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Vascular dysfunctions during radiation retinopathy.

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Title: Vascular dysfunctions during radiation retinopathy.
Authors: Niaudet, Colin1 (AUTHOR), Mathis, Thibaud2,3 (AUTHOR), Pham, Thao-Nguyen4 (AUTHOR), Quintyn, Jean-Claude5 (AUTHOR), Paris, François1,6 (AUTHOR) francois.paris@inserm.fr, Thariat, Juliette1,4 (AUTHOR) j.thariat@baclesse.unicancer.fr
Source: Radiotherapy & Oncology. Jan2026, Vol. 214, pN.PAG-N.PAG. 1p.
Subjects: Ocular tumors, Retinal diseases, Computer-assisted image analysis (Medicine), Vision disorders, Microcirculation disorders, Endothelium diseases, Therapeutics
Abstract: • Radiation retinopathy is a disabling complication from radiotherapy potentially causing blindness. • The prevalence of radiation retinopathy varies between 6 % and 40 % depending on tumor. • Early endothelial dysfunctions are precursors of functional deterioration. • Radiation retinopathy manifests as a late-onset, occlusive vascular pathology. • Mitigating early neurovascular dysfunction could prevent radiation retinopathy. Optic tissue toxicity remains a major limitation of radiation therapy for ocular, brain, skull base, and head and neck tumors. Among the most frequent complications, radiation retinopathy (RR) occurs in 6% of patients treated for extraocular tumors and in more than 40% of those with ocular tumors. After an initial asymptomatic stage characterized by vascular remodeling and chronic retinal ischemia, RR may progress to irreversible vision loss and significantly impaired quality of life. Advances in non-invasive, high-resolution imaging have improved our understanding of the molecular and cellular mechanisms underlying RR in both preclinical and clinical models. In particular, multimodal imaging—and especially optical coherence tomography angiography (OCTA)—has enabled earlier detection of RR in humans. Animal studies have highlighted vascular obstruction and rarefaction, together with early neurovascular dysfunction, as central features of the clinical phase. Beyond preventive measures such as dose constraints, biological and imaging biomarkers may help guide targeted interventions. In this review, we summarize current evidence on the sequential endothelial and neuronal alterations that drive RR and discuss molecular and cellular pathways that could inform the development of potential therapeutic strategies. [ABSTRACT FROM AUTHOR]
Copyright of Radiotherapy & Oncology is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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Header DbId: egs
DbLabel: Engineering Source
An: 190301110
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Vascular dysfunctions during radiation retinopathy.
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  Data: <searchLink fieldCode="AR" term="%22Niaudet%2C+Colin%22">Niaudet, Colin</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mathis%2C+Thibaud%22">Mathis, Thibaud</searchLink><relatesTo>2,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pham%2C+Thao-Nguyen%22">Pham, Thao-Nguyen</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Quintyn%2C+Jean-Claude%22">Quintyn, Jean-Claude</searchLink><relatesTo>5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Paris%2C+François%22">Paris, François</searchLink><relatesTo>1,6</relatesTo> (AUTHOR)<i> francois.paris@inserm.fr</i><br /><searchLink fieldCode="AR" term="%22Thariat%2C+Juliette%22">Thariat, Juliette</searchLink><relatesTo>1,4</relatesTo> (AUTHOR)<i> j.thariat@baclesse.unicancer.fr</i>
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  Data: <searchLink fieldCode="DE" term="%22Ocular+tumors%22">Ocular tumors</searchLink><br /><searchLink fieldCode="DE" term="%22Retinal+diseases%22">Retinal diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Computer-assisted+image+analysis+%28Medicine%29%22">Computer-assisted image analysis (Medicine)</searchLink><br /><searchLink fieldCode="DE" term="%22Vision+disorders%22">Vision disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Microcirculation+disorders%22">Microcirculation disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Endothelium+diseases%22">Endothelium diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Therapeutics%22">Therapeutics</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: • Radiation retinopathy is a disabling complication from radiotherapy potentially causing blindness. • The prevalence of radiation retinopathy varies between 6 % and 40 % depending on tumor. • Early endothelial dysfunctions are precursors of functional deterioration. • Radiation retinopathy manifests as a late-onset, occlusive vascular pathology. • Mitigating early neurovascular dysfunction could prevent radiation retinopathy. Optic tissue toxicity remains a major limitation of radiation therapy for ocular, brain, skull base, and head and neck tumors. Among the most frequent complications, radiation retinopathy (RR) occurs in 6% of patients treated for extraocular tumors and in more than 40% of those with ocular tumors. After an initial asymptomatic stage characterized by vascular remodeling and chronic retinal ischemia, RR may progress to irreversible vision loss and significantly impaired quality of life. Advances in non-invasive, high-resolution imaging have improved our understanding of the molecular and cellular mechanisms underlying RR in both preclinical and clinical models. In particular, multimodal imaging—and especially optical coherence tomography angiography (OCTA)—has enabled earlier detection of RR in humans. Animal studies have highlighted vascular obstruction and rarefaction, together with early neurovascular dysfunction, as central features of the clinical phase. Beyond preventive measures such as dose constraints, biological and imaging biomarkers may help guide targeted interventions. In this review, we summarize current evidence on the sequential endothelial and neuronal alterations that drive RR and discuss molecular and cellular pathways that could inform the development of potential therapeutic strategies. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Radiotherapy & Oncology is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1016/j.radonc.2025.111294
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      – Code: eng
        Text: English
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        StartPage: N.PAG
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      – SubjectFull: Ocular tumors
        Type: general
      – SubjectFull: Retinal diseases
        Type: general
      – SubjectFull: Computer-assisted image analysis (Medicine)
        Type: general
      – SubjectFull: Vision disorders
        Type: general
      – SubjectFull: Microcirculation disorders
        Type: general
      – SubjectFull: Endothelium diseases
        Type: general
      – SubjectFull: Therapeutics
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      – TitleFull: Vascular dysfunctions during radiation retinopathy.
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            NameFull: Niaudet, Colin
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            NameFull: Pham, Thao-Nguyen
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            NameFull: Quintyn, Jean-Claude
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            – D: 01
              M: 01
              Text: Jan2026
              Type: published
              Y: 2026
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              Value: 214
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