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Radiosensitization by Docetaxel Prodrug-Loaded Lipid Nanoparticles in Pancreatic Cancer Xenografts.

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Title: Radiosensitization by Docetaxel Prodrug-Loaded Lipid Nanoparticles in Pancreatic Cancer Xenografts.
Authors: Alhussan, Abdulaziz1 (AUTHOR) ze.alhussan@ubc.ca, Jackson, Nolan2 (AUTHOR), Dos Santos, Nancy3 (AUTHOR), Chen, Sam4 (AUTHOR), Tam, Yuen Yi C.4,5 (AUTHOR), Chithrani, Devika B.2,5,6,7 (AUTHOR)
Source: Nanomaterials (2079-4991). Oct2025, Vol. 15 Issue 19, p1521. 11p.
Subjects: Pancreatic cancer, Radiotherapy, Radiation-sensitizing agents, Cancer treatment, Xenografts, Nanocarriers
Abstract: Cancer treatments are limited by poor tumor specificity and toxicity. We tested a radiosensitizing approach using PEG/RGD-functionalized gold nanoparticles (GNPs), a lipid-nanoparticle–encapsulated docetaxel prodrug (LNPDTX–P), and external-beam radiotherapy (RT). In MIA PaCa-2 xenografts, intravenous GNPs (2 mg/kg) and LNPDTX–P (6 mg/kg) were given before 5 Gy RT. Both LNPDTX–P + RT and GNPs + LNPDTX–P + RT reduced tumor volume by ~40% and significantly prolonged survival versus RT alone (p < 0.001). Adding GNPs did not enhance efficacy, indicating LNPDTX–P was the main driver under this regimen. These results demonstrate nanocarrier-enabled radiosensitization in vivo and support further studies toward clinical translation. [ABSTRACT FROM AUTHOR]
Copyright of Nanomaterials (2079-4991) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Label: Title
  Group: Ti
  Data: Radiosensitization by Docetaxel Prodrug-Loaded Lipid Nanoparticles in Pancreatic Cancer Xenografts.
– Name: Author
  Label: Authors
  Group: Au
  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Alhussan%2C+Abdulaziz%22&quot;&gt;Alhussan, Abdulaziz&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;i&gt; ze.alhussan@ubc.ca&lt;/i&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Jackson%2C+Nolan%22&quot;&gt;Jackson, Nolan&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Dos+Santos%2C+Nancy%22&quot;&gt;Dos Santos, Nancy&lt;/searchLink&gt;&lt;relatesTo&gt;3&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Chen%2C+Sam%22&quot;&gt;Chen, Sam&lt;/searchLink&gt;&lt;relatesTo&gt;4&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Tam%2C+Yuen+Yi+C%2E%22&quot;&gt;Tam, Yuen Yi C.&lt;/searchLink&gt;&lt;relatesTo&gt;4,5&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Chithrani%2C+Devika+B%2E%22&quot;&gt;Chithrani, Devika B.&lt;/searchLink&gt;&lt;relatesTo&gt;2,5,6,7&lt;/relatesTo&gt; (AUTHOR)
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Nanomaterials+%282079-4991%29%22&quot;&gt;Nanomaterials (2079-4991)&lt;/searchLink&gt;. Oct2025, Vol. 15 Issue 19, p1521. 11p.
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Pancreatic+cancer%22&quot;&gt;Pancreatic cancer&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Radiotherapy%22&quot;&gt;Radiotherapy&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Radiation-sensitizing+agents%22&quot;&gt;Radiation-sensitizing agents&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Cancer+treatment%22&quot;&gt;Cancer treatment&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Xenografts%22&quot;&gt;Xenografts&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Nanocarriers%22&quot;&gt;Nanocarriers&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Cancer treatments are limited by poor tumor specificity and toxicity. We tested a radiosensitizing approach using PEG/RGD-functionalized gold nanoparticles (GNPs), a lipid-nanoparticle–encapsulated docetaxel prodrug (LNPDTX–P), and external-beam radiotherapy (RT). In MIA PaCa-2 xenografts, intravenous GNPs (2 mg/kg) and LNPDTX–P (6 mg/kg) were given before 5 Gy RT. Both LNPDTX–P + RT and GNPs + LNPDTX–P + RT reduced tumor volume by ~40% and significantly prolonged survival versus RT alone (p &lt; 0.001). Adding GNPs did not enhance efficacy, indicating LNPDTX–P was the main driver under this regimen. These results demonstrate nanocarrier-enabled radiosensitization in vivo and support further studies toward clinical translation. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: &lt;i&gt;Copyright of Nanomaterials (2079-4991) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.3390/nano15191521
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 11
        StartPage: 1521
    Subjects:
      – SubjectFull: Pancreatic cancer
        Type: general
      – SubjectFull: Radiotherapy
        Type: general
      – SubjectFull: Radiation-sensitizing agents
        Type: general
      – SubjectFull: Cancer treatment
        Type: general
      – SubjectFull: Xenografts
        Type: general
      – SubjectFull: Nanocarriers
        Type: general
    Titles:
      – TitleFull: Radiosensitization by Docetaxel Prodrug-Loaded Lipid Nanoparticles in Pancreatic Cancer Xenografts.
        Type: main
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          Name:
            NameFull: Alhussan, Abdulaziz
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            NameFull: Jackson, Nolan
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            NameFull: Dos Santos, Nancy
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            NameFull: Chen, Sam
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            NameFull: Tam, Yuen Yi C.
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            – D: 01
              M: 10
              Text: Oct2025
              Type: published
              Y: 2025
          Identifiers:
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              Value: 20794991
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              Value: 15
            – Type: issue
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            – TitleFull: Nanomaterials (2079-4991)
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