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Lung cancer screening with low-dose CT: definition of positive, indeterminate, and negative screen results. A nodule management recommendation from the European Society of Thoracic Imaging.

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Title: Lung cancer screening with low-dose CT: definition of positive, indeterminate, and negative screen results. A nodule management recommendation from the European Society of Thoracic Imaging.
Authors: Snoeckx, Annemiek1,2 (AUTHOR) Annemiek.snoeckx@uza.be, Silva, Mario3 (AUTHOR), Prosch, Helmut4 (AUTHOR), Biederer, Jürgen5,6,7,8 (AUTHOR), Frauenfelder, Thomas9 (AUTHOR), Gleeson, Fergus10 (AUTHOR), Jacobs, Colin11 (AUTHOR), Kauczor, Hans-Ulrich5,6 (AUTHOR), Parkar, Anagha P.12,13 (AUTHOR), Schaefer-Prokop, Cornelia11,14 (AUTHOR), Prokop, Mathias11,15 (AUTHOR) mathias.prokop@radboudumc.nl, Revel, Marie-Pierre16 (AUTHOR)
Source: European Radiology. Jan2026, Vol. 36 Issue 1, p135-147. 13p.
Subjects: Lung cancer, Pulmonary nodules, Medical societies, Early detection of cancer, Computed tomography, Overdiagnosis, Diagnosis, Medical screening
Abstract: Early detection of lung cancer through low-dose CT lung cancer screening in a high-risk population has proven to reduce lung cancer-specific mortality. Nodule management plays a pivotal role in early detection and further diagnostic approaches. The European Society of Thoracic Imaging (ESTI) has established a nodule management recommendation to improve the handling of pulmonary nodules detected during screening. For solid nodules, the primary method for assessing the likelihood of malignancy is to monitor nodule growth using volumetry software. For subsolid nodules, the aggressiveness is determined by measuring the solid part. The ESTI-recommendation enhances existing protocols but puts a stronger focus on lesion aggressiveness. The main goals are to minimise the overall number of follow-up examinations while preventing the risk of a major stage shift and reducing the risk of overtreatment. Key Points: QuestionAssessment of nodule growth and management according to guidelines is essential in lung cancer screening. FindingsAssessment of nodule aggressiveness defines follow-up in lung cancer screening. Clinical relevanceThe ESTI nodule management recommendation aims to reduce follow-up examinations while preventing major stage shift and overtreatment. [ABSTRACT FROM AUTHOR]
Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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  Data: Lung cancer screening with low-dose CT: definition of positive, indeterminate, and negative screen results. A nodule management recommendation from the European Society of Thoracic Imaging.
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  Data: <searchLink fieldCode="JN" term="%22European+Radiology%22">European Radiology</searchLink>. Jan2026, Vol. 36 Issue 1, p135-147. 13p.
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  Data: <searchLink fieldCode="DE" term="%22Lung+cancer%22">Lung cancer</searchLink><br /><searchLink fieldCode="DE" term="%22Pulmonary+nodules%22">Pulmonary nodules</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+societies%22">Medical societies</searchLink><br /><searchLink fieldCode="DE" term="%22Early+detection+of+cancer%22">Early detection of cancer</searchLink><br /><searchLink fieldCode="DE" term="%22Computed+tomography%22">Computed tomography</searchLink><br /><searchLink fieldCode="DE" term="%22Overdiagnosis%22">Overdiagnosis</searchLink><br /><searchLink fieldCode="DE" term="%22Diagnosis%22">Diagnosis</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+screening%22">Medical screening</searchLink>
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  Label: Abstract
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  Data: Early detection of lung cancer through low-dose CT lung cancer screening in a high-risk population has proven to reduce lung cancer-specific mortality. Nodule management plays a pivotal role in early detection and further diagnostic approaches. The European Society of Thoracic Imaging (ESTI) has established a nodule management recommendation to improve the handling of pulmonary nodules detected during screening. For solid nodules, the primary method for assessing the likelihood of malignancy is to monitor nodule growth using volumetry software. For subsolid nodules, the aggressiveness is determined by measuring the solid part. The ESTI-recommendation enhances existing protocols but puts a stronger focus on lesion aggressiveness. The main goals are to minimise the overall number of follow-up examinations while preventing the risk of a major stage shift and reducing the risk of overtreatment. Key Points: QuestionAssessment of nodule growth and management according to guidelines is essential in lung cancer screening. FindingsAssessment of nodule aggressiveness defines follow-up in lung cancer screening. Clinical relevanceThe ESTI nodule management recommendation aims to reduce follow-up examinations while preventing major stage shift and overtreatment. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1007/s00330-025-11648-4
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        Text: English
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      – SubjectFull: Lung cancer
        Type: general
      – SubjectFull: Pulmonary nodules
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      – SubjectFull: Early detection of cancer
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              Text: Jan2026
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