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Recent progress towards catalytic asymmetric construction of inherently chiral scaffolds.

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Title: Recent progress towards catalytic asymmetric construction of inherently chiral scaffolds.
Authors: Zhu, Kai1 (AUTHOR), Spring, David R.2 (AUTHOR) spring@ch.cam.ac.uk, Shi, Bing-Feng3 (AUTHOR) bfshi@zju.edu.cn, Zhang, Fengzhi4 (AUTHOR) zhangfengzhi@hmc.edu.cn
Source: Chemical Society Reviews. 12/7/2025, Vol. 54 Issue 23, p10856-10879. 24p.
Subjects: Asymmetric synthesis, Chirality, Molecular recognition, Materials science, Pharmaceutical chemistry, Enantioselective catalysis
Abstract: Inherently chiral scaffolds are a unique type of structurally fascinating building blocks, which have found increasing applications in the field of material chemistry, medicinal chemistry, asymmetric synthesis, molecular recognition and assembly. Owing to the steady demand for these chiral entities, numerous efforts have been made on their enantioselective synthesis. Among the plethora of accomplishments reported, the catalytic asymmetric strategy is emerging as one of the most efficient and sustainable approaches. This protocol provides a powerful platform to achieve enantiomerically pure inherently chiral architectures with structural diversity. In this review article, we aim to generalize the booming and remarkable advancements in asymmetric synthesis of inherently chiral calix[n]arenes, pillar[n]arenes, saddle-shaped scaffolds, mechanically interlocked molecules, and prism-like cages under catalyst control, which would offer valuable insights for future research on the rational design of conceptually novel and streamlined asymmetric synthetic systems, thereby expanding the scope/chemical space and improving the added value of inherently chiral molecules. [ABSTRACT FROM AUTHOR]
Copyright of Chemical Society Reviews is the property of Royal Society of Chemistry and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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  Data: Recent progress towards catalytic asymmetric construction of inherently chiral scaffolds.
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  Data: <searchLink fieldCode="DE" term="%22Asymmetric+synthesis%22">Asymmetric synthesis</searchLink><br /><searchLink fieldCode="DE" term="%22Chirality%22">Chirality</searchLink><br /><searchLink fieldCode="DE" term="%22Molecular+recognition%22">Molecular recognition</searchLink><br /><searchLink fieldCode="DE" term="%22Materials+science%22">Materials science</searchLink><br /><searchLink fieldCode="DE" term="%22Pharmaceutical+chemistry%22">Pharmaceutical chemistry</searchLink><br /><searchLink fieldCode="DE" term="%22Enantioselective+catalysis%22">Enantioselective catalysis</searchLink>
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  Data: Inherently chiral scaffolds are a unique type of structurally fascinating building blocks, which have found increasing applications in the field of material chemistry, medicinal chemistry, asymmetric synthesis, molecular recognition and assembly. Owing to the steady demand for these chiral entities, numerous efforts have been made on their enantioselective synthesis. Among the plethora of accomplishments reported, the catalytic asymmetric strategy is emerging as one of the most efficient and sustainable approaches. This protocol provides a powerful platform to achieve enantiomerically pure inherently chiral architectures with structural diversity. In this review article, we aim to generalize the booming and remarkable advancements in asymmetric synthesis of inherently chiral calix[n]arenes, pillar[n]arenes, saddle-shaped scaffolds, mechanically interlocked molecules, and prism-like cages under catalyst control, which would offer valuable insights for future research on the rational design of conceptually novel and streamlined asymmetric synthetic systems, thereby expanding the scope/chemical space and improving the added value of inherently chiral molecules. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Chemical Society Reviews is the property of Royal Society of Chemistry and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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    Identifiers:
      – Type: doi
        Value: 10.1039/d5cs00235d
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      – Code: eng
        Text: English
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        PageCount: 24
        StartPage: 10856
    Subjects:
      – SubjectFull: Asymmetric synthesis
        Type: general
      – SubjectFull: Chirality
        Type: general
      – SubjectFull: Molecular recognition
        Type: general
      – SubjectFull: Materials science
        Type: general
      – SubjectFull: Pharmaceutical chemistry
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      – SubjectFull: Enantioselective catalysis
        Type: general
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      – TitleFull: Recent progress towards catalytic asymmetric construction of inherently chiral scaffolds.
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            NameFull: Zhu, Kai
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            NameFull: Spring, David R.
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            NameFull: Shi, Bing-Feng
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            NameFull: Zhang, Fengzhi
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            – D: 07
              M: 12
              Text: 12/7/2025
              Type: published
              Y: 2025
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