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Conformational regulation: A new strategy to tunning the ROS generation efficiency of polythiophene-based sonosensitizer.

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Title: Conformational regulation: A new strategy to tunning the ROS generation efficiency of polythiophene-based sonosensitizer.
Authors: Tang, Yuanyu1 (AUTHOR), Pang, E1 (AUTHOR), Wang, Chen1 (AUTHOR), Zhao, Shaojing1 (AUTHOR), Zheng, Xiuli2 (AUTHOR), Yao, Chaoyi1 (AUTHOR), Wang, Benhua1 (AUTHOR), Song, Xiangzhi1 (AUTHOR), Yi, Jianing1,3 (AUTHOR) yijianing@hunnu.edu.cn, Lan, Minhuan1 (AUTHOR) minhuanlan@csu.edu.cn, Wang, Pengfei1,2 (AUTHOR) wangpf@mail.ipc.ac.cn
Source: Chemical Engineering Journal. Dec2025, Vol. 526, pN.PAG-N.PAG. 1p.
Subjects: Reactive oxygen species, Glutathione, Immunological adjuvants, Polythiophenes, Tumor treatment, Tumor microenvironment
Abstract: Immunosonodynamic therapy (ISDT) has unique advantages in the treatment of deep tumors. However, the low reactive oxygen species (ROS) generation efficiency of the sonosensitizer and the high concentration of glutathione (GSH) in tumor can weaken the effectiveness of sonodynamic therapy (SDT) in activating immunogenic cell death (ICD). In this work, NLG919, an ideal immune adjuvant, was covalently coupled with a long-chain alkyl group through a disulfide bond to prepare a GSH-depleted NLG919 (C16-SS-N). Next, cationic polythiophene (PT2) was assembled with C16-SS-N through hydrophobic and π-π stacking interactions. The obtained PT2-N could be disassembled by intratumoral GSH to release PT2 and NLG919, while the GSH was oxidized into negatively charged glutathione disulfide (GSSG) which can induce the conformational change of the polythiophene backbone from twist to planar through the strong electronic interaction. Such a conformational change results in increased the conjugation degree and increasing the ROS generation efficiency of PT2 under ultrasound irradiation. The GSH-depleting immune adjuvant could further enhance the efficacy of ISDT by amplifying ICD, initiating immune response, and reversing the tumor immunosuppressive microenvironment. This work provides a new strategy to improve the ROS generation efficiency of polythiophene based sonosensitizers. [Display omitted] • GSH triggers polythiophene conformational change for enhanced ROS generation. • Depleting GSH and releasing immune adjuvant to inhibit IDO-1 and reprogram immunity • Sonodynamic therapy and immune reprogramming synergistically dual amplify immune [ABSTRACT FROM AUTHOR]
Copyright of Chemical Engineering Journal is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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Header DbId: egs
DbLabel: Engineering Source
An: 190227120
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Label: Title
  Group: Ti
  Data: Conformational regulation: A new strategy to tunning the ROS generation efficiency of polythiophene-based sonosensitizer.
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  Data: <searchLink fieldCode="AR" term="%22Tang%2C+Yuanyu%22">Tang, Yuanyu</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pang%2C+E%22">Pang, E</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wang%2C+Chen%22">Wang, Chen</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhao%2C+Shaojing%22">Zhao, Shaojing</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zheng%2C+Xiuli%22">Zheng, Xiuli</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yao%2C+Chaoyi%22">Yao, Chaoyi</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wang%2C+Benhua%22">Wang, Benhua</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Song%2C+Xiangzhi%22">Song, Xiangzhi</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yi%2C+Jianing%22">Yi, Jianing</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<i> yijianing@hunnu.edu.cn</i><br /><searchLink fieldCode="AR" term="%22Lan%2C+Minhuan%22">Lan, Minhuan</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> minhuanlan@csu.edu.cn</i><br /><searchLink fieldCode="AR" term="%22Wang%2C+Pengfei%22">Wang, Pengfei</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> wangpf@mail.ipc.ac.cn</i>
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  Data: <searchLink fieldCode="JN" term="%22Chemical+Engineering+Journal%22">Chemical Engineering Journal</searchLink>. Dec2025, Vol. 526, pN.PAG-N.PAG. 1p.
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  Data: <searchLink fieldCode="DE" term="%22Reactive+oxygen+species%22">Reactive oxygen species</searchLink><br /><searchLink fieldCode="DE" term="%22Glutathione%22">Glutathione</searchLink><br /><searchLink fieldCode="DE" term="%22Immunological+adjuvants%22">Immunological adjuvants</searchLink><br /><searchLink fieldCode="DE" term="%22Polythiophenes%22">Polythiophenes</searchLink><br /><searchLink fieldCode="DE" term="%22Tumor+treatment%22">Tumor treatment</searchLink><br /><searchLink fieldCode="DE" term="%22Tumor+microenvironment%22">Tumor microenvironment</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Immunosonodynamic therapy (ISDT) has unique advantages in the treatment of deep tumors. However, the low reactive oxygen species (ROS) generation efficiency of the sonosensitizer and the high concentration of glutathione (GSH) in tumor can weaken the effectiveness of sonodynamic therapy (SDT) in activating immunogenic cell death (ICD). In this work, NLG919, an ideal immune adjuvant, was covalently coupled with a long-chain alkyl group through a disulfide bond to prepare a GSH-depleted NLG919 (C16-SS-N). Next, cationic polythiophene (PT2) was assembled with C16-SS-N through hydrophobic and π-π stacking interactions. The obtained PT2-N could be disassembled by intratumoral GSH to release PT2 and NLG919, while the GSH was oxidized into negatively charged glutathione disulfide (GSSG) which can induce the conformational change of the polythiophene backbone from twist to planar through the strong electronic interaction. Such a conformational change results in increased the conjugation degree and increasing the ROS generation efficiency of PT2 under ultrasound irradiation. The GSH-depleting immune adjuvant could further enhance the efficacy of ISDT by amplifying ICD, initiating immune response, and reversing the tumor immunosuppressive microenvironment. This work provides a new strategy to improve the ROS generation efficiency of polythiophene based sonosensitizers. [Display omitted] • GSH triggers polythiophene conformational change for enhanced ROS generation. • Depleting GSH and releasing immune adjuvant to inhibit IDO-1 and reprogram immunity • Sonodynamic therapy and immune reprogramming synergistically dual amplify immune [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Chemical Engineering Journal is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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    Identifiers:
      – Type: doi
        Value: 10.1016/j.cej.2025.171085
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 1
        StartPage: N.PAG
    Subjects:
      – SubjectFull: Reactive oxygen species
        Type: general
      – SubjectFull: Glutathione
        Type: general
      – SubjectFull: Immunological adjuvants
        Type: general
      – SubjectFull: Polythiophenes
        Type: general
      – SubjectFull: Tumor treatment
        Type: general
      – SubjectFull: Tumor microenvironment
        Type: general
    Titles:
      – TitleFull: Conformational regulation: A new strategy to tunning the ROS generation efficiency of polythiophene-based sonosensitizer.
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              Text: Dec2025
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