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A Novel Port to Facilitate Magnetic Hyperthermia Therapy for Glioma.

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Title: A Novel Port to Facilitate Magnetic Hyperthermia Therapy for Glioma.
Authors: Rodriguez, Benjamin1, Campbell, Peter1, Borrello, Joseph1, Odland, Ian1, Williams, Tyree2, Hrabarchuk, Eugene I.1, Young, Tirone1, Sharma, Anirudh3, Schupper, Alexander J.4, Rapoport, Benjamin1, Ivkov, Robert3, Hadjipanayis, Constantinos5
Source: Journal of Biomechanical Engineering. 2024, p1-8. 8p.
Subjects: Magnetic nanoparticle hyperthermia, Gliomas, Magnetic nanoparticles, Cooperation, Rapid prototyping, Medical equipment, Cancer treatment, Medical innovations
Abstract: High-grade gliomas (HGG) are the most common primary brain malignancy and continue to be associated with a dismal prognosis (median survival rate of 15-18 months) with standard of care therapy. Magnetic hyperthermia therapy (MHT) is an emerging intervention that leverages the ferromagnetic properties of magnetic iron-oxide nanoparticles (MIONPs) to target cancer cells that are otherwise left behind after resection. We report a novel port device to facilitate localization, delivery, and temperature measurement of MIONPs within a target lesion for MHT therapy. We conducted an in-depth literature and intellectual property review to define specifications of the conceived port device. After setting the design parameters, a thorough collaboration with neurological surgeons guided the iterative modeling process. A prototype was developed using Fusion 360 (Autodesk, San Rafael, CA) and printed on a Form 3 printer (Formlabs, Medford, MA) in Durable resin. The prototype was then tested in a phantom skull printed on a Pro-Jet 660Pro 3D printer (3D Systems, Rock Hill, SC) and a brain model based on mechanical and electrochemical properties of native brain tissue. This phantom underwent MHT heating tests using an alternating magnetic field (AMF) sequence based on current MHT workflow. Successful localization, delivery, and temperature measurement were demonstrated. The purpose of this study was twofold: first, to create and validate the procedural framework for a novel device, providing the groundwork for an upcoming comprehensive animal trial and second, to elucidate a cooperative approach between engineers and clinicians that propels advancements in medical innovation. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Biomechanical Engineering is the property of American Society of Mechanical Engineers and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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DbLabel: Engineering Source
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PubType: Academic Journal
PubTypeId: academicJournal
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  Data: A Novel Port to Facilitate Magnetic Hyperthermia Therapy for Glioma.
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  Data: High-grade gliomas (HGG) are the most common primary brain malignancy and continue to be associated with a dismal prognosis (median survival rate of 15-18 months) with standard of care therapy. Magnetic hyperthermia therapy (MHT) is an emerging intervention that leverages the ferromagnetic properties of magnetic iron-oxide nanoparticles (MIONPs) to target cancer cells that are otherwise left behind after resection. We report a novel port device to facilitate localization, delivery, and temperature measurement of MIONPs within a target lesion for MHT therapy. We conducted an in-depth literature and intellectual property review to define specifications of the conceived port device. After setting the design parameters, a thorough collaboration with neurological surgeons guided the iterative modeling process. A prototype was developed using Fusion 360 (Autodesk, San Rafael, CA) and printed on a Form 3 printer (Formlabs, Medford, MA) in Durable resin. The prototype was then tested in a phantom skull printed on a Pro-Jet 660Pro 3D printer (3D Systems, Rock Hill, SC) and a brain model based on mechanical and electrochemical properties of native brain tissue. This phantom underwent MHT heating tests using an alternating magnetic field (AMF) sequence based on current MHT workflow. Successful localization, delivery, and temperature measurement were demonstrated. The purpose of this study was twofold: first, to create and validate the procedural framework for a novel device, providing the groundwork for an upcoming comprehensive animal trial and second, to elucidate a cooperative approach between engineers and clinicians that propels advancements in medical innovation. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Journal of Biomechanical Engineering is the property of American Society of Mechanical Engineers and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=189278997
RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1115/1.4063556
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 8
        StartPage: 1
    Subjects:
      – SubjectFull: Magnetic nanoparticle hyperthermia
        Type: general
      – SubjectFull: Gliomas
        Type: general
      – SubjectFull: Magnetic nanoparticles
        Type: general
      – SubjectFull: Cooperation
        Type: general
      – SubjectFull: Rapid prototyping
        Type: general
      – SubjectFull: Medical equipment
        Type: general
      – SubjectFull: Cancer treatment
        Type: general
      – SubjectFull: Medical innovations
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      – TitleFull: A Novel Port to Facilitate Magnetic Hyperthermia Therapy for Glioma.
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            NameFull: Rodriguez, Benjamin
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            – D: 01
              M: 01
              Text: 2024
              Type: published
              Y: 2024
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