for accuracy. T1ρ‐cMRF maps were generated in 10 healthy subjects and six patients under evaluation for cardiomyopathy, myocarditis, and amyloidosis receiving gadolinium‐based contrast agent–enhanced CMR at 1.5 T. Results: T1ρ‐cMRF maps showed excellent agreement with ground truth (RMS error = 3.0% ± 5.3%) and conventional methods (R2 = 0.99) in simulations and phantom experiments. Measured values in healthy subjects were consistent with literature (T1 = 1051 ± 63 ms, T2 = 41.4 ± 3.3 ms, and T1ρ = 45.5 ± 2.4 ms). DIP reconstruction reduced noise, indicated by lower coefficient of variation (Δ = 4.7), compared to low‐rank reconstruction. Mean differences of 10.2 ms (p = 0.02) in T1ρ and 6.9 ms in T2 maps were observed between areas of enhancement on late gadolinium enhancement and normal‐appearing myocardium in patients. Within individual patients, significant differences (p < 0.01) in T1, T2, and T1ρ were observed between American Heart Association segments with and without contrast enhancement. Conclusion: The proposed T1ρ‐cMRF sequence using DIP reconstruction enables simultaneous quantification of T1, T2, and T1ρ with decreased coefficient of variation compared to low‐rank reconstruction. Simulation and phantom studies show good agreement with references. In vivo measurements were made in healthy subjects, and areas of contrast enhancement in patients showed elevated T2 and T1ρ relative to remote myocardium. [ABSTRACT FROM AUTHOR]
Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Simultaneous T&lt;subscript&gt;1&lt;/subscript&gt;, T&lt;subscript&gt;2&lt;/subscript&gt;, and T&lt;subscript&gt;1ρ&lt;/subscript&gt; mapping of the myocardium using cardiac MR fingerprinting with a deep image prior reconstruction.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Kaplan%2C+Sydney%22&quot;&gt;Kaplan, Sydney&lt;/searchLink&gt;&lt;relatesTo&gt;1,2&lt;/relatesTo&gt; (AUTHOR)&lt;i&gt; kaplansn@umich.edu&lt;/i&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22da+Cruz%2C+Gastao+Lima%22&quot;&gt;da Cruz, Gastao Lima&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Madamanchi%2C+Chaitanya%22&quot;&gt;Madamanchi, Chaitanya&lt;/searchLink&gt;&lt;relatesTo&gt;2,3&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Murthy%2C+Venkatesh+L%2E%22&quot;&gt;Murthy, Venkatesh L.&lt;/searchLink&gt;&lt;relatesTo&gt;2,4&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Swanson%2C+Scott%22&quot;&gt;Swanson, Scott&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Hamilton%2C+Jesse%22&quot;&gt;Hamilton, Jesse&lt;/searchLink&gt;&lt;relatesTo&gt;1,2&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Seiberlich%2C+Nicole%22&quot;&gt;Seiberlich, Nicole&lt;/searchLink&gt;&lt;relatesTo&gt;1,2&lt;/relatesTo&gt; (AUTHOR)
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Magnetic+Resonance+in+Medicine%22&quot;&gt;Magnetic Resonance in Medicine&lt;/searchLink&gt;. Oct2025, Vol. 94 Issue 4, p1500-1513. 14p.
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Cardiac+magnetic+resonance+imaging%22&quot;&gt;Cardiac magnetic resonance imaging&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Myocardium%22&quot;&gt;Myocardium&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Gadolinium%22&quot;&gt;Gadolinium&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Cardiomyopathies%22&quot;&gt;Cardiomyopathies&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Magnetic+resonance+imaging%22&quot;&gt;Magnetic resonance imaging&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Image+reconstruction%22&quot;&gt;Image reconstruction&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Purpose: To develop a cardiac MR fingerprinting (cMRF) approach using deep image prior reconstruction (DIP) to simultaneously map T1, T2, and T1ρ, and assess T1ρ in healthy subjects and patients with areas of enhancement on late gadolinium enhancement. Methods: A 2D electrocardiogram‐triggered cMRF sequence was developed to measure T1, T2, and T1ρ simultaneously. DIP reconstruction was evaluated for noise and artifact reduction compared to a low‐rank reconstruction. Measurements were assessed in simulation and phantom for accuracy. T1ρ‐cMRF maps were generated in 10 healthy subjects and six patients under evaluation for cardiomyopathy, myocarditis, and amyloidosis receiving gadolinium‐based contrast agent–enhanced CMR at 1.5 T. Results: T1ρ‐cMRF maps showed excellent agreement with ground truth (RMS error = 3.0% &#177; 5.3%) and conventional methods (R2 = 0.99) in simulations and phantom experiments. Measured values in healthy subjects were consistent with literature (T1 = 1051 &#177; 63 ms, T2 = 41.4 &#177; 3.3 ms, and T1ρ = 45.5 &#177; 2.4 ms). DIP reconstruction reduced noise, indicated by lower coefficient of variation (Δ = 4.7), compared to low‐rank reconstruction. Mean differences of 10.2 ms (p = 0.02) in T1ρ and 6.9 ms in T2 maps were observed between areas of enhancement on late gadolinium enhancement and normal‐appearing myocardium in patients. Within individual patients, significant differences (p &lt; 0.01) in T1, T2, and T1ρ were observed between American Heart Association segments with and without contrast enhancement. Conclusion: The proposed T1ρ‐cMRF sequence using DIP reconstruction enables simultaneous quantification of T1, T2, and T1ρ with decreased coefficient of variation compared to low‐rank reconstruction. Simulation and phantom studies show good agreement with references. In vivo measurements were made in healthy subjects, and areas of contrast enhancement in patients showed elevated T2 and T1ρ relative to remote myocardium. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: &lt;i&gt;Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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        Value: 10.1002/mrm.30580
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        Text: English
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      – SubjectFull: Cardiac magnetic resonance imaging
        Type: general
      – SubjectFull: Myocardium
        Type: general
      – SubjectFull: Gadolinium
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      – SubjectFull: Cardiomyopathies
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      – SubjectFull: Magnetic resonance imaging
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      – SubjectFull: Image reconstruction
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      – TitleFull: Simultaneous T1, T2, and T1ρ mapping of the myocardium using cardiac MR fingerprinting with a deep image prior reconstruction.
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              M: 10
              Text: Oct2025
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              Y: 2025
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