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Bio-Inspired Synthesis of Dual Oxide-Alginate Nanocomposites Using Guava Leaf Extract for Antibacterial and Anticancer Applications.

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Title: Bio-Inspired Synthesis of Dual Oxide-Alginate Nanocomposites Using Guava Leaf Extract for Antibacterial and Anticancer Applications.
Authors: Balasubramaniyan, G.1 (AUTHOR) physicsbala92@gmail.com, Senthilkumar, G.2 (AUTHOR), Rahman, M. Abdur3 (AUTHOR), Sasi, B.4 (AUTHOR)
Source: Journal of Cluster Science. Dec2025, Vol. 36 Issue 6, p1-14. 14p.
Abstract: Novel Tin Dioxide-copper Oxide-Alginate (SnO2-CuO-SA) and Tin Dioxide-Nickel Oxide-Alginate (SnO2-NiO-SA) nanocomposites (NCs) were prepared using Psidium guajava (P. guajava) leaf extract. X-ray diffraction (XRD) confirmed the formation of tetragonal rutile phase with average crystallite size of 67.8 nm and 58.1 nm for SnO2-CuO-SA and SnO2-NiO-SA NCs, respectively. Field emission scanning electron microscope (FESEM) analysis shows, synthesis SnO2-CuO-SA and SnO2-NiO-SA NCs formed spherical structures, with an average particles 60.77 nm and 41.59 nm, respectively. X-ray photoelectron spectroscopic (XPS) studies showed that the SnO2-CuO-SA and SnO2-NiO-SA NCs contain exclusively of C 1s, O 1s, Sn 3d, Cu 2p and Ni 2p oxidation state, respectively. The SnO2-NiO-SA NCs potential to inhibits both Gram-positive and Gram-negative strain as than SnO2-CuO-SA NCs. Moreover, the anticancer efficacy of NCs were tested using (3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide) MTT cell viability assay against Trible negative breast cancer cell (MDA-MB-231) lines. The SnO2-CuO-SA and SnO2-NiO-SA NCs exhibited IC50 value of 8.8 and 5.8 µg/mL, respectively. Antioxidant activity of SnO2-NiO-SA NCs have highest scavenging activity than SnO2-NiO-SA NCs. The results demonstrated that in vitro analysis showed SnO2-NiO-SA NCs could be promising therapeutic agents in antibacterial and anticancer treatment. [ABSTRACT FROM AUTHOR]
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Database: Engineering Source
Description
Abstract:Novel Tin Dioxide-copper Oxide-Alginate (SnO2-CuO-SA) and Tin Dioxide-Nickel Oxide-Alginate (SnO2-NiO-SA) nanocomposites (NCs) were prepared using Psidium guajava (P. guajava) leaf extract. X-ray diffraction (XRD) confirmed the formation of tetragonal rutile phase with average crystallite size of 67.8 nm and 58.1 nm for SnO2-CuO-SA and SnO2-NiO-SA NCs, respectively. Field emission scanning electron microscope (FESEM) analysis shows, synthesis SnO2-CuO-SA and SnO2-NiO-SA NCs formed spherical structures, with an average particles 60.77 nm and 41.59 nm, respectively. X-ray photoelectron spectroscopic (XPS) studies showed that the SnO2-CuO-SA and SnO2-NiO-SA NCs contain exclusively of C 1s, O 1s, Sn 3d, Cu 2p and Ni 2p oxidation state, respectively. The SnO2-NiO-SA NCs potential to inhibits both Gram-positive and Gram-negative strain as than SnO2-CuO-SA NCs. Moreover, the anticancer efficacy of NCs were tested using (3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide) MTT cell viability assay against Trible negative breast cancer cell (MDA-MB-231) lines. The SnO2-CuO-SA and SnO2-NiO-SA NCs exhibited IC50 value of 8.8 and 5.8 µg/mL, respectively. Antioxidant activity of SnO2-NiO-SA NCs have highest scavenging activity than SnO2-NiO-SA NCs. The results demonstrated that in vitro analysis showed SnO2-NiO-SA NCs could be promising therapeutic agents in antibacterial and anticancer treatment. [ABSTRACT FROM AUTHOR]
ISSN:10407278
DOI:10.1007/s10876-025-02956-2