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Evaluation of Biocompatibility and In Vivo Response of Electrospun PLA/Nd2O3 Nanocomposite Fibers for Biomedical Scaffolding Applications.

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Title: Evaluation of Biocompatibility and In Vivo Response of Electrospun PLA/Nd2O3 Nanocomposite Fibers for Biomedical Scaffolding Applications.
Authors: Rajan, Anju1 (AUTHOR), Balakrishnan, Raneesh1 (AUTHOR) raneesh.b@catholicatecollege.ac.in, Mohanan, Rishi1 (AUTHOR), Shylaja, Karthika1 (AUTHOR) drkarthikarajiv@gmail.com, Dalvi, Yogesh Bharat2 (AUTHOR), Thomas, Nebu George2 (AUTHOR), Sreekumar, Akshara2 (AUTHOR), Varghese, Ruby3 (AUTHOR)
Source: Polymers for Advanced Technologies. Oct2025, Vol. 36 Issue 10, p1-14. 14p.
Subjects: Biocompatibility, Tissue scaffolds, Cytocompatibility, Nanocomposite materials, Polylactic acid, Tissue engineering, Rare earth oxides, Synthetic fibers
Abstract: Electrospun polylactic acid (PLA) fibers incorporating low concentrations of neodymium oxide (Nd2O3) nanoparticles were fabricated and evaluated as scaffolds. Structural and physicochemical characteristics were analyzed by X‐ray diffraction, Fourier transform infrared spectroscopy, field emission scanning electron microscopy, tensile testing, and differential scanning calorimetry. Wettability was determined by water contact angle measurements. In vitro assays demonstrated cytocompatibility with L929 fibroblasts, favorable migration in scratch closure tests, and acceptable hemocompatibility. Colony‐forming unit assays with Methicillin‐Resistant Staphylococcus aureus (MRSA) showed a moderate reduction in bacterial counts. Short‐term subcutaneous implantation in Sprague Dawley rats indicated tissue tolerance without an acute inflammatory response, while the chorioallantoic membrane assay indicated enhanced local angiogenesis. The results indicate that Nd2O3 modified PLA scaffolds maintain structural stability, improve surface wettability, and support early cellular and tissue responses. These findings highlight the potential of Nd2O3‐incorporated PLA fibers as biomaterial candidates for regenerative applications. [ABSTRACT FROM AUTHOR]
Copyright of Polymers for Advanced Technologies is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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Header DbId: egs
DbLabel: Engineering Source
An: 188962532
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Evaluation of Biocompatibility and In Vivo Response of Electrospun PLA/Nd<subscript>2</subscript>O<subscript>3</subscript> Nanocomposite Fibers for Biomedical Scaffolding Applications.
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  Data: <searchLink fieldCode="AR" term="%22Rajan%2C+Anju%22">Rajan, Anju</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Balakrishnan%2C+Raneesh%22">Balakrishnan, Raneesh</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> raneesh.b@catholicatecollege.ac.in</i><br /><searchLink fieldCode="AR" term="%22Mohanan%2C+Rishi%22">Mohanan, Rishi</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Shylaja%2C+Karthika%22">Shylaja, Karthika</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> drkarthikarajiv@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Dalvi%2C+Yogesh+Bharat%22">Dalvi, Yogesh Bharat</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Thomas%2C+Nebu+George%22">Thomas, Nebu George</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sreekumar%2C+Akshara%22">Sreekumar, Akshara</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Varghese%2C+Ruby%22">Varghese, Ruby</searchLink><relatesTo>3</relatesTo> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Polymers+for+Advanced+Technologies%22">Polymers for Advanced Technologies</searchLink>. Oct2025, Vol. 36 Issue 10, p1-14. 14p.
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  Data: <searchLink fieldCode="DE" term="%22Biocompatibility%22">Biocompatibility</searchLink><br /><searchLink fieldCode="DE" term="%22Tissue+scaffolds%22">Tissue scaffolds</searchLink><br /><searchLink fieldCode="DE" term="%22Cytocompatibility%22">Cytocompatibility</searchLink><br /><searchLink fieldCode="DE" term="%22Nanocomposite+materials%22">Nanocomposite materials</searchLink><br /><searchLink fieldCode="DE" term="%22Polylactic+acid%22">Polylactic acid</searchLink><br /><searchLink fieldCode="DE" term="%22Tissue+engineering%22">Tissue engineering</searchLink><br /><searchLink fieldCode="DE" term="%22Rare+earth+oxides%22">Rare earth oxides</searchLink><br /><searchLink fieldCode="DE" term="%22Synthetic+fibers%22">Synthetic fibers</searchLink>
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  Label: Abstract
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  Data: Electrospun polylactic acid (PLA) fibers incorporating low concentrations of neodymium oxide (Nd2O3) nanoparticles were fabricated and evaluated as scaffolds. Structural and physicochemical characteristics were analyzed by X‐ray diffraction, Fourier transform infrared spectroscopy, field emission scanning electron microscopy, tensile testing, and differential scanning calorimetry. Wettability was determined by water contact angle measurements. In vitro assays demonstrated cytocompatibility with L929 fibroblasts, favorable migration in scratch closure tests, and acceptable hemocompatibility. Colony‐forming unit assays with Methicillin‐Resistant Staphylococcus aureus (MRSA) showed a moderate reduction in bacterial counts. Short‐term subcutaneous implantation in Sprague Dawley rats indicated tissue tolerance without an acute inflammatory response, while the chorioallantoic membrane assay indicated enhanced local angiogenesis. The results indicate that Nd2O3 modified PLA scaffolds maintain structural stability, improve surface wettability, and support early cellular and tissue responses. These findings highlight the potential of Nd2O3‐incorporated PLA fibers as biomaterial candidates for regenerative applications. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Polymers for Advanced Technologies is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1002/pat.70394
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        Text: English
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        PageCount: 14
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      – SubjectFull: Biocompatibility
        Type: general
      – SubjectFull: Tissue scaffolds
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      – SubjectFull: Cytocompatibility
        Type: general
      – SubjectFull: Nanocomposite materials
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      – SubjectFull: Polylactic acid
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      – SubjectFull: Tissue engineering
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      – SubjectFull: Rare earth oxides
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      – SubjectFull: Synthetic fibers
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      – TitleFull: Evaluation of Biocompatibility and In Vivo Response of Electrospun PLA/Nd2O3 Nanocomposite Fibers for Biomedical Scaffolding Applications.
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              M: 10
              Text: Oct2025
              Type: published
              Y: 2025
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