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Picolinic crystal receptor for multiple Al(III) ions sensing demonstrated through test strip, TLC and Live Cell imaging studies.

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Title: Picolinic crystal receptor for multiple Al(III) ions sensing demonstrated through test strip, TLC and Live Cell imaging studies.
Authors: Chethanakumar1 (AUTHOR), Gudasi, Kalagouda B.1 (AUTHOR) drkbgudasi@kud.ac.in, Vadavi, Ramesh S.1 (AUTHOR) rsvadavi@gmail.com, Nethaji, Munirathinam2 (AUTHOR), Patil, Mallikarjun K.3 (AUTHOR), Kumbar, Vijay M.4 (AUTHOR), Inamdar, Sanjeev R.3 (AUTHOR)
Source: Journal of Molecular Structure. Jan2026:Part 1, Vol. 1349, pN.PAG-N.PAG. 1p.
Subjects: Cell imaging, Fluorescent probes, Thin layer chromatography, Detection algorithms, Imaging systems in biology, Metal ions
Abstract: • We have synthesized, developed a crystal structure and characterized of an asymmetric novel receptor (HSH) for the recognition of Al3+ ions. • The sensing ability of receptor towards Al3+ was successively investigated in aqueous DMF. • The experimental findings were well supported by computational studies. • The obtained nM detection limit and 106 M-1 association constant (K a) values are comparable to reported molecules for Al3+. • The receptor was employed in bio-imaging studies for the recognition of Al3+ in HeLa cells. • Also, the receptor was explored in sensing applications through inexpensive test strips and TLC strips for the recognition of Al3+. Metal ions are vital for living and environmental system. Consequently, their detection and monitoring has been considered great significance by the chemists. Scientists are developing new approaches to recognize these cations. It was successfully demonstrated that fluorescent sensors developed on organic structural framework are effective in detecting all kinds of metal ions and offer a number of benefits, including inexpensiveness, simple synthesis and high sensitivity. In present work, a novel and versatile Schiff base chemosensor 6-(2-((E)-2-hydroxybenzylidene)hydrazine-1-carbonyl)- N -(2-(2-((E)-hydroxybenzylidene)hydrazine-1-carbonyl)phenyl)picolinamide (HSH) was synthesized for quick recognition of Al3+ ions through fluorescence turn-on response at λ max. 473 nm in DMF:H 2 O (1:1). The HSH exhibited high fluorescence property by inhibiting ESIPT process, -C=N- isomerization and enhanced ICT character upon coordinated with Al3+ ions. The stoichiometric ratio (1:2) of the HSH towards Al3+ ions was confirmed by ESI-MS and Job's plot analysis. The obtained detection limit and binding constant value for HSH were found to be 11.93 nM and 8.69 × 106 M−1 respectively. The HSH was utilized for bio-imaging application in HeLa cells. In addition, the sensing properties of HSH were studied on economical test along with TLC kits for the recognition of Al3+ ions. The findings of the present investigation suggest that the HSH could be serve as potent chemosensor for Al3+ ions. [Display omitted] [ABSTRACT FROM AUTHOR]
Copyright of Journal of Molecular Structure is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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Header DbId: egs
DbLabel: Engineering Source
An: 188829728
AccessLevel: 6
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PubTypeId: academicJournal
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  Label: Title
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  Data: Picolinic crystal receptor for multiple Al(III) ions sensing demonstrated through test strip, TLC and Live Cell imaging studies.
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  Data: <searchLink fieldCode="AR" term="%22Chethanakumar%22">Chethanakumar</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gudasi%2C+Kalagouda+B%2E%22">Gudasi, Kalagouda B.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> drkbgudasi@kud.ac.in</i><br /><searchLink fieldCode="AR" term="%22Vadavi%2C+Ramesh+S%2E%22">Vadavi, Ramesh S.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> rsvadavi@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Nethaji%2C+Munirathinam%22">Nethaji, Munirathinam</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Patil%2C+Mallikarjun+K%2E%22">Patil, Mallikarjun K.</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kumbar%2C+Vijay+M%2E%22">Kumbar, Vijay M.</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Inamdar%2C+Sanjeev+R%2E%22">Inamdar, Sanjeev R.</searchLink><relatesTo>3</relatesTo> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Molecular+Structure%22">Journal of Molecular Structure</searchLink>. Jan2026:Part 1, Vol. 1349, pN.PAG-N.PAG. 1p.
