Results from a Swedish model-based analysis of the cost-effectiveness of AI-assisted digital mammography.
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| Title: | Results from a Swedish model-based analysis of the cost-effectiveness of AI-assisted digital mammography. |
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| Authors: | Lyth, Johan1 (AUTHOR), Gialias, Pantelis2,3 (AUTHOR), Husberg, Magnus1 (AUTHOR), Bernfort, Lars1 (AUTHOR), Bjerner, Tomas2,3 (AUTHOR), Wiberg, Maria Kristoffersen2,3 (AUTHOR), Levin, Lars-Åke1 (AUTHOR), Gustafsson, Håkan1,3 (AUTHOR) hakan.l.gustafsson@liu.se |
| Source: | European Radiology. Jan2026, Vol. 36 Issue 1, p754-764. 11p. |
| Subjects: | Cost effectiveness, Quality-adjusted life years, Digital mammography, Early detection of cancer, Swedes, Medical care costs, Markov processes |
| Abstract: | Objective: To evaluate the cost-effectiveness of AI-assisted digital mammography (AI-DM) compared to conventional biennial breast cancer digital mammography screening (cDM) with double reading of screening mammograms, and to investigate the change in cost-effectiveness based on four different sub-strategies of AI-DM. Materials and methods: A decision-analytic state-transition Markov model was used to analyse the decision of whether to use cDM or AI-DM in breast cancer screening. In this Markov model, one-year cycles were used, and the analysis was performed from a healthcare perspective with a lifetime horizon. In the model, we analysed 1000 hypothetical individuals attending mammography screenings assessed with AI-DM compared with 1000 hypothetical individuals assessed with cDM. Results: The total costs, including both screening-related costs and breast cancer-related costs, were €3,468,967 and €3,528,288 for AI-DM and cDM, respectively. AI-DM resulted in a cost saving of €59,320 compared to cDM. Per 1000 individuals, AI-DM gained 10.8 quality-adjusted life years (QALYs) compared to cDM. Gained QALYs at a lower cost means that the AI-DM screening strategy was dominant compared to cDM. Break-even occurred at the second screening at age 42 years. Conclusion: This analysis showed that AI-assisted mammography for biennial breast cancer screening in a Swedish population of women aged 40–74 years is a cost-saving strategy compared to a conventional strategy using double human screen reading. Further clinical studies are needed, as scenario analyses showed that other strategies, more dependent on AI, are also cost-saving. Key Points: QuestionTo evaluate the cost-effectiveness of AI-DM in comparison to conventional biennial breast cDM screening. FindingsAI-DM is cost-effective, and the break-even point occurred at the second screening at age 42 years. Clinical relevanceThe implementation of AI is clearly cost-effective as it reduces the total cost for the healthcare system and simultaneously results in a gain in QALYs. [ABSTRACT FROM AUTHOR] |
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| Database: | Engineering Source |
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