Development of a deep-learning algorithm for etiological classification of subarachnoid hemorrhage using non-contrast CT scans.
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| Title: | Development of a deep-learning algorithm for etiological classification of subarachnoid hemorrhage using non-contrast CT scans. |
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| Authors: | Chen, Lingxu1,2 (AUTHOR), Wang, Xiaochen1,2 (AUTHOR), Li, Yuanjun3 (AUTHOR), Bao, Yang4 (AUTHOR), Wang, Sihui1 (AUTHOR), Zhao, Xuening1 (AUTHOR), Yuan, Mengyuan1 (AUTHOR), Kang, Jianghe3 (AUTHOR), Sun, Shengjun1,2 (AUTHOR) sunshengjun0212@163.com |
| Source: | European Radiology. Nov2025, Vol. 35 Issue 11, p6775-6784. 10p. |
| Subjects: | Subarachnoid hemorrhage, Deep learning, Classification, Computed tomography |
| Abstract: | Objectives: This study aims to develop a deep learning algorithm for differentiating aneurysmal subarachnoid hemorrhage (aSAH) from non-aneurysmal subarachnoid hemorrhage (naSAH) using non-contrast computed tomography (NCCT) scans. Methods: This retrospective study included 618 patients diagnosed with SAH. The dataset was divided into a training and internal validation cohort (533 cases: aSAH = 305, naSAH = 228) and an external test cohort (85 cases: aSAH = 55, naSAH = 30). Hemorrhage regions were automatically segmented using a U-Net + + architecture. A ResNet-based deep learning model was trained to classify the etiology of SAH. Results: The model achieved robust performance in distinguishing aSAH from naSAH. In the internal validation cohort, it yielded an average sensitivity of 0.898, specificity of 0.877, accuracy of 0.889, Matthews correlation coefficient (MCC) of 0.777, and an area under the curve (AUC) of 0.948 (95% CI: 0.929–0.967). In the external test cohort, the model demonstrated an average sensitivity of 0.891, specificity of 0.880, accuracy of 0.887, MCC of 0.761, and AUC of 0.914 (95% CI: 0.889–0.940), outperforming junior radiologists (average accuracy: 0.836; MCC: 0.660). Conclusion: The study presents a deep learning architecture capable of accurately identifying SAH etiology from NCCT scans. The model's high diagnostic performance highlights its potential to support rapid and precise clinical decision-making in emergency settings. Key Points: QuestionDifferentiating aneurysmal from naSAH is crucial for timely treatment, yet existing imaging modalities are not universally accessible or convenient for rapid diagnosis. FindingsA ResNet-variant-based deep learning model utilizing non-contrast CT scans demonstrated high accuracy in classifying SAH etiology and enhanced junior radiologists' diagnostic performance. Clinical relevanceAI-driven analysis of non-contrast CT scans provides a fast, cost-effective, and non-invasive solution for preoperative SAH diagnosis. This approach facilitates early identification of patients needing aneurysm surgery while minimizing unnecessary angiography in non-aneurysmal cases, enhancing clinical workflow efficiency. [ABSTRACT FROM AUTHOR] |
| Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
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| Header | DbId: egs DbLabel: Engineering Source An: 188901889 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Development of a deep-learning algorithm for etiological classification of subarachnoid hemorrhage using non-contrast CT scans. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Chen%2C+Lingxu%22">Chen, Lingxu</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wang%2C+Xiaochen%22">Wang, Xiaochen</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li%2C+Yuanjun%22">Li, Yuanjun</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bao%2C+Yang%22">Bao, Yang</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wang%2C+Sihui%22">Wang, Sihui</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhao%2C+Xuening%22">Zhao, Xuening</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yuan%2C+Mengyuan%22">Yuan, Mengyuan</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kang%2C+Jianghe%22">Kang, Jianghe</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sun%2C+Shengjun%22">Sun, Shengjun</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> sunshengjun0212@163.com</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22European+Radiology%22">European Radiology</searchLink>. Nov2025, Vol. 35 Issue 11, p6775-6784. 10p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Subarachnoid+hemorrhage%22">Subarachnoid hemorrhage</searchLink><br /><searchLink fieldCode="DE" term="%22Deep+learning%22">Deep learning</searchLink><br /><searchLink fieldCode="DE" term="%22Classification%22">Classification</searchLink><br /><searchLink fieldCode="DE" term="%22Computed+tomography%22">Computed tomography</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Objectives: This study aims to develop a deep learning algorithm for differentiating aneurysmal subarachnoid hemorrhage (aSAH) from non-aneurysmal subarachnoid hemorrhage (naSAH) using non-contrast computed tomography (NCCT) scans. Methods: This retrospective study included 618 patients diagnosed with SAH. The dataset was divided into a training and internal validation cohort (533 cases: aSAH = 305, naSAH = 228) and an external test cohort (85 cases: aSAH = 55, naSAH = 30). Hemorrhage regions were automatically segmented using a U-Net + + architecture. A ResNet-based deep learning model was trained to classify the etiology of SAH. Results: The model achieved robust performance in distinguishing aSAH from naSAH. In the internal validation cohort, it yielded an average sensitivity of 0.898, specificity of 0.877, accuracy of 0.889, Matthews correlation coefficient (MCC) of 0.777, and an area under the curve (AUC) of 0.948 (95% CI: 0.929–0.967). In the external test cohort, the model demonstrated an average sensitivity of 0.891, specificity of 0.880, accuracy of 0.887, MCC of 0.761, and AUC of 0.914 (95% CI: 0.889–0.940), outperforming junior radiologists (average accuracy: 0.836; MCC: 0.660). Conclusion: The study presents a deep learning architecture capable of accurately identifying SAH etiology from NCCT scans. The model's high diagnostic performance highlights its potential to support rapid and precise clinical decision-making in emergency settings. Key Points: QuestionDifferentiating aneurysmal from naSAH is crucial for timely treatment, yet existing imaging modalities are not universally accessible or convenient for rapid diagnosis. FindingsA ResNet-variant-based deep learning model utilizing non-contrast CT scans demonstrated high accuracy in classifying SAH etiology and enhanced junior radiologists' diagnostic performance. Clinical relevanceAI-driven analysis of non-contrast CT scans provides a fast, cost-effective, and non-invasive solution for preoperative SAH diagnosis. This approach facilitates early identification of patients needing aneurysm surgery while minimizing unnecessary angiography in non-aneurysmal cases, enhancing clinical workflow efficiency. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00330-025-11666-2 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 10 StartPage: 6775 Subjects: – SubjectFull: Subarachnoid hemorrhage Type: general – SubjectFull: Deep learning Type: general – SubjectFull: Classification Type: general – SubjectFull: Computed tomography Type: general Titles: – TitleFull: Development of a deep-learning algorithm for etiological classification of subarachnoid hemorrhage using non-contrast CT scans. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Chen, Lingxu – PersonEntity: Name: NameFull: Wang, Xiaochen – PersonEntity: Name: NameFull: Li, Yuanjun – PersonEntity: Name: NameFull: Bao, Yang – PersonEntity: Name: NameFull: Wang, Sihui – PersonEntity: Name: NameFull: Zhao, Xuening – PersonEntity: Name: NameFull: Yuan, Mengyuan – PersonEntity: Name: NameFull: Kang, Jianghe – PersonEntity: Name: NameFull: Sun, Shengjun IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 11 Text: Nov2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 09387994 Numbering: – Type: volume Value: 35 – Type: issue Value: 11 Titles: – TitleFull: European Radiology Type: main |
| ResultId | 1 |
