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Fructooligosaccharides and immune health: immunomodulatory effects via gut microbiota and direct molecular mechanisms.

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Title: Fructooligosaccharides and immune health: immunomodulatory effects via gut microbiota and direct molecular mechanisms.
Authors: Yap, Bryan Ju Min1 (AUTHOR), Yeo, Siok Koon1 (AUTHOR), Ng, Woei Kean2 (AUTHOR), Yong, Phelim Voon Chen3 (AUTHOR), Teo, Andrew4,5 (AUTHOR), Chua, Caroline Lin Lin1 (AUTHOR) Linlin.chua@taylors.edu.my
Source: International Journal of Food Sciences & Nutrition. Nov2025, Vol. 76 Issue 7, p675-688. 14p.
Subjects: Fructooligosaccharides, Gut microbiota, Immunoregulation, Epithelial cells, Immunological tolerance, Immunologic diseases, Inflammatory mediators, Short-chain fatty acids
Abstract: Fructooligosaccharides, a prebiotic oligosaccharide, are gaining attention for their beneficial effects on immune health. These benefits are often linked to their ability to promote the growth of beneficial gut bacteria, which produce metabolites such as short-chain fatty acids with immunomodulatory properties. In addition, FOS may have direct immunomodulatory roles by interacting with carbohydrate-binding receptors on epithelial and immune cells, including monocytes, macrophages and dendritic cells. These interactions can initiate distinct downstream responses, such as suppressing pro-inflammatory cytokine production,and inducing immune tolerance. In this review, we will discuss recent findings on the mechanisms of immune modulation following FOS supplementation and their potential applications in various disease settings. Additionally, we aim to present current evidence supporting the direct immunomodulatory effects of FOS on immune and epithelial cells. Finally, we will identify existing knowledge gaps and propose future research directions to advance our understanding of FOS in immune health. [ABSTRACT FROM AUTHOR]
Copyright of International Journal of Food Sciences & Nutrition is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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DbLabel: Engineering Source
An: 188923766
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PubType: Academic Journal
PubTypeId: academicJournal
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  Data: Fructooligosaccharides and immune health: immunomodulatory effects via gut microbiota and direct molecular mechanisms.
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  Data: <searchLink fieldCode="AR" term="%22Yap%2C+Bryan+Ju+Min%22">Yap, Bryan Ju Min</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yeo%2C+Siok+Koon%22">Yeo, Siok Koon</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ng%2C+Woei+Kean%22">Ng, Woei Kean</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yong%2C+Phelim+Voon+Chen%22">Yong, Phelim Voon Chen</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Teo%2C+Andrew%22">Teo, Andrew</searchLink><relatesTo>4,5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chua%2C+Caroline+Lin+Lin%22">Chua, Caroline Lin Lin</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> Linlin.chua@taylors.edu.my</i>
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  Data: <searchLink fieldCode="JN" term="%22International+Journal+of+Food+Sciences+%26+Nutrition%22">International Journal of Food Sciences & Nutrition</searchLink>. Nov2025, Vol. 76 Issue 7, p675-688. 14p.
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  Data: <searchLink fieldCode="DE" term="%22Fructooligosaccharides%22">Fructooligosaccharides</searchLink><br /><searchLink fieldCode="DE" term="%22Gut+microbiota%22">Gut microbiota</searchLink><br /><searchLink fieldCode="DE" term="%22Immunoregulation%22">Immunoregulation</searchLink><br /><searchLink fieldCode="DE" term="%22Epithelial+cells%22">Epithelial cells</searchLink><br /><searchLink fieldCode="DE" term="%22Immunological+tolerance%22">Immunological tolerance</searchLink><br /><searchLink fieldCode="DE" term="%22Immunologic+diseases%22">Immunologic diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Inflammatory+mediators%22">Inflammatory mediators</searchLink><br /><searchLink fieldCode="DE" term="%22Short-chain+fatty+acids%22">Short-chain fatty acids</searchLink>
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  Label: Abstract
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  Data: Fructooligosaccharides, a prebiotic oligosaccharide, are gaining attention for their beneficial effects on immune health. These benefits are often linked to their ability to promote the growth of beneficial gut bacteria, which produce metabolites such as short-chain fatty acids with immunomodulatory properties. In addition, FOS may have direct immunomodulatory roles by interacting with carbohydrate-binding receptors on epithelial and immune cells, including monocytes, macrophages and dendritic cells. These interactions can initiate distinct downstream responses, such as suppressing pro-inflammatory cytokine production,and inducing immune tolerance. In this review, we will discuss recent findings on the mechanisms of immune modulation following FOS supplementation and their potential applications in various disease settings. Additionally, we aim to present current evidence supporting the direct immunomodulatory effects of FOS on immune and epithelial cells. Finally, we will identify existing knowledge gaps and propose future research directions to advance our understanding of FOS in immune health. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Group: Ab
  Data: <i>Copyright of International Journal of Food Sciences & Nutrition is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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        Value: 10.1080/09637486.2025.2568677
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      – Code: eng
        Text: English
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        PageCount: 14
        StartPage: 675
    Subjects:
      – SubjectFull: Fructooligosaccharides
        Type: general
      – SubjectFull: Gut microbiota
        Type: general
      – SubjectFull: Immunoregulation
        Type: general
      – SubjectFull: Epithelial cells
        Type: general
      – SubjectFull: Immunological tolerance
        Type: general
      – SubjectFull: Immunologic diseases
        Type: general
      – SubjectFull: Inflammatory mediators
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      – SubjectFull: Short-chain fatty acids
        Type: general
    Titles:
      – TitleFull: Fructooligosaccharides and immune health: immunomodulatory effects via gut microbiota and direct molecular mechanisms.
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            NameFull: Yap, Bryan Ju Min
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            NameFull: Yeo, Siok Koon
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            NameFull: Yong, Phelim Voon Chen
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              M: 11
              Text: Nov2025
              Type: published
              Y: 2025
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