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Bio-Inspired Synthesis of Dual Oxide-Alginate Nanocomposites Using Guava Leaf Extract for Antibacterial and Anticancer Applications.

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Title: Bio-Inspired Synthesis of Dual Oxide-Alginate Nanocomposites Using Guava Leaf Extract for Antibacterial and Anticancer Applications.
Authors: Balasubramaniyan, G.1 (AUTHOR) physicsbala92@gmail.com, Senthilkumar, G.2 (AUTHOR), Rahman, M. Abdur3 (AUTHOR), Sasi, B.4 (AUTHOR)
Source: Journal of Cluster Science. Dec2025, Vol. 36 Issue 6, p1-14. 14p.
Abstract: Novel Tin Dioxide-copper Oxide-Alginate (SnO2-CuO-SA) and Tin Dioxide-Nickel Oxide-Alginate (SnO2-NiO-SA) nanocomposites (NCs) were prepared using Psidium guajava (P. guajava) leaf extract. X-ray diffraction (XRD) confirmed the formation of tetragonal rutile phase with average crystallite size of 67.8 nm and 58.1 nm for SnO2-CuO-SA and SnO2-NiO-SA NCs, respectively. Field emission scanning electron microscope (FESEM) analysis shows, synthesis SnO2-CuO-SA and SnO2-NiO-SA NCs formed spherical structures, with an average particles 60.77 nm and 41.59 nm, respectively. X-ray photoelectron spectroscopic (XPS) studies showed that the SnO2-CuO-SA and SnO2-NiO-SA NCs contain exclusively of C 1s, O 1s, Sn 3d, Cu 2p and Ni 2p oxidation state, respectively. The SnO2-NiO-SA NCs potential to inhibits both Gram-positive and Gram-negative strain as than SnO2-CuO-SA NCs. Moreover, the anticancer efficacy of NCs were tested using (3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide) MTT cell viability assay against Trible negative breast cancer cell (MDA-MB-231) lines. The SnO2-CuO-SA and SnO2-NiO-SA NCs exhibited IC50 value of 8.8 and 5.8 µg/mL, respectively. Antioxidant activity of SnO2-NiO-SA NCs have highest scavenging activity than SnO2-NiO-SA NCs. The results demonstrated that in vitro analysis showed SnO2-NiO-SA NCs could be promising therapeutic agents in antibacterial and anticancer treatment. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Cluster Science is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Bio-Inspired Synthesis of Dual Oxide-Alginate Nanocomposites Using Guava Leaf Extract for Antibacterial and Anticancer Applications.
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  Data: <searchLink fieldCode="AR" term="%22Balasubramaniyan%2C+G%2E%22">Balasubramaniyan, G.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> physicsbala92@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Senthilkumar%2C+G%2E%22">Senthilkumar, G.</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rahman%2C+M%2E+Abdur%22">Rahman, M. Abdur</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sasi%2C+B%2E%22">Sasi, B.</searchLink><relatesTo>4</relatesTo> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Cluster+Science%22">Journal of Cluster Science</searchLink>. Dec2025, Vol. 36 Issue 6, p1-14. 14p.
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Novel Tin Dioxide-copper Oxide-Alginate (SnO2-CuO-SA) and Tin Dioxide-Nickel Oxide-Alginate (SnO2-NiO-SA) nanocomposites (NCs) were prepared using Psidium guajava (P. guajava) leaf extract. X-ray diffraction (XRD) confirmed the formation of tetragonal rutile phase with average crystallite size of 67.8 nm and 58.1 nm for SnO2-CuO-SA and SnO2-NiO-SA NCs, respectively. Field emission scanning electron microscope (FESEM) analysis shows, synthesis SnO2-CuO-SA and SnO2-NiO-SA NCs formed spherical structures, with an average particles 60.77 nm and 41.59 nm, respectively. X-ray photoelectron spectroscopic (XPS) studies showed that the SnO2-CuO-SA and SnO2-NiO-SA NCs contain exclusively of C 1s, O 1s, Sn 3d, Cu 2p and Ni 2p oxidation state, respectively. The SnO2-NiO-SA NCs potential to inhibits both Gram-positive and Gram-negative strain as than SnO2-CuO-SA NCs. Moreover, the anticancer efficacy of NCs were tested using (3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide) MTT cell viability assay against Trible negative breast cancer cell (MDA-MB-231) lines. The SnO2-CuO-SA and SnO2-NiO-SA NCs exhibited IC50 value of 8.8 and 5.8 µg/mL, respectively. Antioxidant activity of SnO2-NiO-SA NCs have highest scavenging activity than SnO2-NiO-SA NCs. The results demonstrated that in vitro analysis showed SnO2-NiO-SA NCs could be promising therapeutic agents in antibacterial and anticancer treatment. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Cluster Science is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1007/s10876-025-02956-2
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              Text: Dec2025
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