Radiosensitization by Docetaxel Prodrug-Loaded Lipid Nanoparticles in Pancreatic Cancer Xenografts.
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| Title: | Radiosensitization by Docetaxel Prodrug-Loaded Lipid Nanoparticles in Pancreatic Cancer Xenografts. |
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| Authors: | Alhussan, Abdulaziz1 (AUTHOR) ze.alhussan@ubc.ca, Jackson, Nolan2 (AUTHOR), Dos Santos, Nancy3 (AUTHOR), Chen, Sam4 (AUTHOR), Tam, Yuen Yi C.4,5 (AUTHOR), Chithrani, Devika B.2,5,6,7 (AUTHOR) |
| Source: | Nanomaterials (2079-4991). Oct2025, Vol. 15 Issue 19, p1521. 11p. |
| Subjects: | Pancreatic cancer, Radiotherapy, Radiation-sensitizing agents, Cancer treatment, Xenografts, Nanocarriers |
| Abstract: | Cancer treatments are limited by poor tumor specificity and toxicity. We tested a radiosensitizing approach using PEG/RGD-functionalized gold nanoparticles (GNPs), a lipid-nanoparticle–encapsulated docetaxel prodrug (LNPDTX–P), and external-beam radiotherapy (RT). In MIA PaCa-2 xenografts, intravenous GNPs (2 mg/kg) and LNPDTX–P (6 mg/kg) were given before 5 Gy RT. Both LNPDTX–P + RT and GNPs + LNPDTX–P + RT reduced tumor volume by ~40% and significantly prolonged survival versus RT alone (p < 0.001). Adding GNPs did not enhance efficacy, indicating LNPDTX–P was the main driver under this regimen. These results demonstrate nanocarrier-enabled radiosensitization in vivo and support further studies toward clinical translation. [ABSTRACT FROM AUTHOR] |
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| Database: | Engineering Source |
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