Dosimetric evaluation of megavoltage X‐ray and proton minibeam radiation therapy in brain tumor‐bearing canines.
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| Title: | Dosimetric evaluation of megavoltage X‐ray and proton minibeam radiation therapy in brain tumor‐bearing canines. |
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| Authors: | Fernandez‐Rodriguez, Alfredo1,2 (AUTHOR), Perrot, Sébastien3 (AUTHOR), Benoit, Jerôme4 (AUTHOR), Prezado, Yolanda1,2,5,6 (AUTHOR) yolanda.prezado@usc.es |
| Source: | Medical Physics. Dec2025, Vol. 52 Issue 12, p1-10. 10p. |
| Subjects: | Radiotherapy, Brain tumors, Dogs, Medical dosimetry, X-ray imaging, Clinical trials, Proton therapy |
| Abstract: | Background: Healthy tissue toxicity is the main limitation for the treatment of brain tumors using radiotherapy (RT). Megavoltage X‐ray Minibeam Radiation Therapy (MBRT) and proton Minibeam Radiation Therapy (pMBRT) are novel therapeutic approaches demonstrated to reduce healthy tissue toxicity, enhancing the therapeutic possibilities of challenging cases. Owing to the different radiation types delivering the dose, their dosimetric properties may make one approach more suitable than the other depending on tumor type and location. While both techniques have been extensively studied in small animal models, canine clinical studies provide a closer approximation to human conditions. Purpose: This study aims to compare the dosimetric performance of MBRT and pMBRT in canine brain tumors and to determine which modality provides more favorable dose distributions depending on tumor location. Methods: Three representative cases were chosen, and MBRT and pMBRT treatments for a prescribed dose of 26 Gy to the planning target volume (PTV) were simulated using Monte Carlo methods. The in‐depth evolution of the minibeam patterns was investigated for both modalities. The dose distributions within the PTV, healthy brain and surrounding tissues evaluated by calculating and comparing the corresponding peak, valley, and mean doses. Results: pMBRT achieves dosimetric superiority for tumors in the rostral cerebrum surrounded by highly heterogeneous tissue with one entry port. MBRT achieves optimal dose distributions in a two‐beam configuration for deeper and more centered targets, where the reduced lateral spread of X‐ray minibeams preserved dose heterogeneity. Conclusions: In this dosimetric comparison of MBRT and pMBRT for the treatment of spontaneous canine brain tumors, the distinct in‐depth physical behavior of X‐ray and proton minibeams makes each modality more suitable for specific target locations to achieve optimal dose distributions. These findings provide valuable guidance for future veterinary clinical trials and represent an important step toward the clinical implementation of MBRT and pMBRT. [ABSTRACT FROM AUTHOR] |
| Copyright of Medical Physics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 190305297 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Dosimetric evaluation of megavoltage X‐ray and proton minibeam radiation therapy in brain tumor‐bearing canines. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Fernandez‐Rodriguez%2C+Alfredo%22">Fernandez‐Rodriguez, Alfredo</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Perrot%2C+Sébastien%22">Perrot, Sébastien</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Benoit%2C+Jerôme%22">Benoit, Jerôme</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Prezado%2C+Yolanda%22">Prezado, Yolanda</searchLink><relatesTo>1,2,5,6</relatesTo> (AUTHOR)<i> yolanda.prezado@usc.es</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Medical+Physics%22">Medical Physics</searchLink>. Dec2025, Vol. 52 Issue 12, p1-10. 10p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Radiotherapy%22">Radiotherapy</searchLink><br /><searchLink fieldCode="DE" term="%22Brain+tumors%22">Brain tumors</searchLink><br /><searchLink fieldCode="DE" term="%22Dogs%22">Dogs</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+dosimetry%22">Medical dosimetry</searchLink><br /><searchLink fieldCode="DE" term="%22X-ray+imaging%22">X-ray imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Clinical+trials%22">Clinical trials</searchLink><br /><searchLink fieldCode="DE" term="%22Proton+therapy%22">Proton therapy</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Background: Healthy tissue toxicity is the main limitation for the treatment of brain tumors using radiotherapy (RT). Megavoltage X‐ray Minibeam Radiation Therapy (MBRT) and proton Minibeam Radiation Therapy (pMBRT) are novel therapeutic approaches demonstrated to reduce healthy tissue toxicity, enhancing the therapeutic possibilities of challenging cases. Owing to the different radiation types delivering the dose, their dosimetric properties may make one approach more suitable than the other depending on tumor type and location. While both techniques have been extensively studied in small animal models, canine clinical studies provide a closer approximation to human conditions. Purpose: This study aims to compare the dosimetric performance of MBRT and pMBRT in canine brain tumors and to determine which modality provides more favorable dose distributions depending on tumor location. Methods: Three representative cases were chosen, and MBRT and pMBRT treatments for a prescribed dose of 26 Gy to the planning target volume (PTV) were simulated using Monte Carlo methods. The in‐depth evolution of the minibeam patterns was investigated for both modalities. The dose distributions within the PTV, healthy brain and surrounding tissues evaluated by calculating and comparing the corresponding peak, valley, and mean doses. Results: pMBRT achieves dosimetric superiority for tumors in the rostral cerebrum surrounded by highly heterogeneous tissue with one entry port. MBRT achieves optimal dose distributions in a two‐beam configuration for deeper and more centered targets, where the reduced lateral spread of X‐ray minibeams preserved dose heterogeneity. Conclusions: In this dosimetric comparison of MBRT and pMBRT for the treatment of spontaneous canine brain tumors, the distinct in‐depth physical behavior of X‐ray and proton minibeams makes each modality more suitable for specific target locations to achieve optimal dose distributions. These findings provide valuable guidance for future veterinary clinical trials and represent an important step toward the clinical implementation of MBRT and pMBRT. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Medical Physics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/mp.70186 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 10 StartPage: 1 Subjects: – SubjectFull: Radiotherapy Type: general – SubjectFull: Brain tumors Type: general – SubjectFull: Dogs Type: general – SubjectFull: Medical dosimetry Type: general – SubjectFull: X-ray imaging Type: general – SubjectFull: Clinical trials Type: general – SubjectFull: Proton therapy Type: general Titles: – TitleFull: Dosimetric evaluation of megavoltage X‐ray and proton minibeam radiation therapy in brain tumor‐bearing canines. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Fernandez‐Rodriguez, Alfredo – PersonEntity: Name: NameFull: Perrot, Sébastien – PersonEntity: Name: NameFull: Benoit, Jerôme – PersonEntity: Name: NameFull: Prezado, Yolanda IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 12 Text: Dec2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 00942405 Numbering: – Type: volume Value: 52 – Type: issue Value: 12 Titles: – TitleFull: Medical Physics Type: main |
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