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Suppression of sex-ratio drive in Drosophila subobscura.

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Title: Suppression of sex-ratio drive in Drosophila subobscura.
Authors: Lyth, Sophie1 (AUTHOR), Gill, Tom1 (AUTHOR), Manser, Andri2 (AUTHOR), Tanianis, Jolanta1 (AUTHOR), Hurst, Gregory D D1 (AUTHOR), Betancourt, Andrea J1 (AUTHOR), Price, Thomas A R1 (AUTHOR), Verspoor, Rudi L1,3 (AUTHOR)
Source: Evolution. Nov2025, Vol. 79 Issue 11, p2394-2405. 12p.
Subjects: Sex ratio, Drosophila, X chromosome, Genetics, Germ cells, Suppressor mutation, Fertility
Geographic Terms: North Africa
Abstract: Selfish genetic elements enjoy an evolutionary advantage by enhancing their own transmission to offspring, and their genetic suppressors are favored when they re-establish fair inheritance patterns. Here, we study an X-linked sex ratio drive system (SR) in Drosophila subobscura , which kills Y-bearing sperm of SR males, resulting in the over-transmission of the SR chromosome and a strong female bias in their offspring. We surveyed D. subobscura populations in North Africa, which naturally harbor SR, and found that suppression occurs in ∼13.5% of wild-derived lines. We characterize this suppression phenotype through a series of crossing experiments, including multigenerational introgression of SR chromosomes into a suppressing genetic background. We show that introgression can restore normal offspring sex ratios or, in some cases, result in an excess of male offspring. This suppression appears to be a multilocus trait, involving autosomes and the Y chromosomes. Suppression of SR fails to ameliorate all costs of drive, with fully suppressed SR-carrying males having depressed fertility and low offspring egg hatch rates. Further examination of internal male reproductive organs using microscopy suggests that suppressed SR males also have abnormal testes. These factors may explain why the suppression fails to reach high frequencies, despite the strong advantage of suppressing SR. [ABSTRACT FROM AUTHOR]
Copyright of Evolution is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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DbLabel: Engineering Source
An: 189452027
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Suppression of sex-ratio drive in Drosophila subobscura.
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  Data: <searchLink fieldCode="AR" term="%22Lyth%2C+Sophie%22">Lyth, Sophie</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gill%2C+Tom%22">Gill, Tom</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Manser%2C+Andri%22">Manser, Andri</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tanianis%2C+Jolanta%22">Tanianis, Jolanta</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hurst%2C+Gregory+D+D%22">Hurst, Gregory D D</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Betancourt%2C+Andrea+J%22">Betancourt, Andrea J</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Price%2C+Thomas+A+R%22">Price, Thomas A R</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Verspoor%2C+Rudi+L%22">Verspoor, Rudi L</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Evolution%22">Evolution</searchLink>. Nov2025, Vol. 79 Issue 11, p2394-2405. 12p.
– Name: Subject
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  Data: <searchLink fieldCode="DE" term="%22Sex+ratio%22">Sex ratio</searchLink><br /><searchLink fieldCode="DE" term="%22Drosophila%22">Drosophila</searchLink><br /><searchLink fieldCode="DE" term="%22X+chromosome%22">X chromosome</searchLink><br /><searchLink fieldCode="DE" term="%22Genetics%22">Genetics</searchLink><br /><searchLink fieldCode="DE" term="%22Germ+cells%22">Germ cells</searchLink><br /><searchLink fieldCode="DE" term="%22Suppressor+mutation%22">Suppressor mutation</searchLink><br /><searchLink fieldCode="DE" term="%22Fertility%22">Fertility</searchLink>
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  Data: <searchLink fieldCode="DE" term="%22North+Africa%22">North Africa</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Selfish genetic elements enjoy an evolutionary advantage by enhancing their own transmission to offspring, and their genetic suppressors are favored when they re-establish fair inheritance patterns. Here, we study an X-linked sex ratio drive system (SR) in Drosophila subobscura , which kills Y-bearing sperm of SR males, resulting in the over-transmission of the SR chromosome and a strong female bias in their offspring. We surveyed D. subobscura populations in North Africa, which naturally harbor SR, and found that suppression occurs in ∼13.5% of wild-derived lines. We characterize this suppression phenotype through a series of crossing experiments, including multigenerational introgression of SR chromosomes into a suppressing genetic background. We show that introgression can restore normal offspring sex ratios or, in some cases, result in an excess of male offspring. This suppression appears to be a multilocus trait, involving autosomes and the Y chromosomes. Suppression of SR fails to ameliorate all costs of drive, with fully suppressed SR-carrying males having depressed fertility and low offspring egg hatch rates. Further examination of internal male reproductive organs using microscopy suggests that suppressed SR males also have abnormal testes. These factors may explain why the suppression fails to reach high frequencies, despite the strong advantage of suppressing SR. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Evolution is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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    Identifiers:
      – Type: doi
        Value: 10.1093/evolut/qpaf153
    Languages:
      – Code: eng
        Text: English
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      Pagination:
        PageCount: 12
        StartPage: 2394
    Subjects:
      – SubjectFull: Sex ratio
        Type: general
      – SubjectFull: Drosophila
        Type: general
      – SubjectFull: X chromosome
        Type: general
      – SubjectFull: Genetics
        Type: general
      – SubjectFull: Germ cells
        Type: general
      – SubjectFull: Suppressor mutation
        Type: general
      – SubjectFull: Fertility
        Type: general
      – SubjectFull: North Africa
        Type: general
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      – TitleFull: Suppression of sex-ratio drive in Drosophila subobscura.
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            NameFull: Lyth, Sophie
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            NameFull: Gill, Tom
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            – D: 01
              M: 11
              Text: Nov2025
              Type: published
              Y: 2025
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              Value: 79
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