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Effects of nanoparticle physicochemical properties on macrophage polarization.

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Title: Effects of nanoparticle physicochemical properties on macrophage polarization.
Authors: Lin, Haochen1,2 (AUTHOR), Li, Zheng1,2 (AUTHOR), Zelepukin, Ivan V.3,4 (AUTHOR), Deyev, Sergey M.4,5,6 (AUTHOR), Yang, Xiangliang1,2,7,8,9 (AUTHOR), Li, Zifu1,2,7,8,9 (AUTHOR) zifuli@hust.edu.cn
Source: Journal of Controlled Release. Nov2025, Vol. 387, pN.PAG-N.PAG. 1p.
Subjects: Nanoparticles, Macrophages, Tumor microenvironment, Macrophage activation, Immunoregulation, Immunotherapy, Chemical properties
Abstract: Tumor-associated macrophages (TAMs) are crucial in regulating tumor immune microenvironment (TIME), tumor development and tumor therapy. Nanoparticles, as traditional tumor targeting drug delivery systems, of which the intrinsic immunomodulatory potential has been gradually explored by modulating physicochemical properties. This review systematically summarizes advancements in polarizing macrophages by regulating physicochemical properties of nanoparticles including size, morphology, surface properties, stiffness, and other factors. Furthermore, the polarization mechanisms are expounded via biochemical and mechanical signaling pathways. Size of nanoparticles affects macrophage polarization through lysosomal stress and membrane interaction; morphology of nanoparticles impacts macrophage polarization through inducing membrane curvature or modulating cellular metabolism; surface properties of nanoparticles effects macrophage polarization through enhancing nanoparticle binding ability to cell membrane; stiffness of nanoparticles polarize macrophages through activating mechanosensitive ion channels and inducing deformation of membrane; other properties of nanoparticles effects macrophage polarization via glycolysis, oxidative phosphorylation, etc. These outcomes contribute to the optimization of nanomedicine physicochemical properties for tumor immunotherapy by regulating polarization of TAMs and reshaping the immunosuppressive TIME, thereby driving the development of precision immuno-oncology for various malignancies. [Display omitted] • The mechanism of nanoparticle properties on macrophage polarization was elaborated. • The crosstalk between biochemical and mechanical signaling was expounded. • Clinical translational opportunities and challenges of nanoparticle properties on cancer immunotherapy were prospected. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Controlled Release is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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Header DbId: egs
DbLabel: Engineering Source
An: 188750531
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Effects of nanoparticle physicochemical properties on macrophage polarization.
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  Data: <searchLink fieldCode="AR" term="%22Lin%2C+Haochen%22">Lin, Haochen</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li%2C+Zheng%22">Li, Zheng</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zelepukin%2C+Ivan+V%2E%22">Zelepukin, Ivan V.</searchLink><relatesTo>3,4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Deyev%2C+Sergey+M%2E%22">Deyev, Sergey M.</searchLink><relatesTo>4,5,6</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yang%2C+Xiangliang%22">Yang, Xiangliang</searchLink><relatesTo>1,2,7,8,9</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li%2C+Zifu%22">Li, Zifu</searchLink><relatesTo>1,2,7,8,9</relatesTo> (AUTHOR)<i> zifuli@hust.edu.cn</i>
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Controlled+Release%22">Journal of Controlled Release</searchLink>. Nov2025, Vol. 387, pN.PAG-N.PAG. 1p.
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  Data: <searchLink fieldCode="DE" term="%22Nanoparticles%22">Nanoparticles</searchLink><br /><searchLink fieldCode="DE" term="%22Macrophages%22">Macrophages</searchLink><br /><searchLink fieldCode="DE" term="%22Tumor+microenvironment%22">Tumor microenvironment</searchLink><br /><searchLink fieldCode="DE" term="%22Macrophage+activation%22">Macrophage activation</searchLink><br /><searchLink fieldCode="DE" term="%22Immunoregulation%22">Immunoregulation</searchLink><br /><searchLink fieldCode="DE" term="%22Immunotherapy%22">Immunotherapy</searchLink><br /><searchLink fieldCode="DE" term="%22Chemical+properties%22">Chemical properties</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Tumor-associated macrophages (TAMs) are crucial in regulating tumor immune microenvironment (TIME), tumor development and tumor therapy. Nanoparticles, as traditional tumor targeting drug delivery systems, of which the intrinsic immunomodulatory potential has been gradually explored by modulating physicochemical properties. This review systematically summarizes advancements in polarizing macrophages by regulating physicochemical properties of nanoparticles including size, morphology, surface properties, stiffness, and other factors. Furthermore, the polarization mechanisms are expounded via biochemical and mechanical signaling pathways. Size of nanoparticles affects macrophage polarization through lysosomal stress and membrane interaction; morphology of nanoparticles impacts macrophage polarization through inducing membrane curvature or modulating cellular metabolism; surface properties of nanoparticles effects macrophage polarization through enhancing nanoparticle binding ability to cell membrane; stiffness of nanoparticles polarize macrophages through activating mechanosensitive ion channels and inducing deformation of membrane; other properties of nanoparticles effects macrophage polarization via glycolysis, oxidative phosphorylation, etc. These outcomes contribute to the optimization of nanomedicine physicochemical properties for tumor immunotherapy by regulating polarization of TAMs and reshaping the immunosuppressive TIME, thereby driving the development of precision immuno-oncology for various malignancies. [Display omitted] • The mechanism of nanoparticle properties on macrophage polarization was elaborated. • The crosstalk between biochemical and mechanical signaling was expounded. • Clinical translational opportunities and challenges of nanoparticle properties on cancer immunotherapy were prospected. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Controlled Release is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.jconrel.2025.114215
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      – Code: eng
        Text: English
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        PageCount: 1
        StartPage: N.PAG
    Subjects:
      – SubjectFull: Nanoparticles
        Type: general
      – SubjectFull: Macrophages
        Type: general
      – SubjectFull: Tumor microenvironment
        Type: general
      – SubjectFull: Macrophage activation
        Type: general
      – SubjectFull: Immunoregulation
        Type: general
      – SubjectFull: Immunotherapy
        Type: general
      – SubjectFull: Chemical properties
        Type: general
    Titles:
      – TitleFull: Effects of nanoparticle physicochemical properties on macrophage polarization.
        Type: main
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          Name:
            NameFull: Lin, Haochen
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            NameFull: Li, Zheng
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            NameFull: Zelepukin, Ivan V.
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            NameFull: Deyev, Sergey M.
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            NameFull: Yang, Xiangliang
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            NameFull: Li, Zifu
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              M: 11
              Text: Nov2025
              Type: published
              Y: 2025
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              Value: 387
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            – TitleFull: Journal of Controlled Release
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