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  Data: <searchLink fieldCode="DE" term="%22Cell+imaging%22">Cell imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Fluorescent+probes%22">Fluorescent probes</searchLink><br /><searchLink fieldCode="DE" term="%22Thin+layer+chromatography%22">Thin layer chromatography</searchLink><br /><searchLink fieldCode="DE" term="%22Detection+algorithms%22">Detection algorithms</searchLink><br /><searchLink fieldCode="DE" term="%22Imaging+systems+in+biology%22">Imaging systems in biology</searchLink><br /><searchLink fieldCode="DE" term="%22Metal+ions%22">Metal ions</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: • We have synthesized, developed a crystal structure and characterized of an asymmetric novel receptor (HSH) for the recognition of Al3+ ions. • The sensing ability of receptor towards Al3+ was successively investigated in aqueous DMF. • The experimental findings were well supported by computational studies. • The obtained nM detection limit and 106 M-1 association constant (K a) values are comparable to reported molecules for Al3+. • The receptor was employed in bio-imaging studies for the recognition of Al3+ in HeLa cells. • Also, the receptor was explored in sensing applications through inexpensive test strips and TLC strips for the recognition of Al3+. Metal ions are vital for living and environmental system. Consequently, their detection and monitoring has been considered great significance by the chemists. Scientists are developing new approaches to recognize these cations. It was successfully demonstrated that fluorescent sensors developed on organic structural framework are effective in detecting all kinds of metal ions and offer a number of benefits, including inexpensiveness, simple synthesis and high sensitivity. In present work, a novel and versatile Schiff base chemosensor 6-(2-((E)-2-hydroxybenzylidene)hydrazine-1-carbonyl)- N -(2-(2-((E)-hydroxybenzylidene)hydrazine-1-carbonyl)phenyl)picolinamide (HSH) was synthesized for quick recognition of Al3+ ions through fluorescence turn-on response at λ max. 473 nm in DMF:H 2 O (1:1). The HSH exhibited high fluorescence property by inhibiting ESIPT process, -C=N- isomerization and enhanced ICT character upon coordinated with Al3+ ions. The stoichiometric ratio (1:2) of the HSH towards Al3+ ions was confirmed by ESI-MS and Job's plot analysis. The obtained detection limit and binding constant value for HSH were found to be 11.93 nM and 8.69 × 106 M−1 respectively. The HSH was utilized for bio-imaging application in HeLa cells. In addition, the sensing properties of HSH were studied on economical test along with TLC kits for the recognition of Al3+ ions. The findings of the present investigation suggest that the HSH could be serve as potent chemosensor for Al3+ ions. [Display omitted] [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Molecular Structure is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.molstruc.2025.143724
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 1
        StartPage: N.PAG
    Subjects:
      – SubjectFull: Cell imaging
        Type: general
      – SubjectFull: Fluorescent probes
        Type: general
      – SubjectFull: Thin layer chromatography
        Type: general
      – SubjectFull: Detection algorithms
        Type: general
      – SubjectFull: Imaging systems in biology
        Type: general
      – SubjectFull: Metal ions
        Type: general
    Titles:
      – TitleFull: Picolinic crystal receptor for multiple Al(III) ions sensing demonstrated through test strip, TLC and Live Cell imaging studies.
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            NameFull: Chethanakumar
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            NameFull: Gudasi, Kalagouda B.
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            NameFull: Vadavi, Ramesh S.
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            NameFull: Nethaji, Munirathinam
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            NameFull: Patil, Mallikarjun K.
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            NameFull: Kumbar, Vijay M.
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            NameFull: Inamdar, Sanjeev R.
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          Dates:
            – D: 05
              M: 01
              Text: Jan2026:Part 1
              Type: published
              Y: 2026
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              Value: 1349
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