Complications in chemical and thermal ablation of parathyroid lesions: a systematic review and meta-analysis.
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| Title: | Complications in chemical and thermal ablation of parathyroid lesions: a systematic review and meta-analysis. |
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| Authors: | Jeong, So Yeong1 (AUTHOR), Cho, Se Jin1 (AUTHOR) sejinchorad@gmail.com, Baek, Jung Hwan2 (AUTHOR) radbaek@naver.com |
| Source: | European Radiology. Dec2025, Vol. 35 Issue 12, p7738-7751. 14p. |
| Subjects: | Minimally invasive procedures, Surgical complications, Ablation techniques, Radio frequency therapy, Parathyroid glands, Hyperparathyroidism |
| Abstract: | Objectives: Minimally invasive treatments such as ethanol ablation (EA), microwave ablation (MWA), and radiofrequency ablation (RFA) are options for parathyroid lesion treatment, especially in patients ineligible for or declining surgery. We aimed to assess the safety of minimally invasive treatments for parathyroid lesions. Materials and methods: PubMed and Embase were searched for original literature published on or before September 27, 2023, and 34 studies with 2102 patients (12 EA, 1 laser ablation, 10 MWA, 10 RFA, 1 both EA and RFA) were included. The pooled incidence of complications associated with chemical or thermal ablation was calculated. Subgroup analyses were performed according to ablation method and type of hyperparathyroidism (primary hyperparathyroidism (PHPT) and secondary hyperparathyroidism (SHPT)). Results: The overall pooled incidences of total, major, and minor complications were 19.1%, 5%, and 12.7%, respectively. Among complications, incidences of permanent and transient voice change were 2.7% and 8.9%, respectively. In subgroup analysis, the incidence of major complications was significantly higher in MWA than in EA or RFA (p = 0.032), whereas total and minor complications were higher in MWA than others, but there was no statistical significance. The pooled incidence of major complications was significantly higher in SHPT than in PHPT (1.9% vs.11.0%, p = 0.024). Conclusions: The overall incidences of total, major, and minor complications were 19.1%, 5%, and 12.7%, respectively. Patients treated with MWA had a significantly higher incidence of major complications than patients treated with other methods. Patients with SHPT had a significantly higher incidence of major complications compared with patients with PHPT. Key Points: QuestionWhat are the safety outcomes of minimally invasive treatments, including chemical or thermal ablation, for patients with parathyroid lesions? FindingsOverall incidences of total, major, and minor complications were 19.1%, 5%, and 12.7%, and of permanent and transient voice change were 2.7% and 8.9%. Clinical relevanceMicrowave ablation demonstrated significantly higher major complication rates than other chemical or thermal ablation methods. Patients with secondary hyperparathyroidism showed significantly higher major complication rates than patients with primary hyperparathyroidism. [ABSTRACT FROM AUTHOR] |
| Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 189534069 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Complications in chemical and thermal ablation of parathyroid lesions: a systematic review and meta-analysis. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Jeong%2C+So+Yeong%22">Jeong, So Yeong</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cho%2C+Se+Jin%22">Cho, Se Jin</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> sejinchorad@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Baek%2C+Jung+Hwan%22">Baek, Jung Hwan</searchLink><relatesTo>2</relatesTo> (AUTHOR)<i> radbaek@naver.com</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22European+Radiology%22">European Radiology</searchLink>. Dec2025, Vol. 35 Issue 12, p7738-7751. 14p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Minimally+invasive+procedures%22">Minimally invasive procedures</searchLink><br /><searchLink fieldCode="DE" term="%22Surgical+complications%22">Surgical complications</searchLink><br /><searchLink fieldCode="DE" term="%22Ablation+techniques%22">Ablation techniques</searchLink><br /><searchLink fieldCode="DE" term="%22Radio+frequency+therapy%22">Radio frequency therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Parathyroid+glands%22">Parathyroid glands</searchLink><br /><searchLink fieldCode="DE" term="%22Hyperparathyroidism%22">Hyperparathyroidism</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Objectives: Minimally invasive treatments such as ethanol ablation (EA), microwave ablation (MWA), and radiofrequency ablation (RFA) are options for parathyroid lesion treatment, especially in patients ineligible for or declining surgery. We aimed to assess the safety of minimally invasive treatments for parathyroid lesions. Materials and methods: PubMed and Embase were searched for original literature published on or before September 27, 2023, and 34 studies with 2102 patients (12 EA, 1 laser ablation, 10 MWA, 10 RFA, 1 both EA and RFA) were included. The pooled incidence of complications associated with chemical or thermal ablation was calculated. Subgroup analyses were performed according to ablation method and type of hyperparathyroidism (primary hyperparathyroidism (PHPT) and secondary hyperparathyroidism (SHPT)). Results: The overall pooled incidences of total, major, and minor complications were 19.1%, 5%, and 12.7%, respectively. Among complications, incidences of permanent and transient voice change were 2.7% and 8.9%, respectively. In subgroup analysis, the incidence of major complications was significantly higher in MWA than in EA or RFA (p = 0.032), whereas total and minor complications were higher in MWA than others, but there was no statistical significance. The pooled incidence of major complications was significantly higher in SHPT than in PHPT (1.9% vs.11.0%, p = 0.024). Conclusions: The overall incidences of total, major, and minor complications were 19.1%, 5%, and 12.7%, respectively. Patients treated with MWA had a significantly higher incidence of major complications than patients treated with other methods. Patients with SHPT had a significantly higher incidence of major complications compared with patients with PHPT. Key Points: QuestionWhat are the safety outcomes of minimally invasive treatments, including chemical or thermal ablation, for patients with parathyroid lesions? FindingsOverall incidences of total, major, and minor complications were 19.1%, 5%, and 12.7%, and of permanent and transient voice change were 2.7% and 8.9%. Clinical relevanceMicrowave ablation demonstrated significantly higher major complication rates than other chemical or thermal ablation methods. Patients with secondary hyperparathyroidism showed significantly higher major complication rates than patients with primary hyperparathyroidism. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00330-025-11739-2 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 14 StartPage: 7738 Subjects: – SubjectFull: Minimally invasive procedures Type: general – SubjectFull: Surgical complications Type: general – SubjectFull: Ablation techniques Type: general – SubjectFull: Radio frequency therapy Type: general – SubjectFull: Parathyroid glands Type: general – SubjectFull: Hyperparathyroidism Type: general Titles: – TitleFull: Complications in chemical and thermal ablation of parathyroid lesions: a systematic review and meta-analysis. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Jeong, So Yeong – PersonEntity: Name: NameFull: Cho, Se Jin – PersonEntity: Name: NameFull: Baek, Jung Hwan IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 12 Text: Dec2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 09387994 Numbering: – Type: volume Value: 35 – Type: issue Value: 12 Titles: – TitleFull: European Radiology Type: main |
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