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Solid-phase extraction coupled with liquid chromatography–tandem mass spectrometry for determination of trace rosiglitazone in urine

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Title: Solid-phase extraction coupled with liquid chromatography–tandem mass spectrometry for determination of trace rosiglitazone in urine
Authors: Chou, Chi-Chi1, Lee, Maw-Rong1 mrlee@mail.nchu.edu.tw, Cheng, Fu-Chou2, Yang, Dar-Yu3
Source: Journal of Chromatography A. Dec2005, Vol. 1097 Issue 1/2, p74-83. 10p.
Subjects: Chromatographic analysis, Liquid chromatography, Scission (Chemistry), Atmospheric pressure
Abstract: Abstract: This project evaluated solid-phase extraction (SPE) combined with liquid chromatography–tandem mass spectrometry (LC–MS/MS) to determine the trace amount of rosiglitazone in human urine. The analytical performance of four modes of LC–MS and tandem MS operation (atmospheric pressure chemical ionization (APCI), electrospray ionization (ESI), positive and negative ionization) was compared for two mass spectrometers, a triple-quadrupole and a quadrupole ion trap instrument. Rosiglitazone was extracted from urine using a SPE cartridge of 50mg C8 sorbent and acetonitrile used as the eluting solvent. Samples were then separated on a RP18 column interfaced with a tandem mass spectrometer. The recovery of rosiglitazone was greater than 91.2%. The urine assay combining SPE and LC–APCI-MS/MS of triple-quadrupole was proved a very selective and sensitive method for determination of trace rosiglitazone. The assay was linear over a wide range, with a lower limit of quantification of 0.1ng/mL using 1mL of urine. The intra- and inter-day precisions were <9.8% and <7.9%, respectively, and the accuracies were in the range 91.0–103.6%. The rosiglitazone concentration profile in human urine was also determined. The results of this study reveal the adequacy of SPE–LC–APCI-MS/MS method for analyzing rosiglitazone from diabetic patients’ urines. The concentrations of rosiglitazone were detected to range from 760 to 164pg/mL. [Copyright &y& Elsevier]
Copyright of Journal of Chromatography A is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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DbLabel: Engineering Source
An: 19042640
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  Data: Solid-phase extraction coupled with liquid chromatography–tandem mass spectrometry for determination of trace rosiglitazone in urine
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Chou%2C+Chi-Chi%22&quot;&gt;Chou, Chi-Chi&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Lee%2C+Maw-Rong%22&quot;&gt;Lee, Maw-Rong&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;i&gt; mrlee@mail.nchu.edu.tw&lt;/i&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Cheng%2C+Fu-Chou%22&quot;&gt;Cheng, Fu-Chou&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Yang%2C+Dar-Yu%22&quot;&gt;Yang, Dar-Yu&lt;/searchLink&gt;&lt;relatesTo&gt;3&lt;/relatesTo&gt;
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Journal+of+Chromatography+A%22&quot;&gt;Journal of Chromatography A&lt;/searchLink&gt;. Dec2005, Vol. 1097 Issue 1/2, p74-83. 10p.
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Chromatographic+analysis%22&quot;&gt;Chromatographic analysis&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Liquid+chromatography%22&quot;&gt;Liquid chromatography&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Scission+%28Chemistry%29%22&quot;&gt;Scission (Chemistry)&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Atmospheric+pressure%22&quot;&gt;Atmospheric pressure&lt;/searchLink&gt;
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  Data: Abstract: This project evaluated solid-phase extraction (SPE) combined with liquid chromatography–tandem mass spectrometry (LC–MS/MS) to determine the trace amount of rosiglitazone in human urine. The analytical performance of four modes of LC–MS and tandem MS operation (atmospheric pressure chemical ionization (APCI), electrospray ionization (ESI), positive and negative ionization) was compared for two mass spectrometers, a triple-quadrupole and a quadrupole ion trap instrument. Rosiglitazone was extracted from urine using a SPE cartridge of 50mg C8 sorbent and acetonitrile used as the eluting solvent. Samples were then separated on a RP18 column interfaced with a tandem mass spectrometer. The recovery of rosiglitazone was greater than 91.2%. The urine assay combining SPE and LC–APCI-MS/MS of triple-quadrupole was proved a very selective and sensitive method for determination of trace rosiglitazone. The assay was linear over a wide range, with a lower limit of quantification of 0.1ng/mL using 1mL of urine. The intra- and inter-day precisions were &lt;9.8% and &lt;7.9%, respectively, and the accuracies were in the range 91.0–103.6%. The rosiglitazone concentration profile in human urine was also determined. The results of this study reveal the adequacy of SPE–LC–APCI-MS/MS method for analyzing rosiglitazone from diabetic patients’ urines. The concentrations of rosiglitazone were detected to range from 760 to 164pg/mL. [Copyright &amp;y&amp; Elsevier]
– Name: AbstractSuppliedCopyright
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  Data: &lt;i&gt;Copyright of Journal of Chromatography A is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1016/j.chroma.2005.08.033
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      – Code: eng
        Text: English
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      Pagination:
        PageCount: 10
        StartPage: 74
    Subjects:
      – SubjectFull: Chromatographic analysis
        Type: general
      – SubjectFull: Liquid chromatography
        Type: general
      – SubjectFull: Scission (Chemistry)
        Type: general
      – SubjectFull: Atmospheric pressure
        Type: general
    Titles:
      – TitleFull: Solid-phase extraction coupled with liquid chromatography–tandem mass spectrometry for determination of trace rosiglitazone in urine
        Type: main
  BibRelationships:
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      – PersonEntity:
          Name:
            NameFull: Chou, Chi-Chi
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            NameFull: Lee, Maw-Rong
      – PersonEntity:
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            NameFull: Cheng, Fu-Chou
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            NameFull: Yang, Dar-Yu
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          Dates:
            – D: 02
              M: 12
              Text: Dec2005
              Type: published
              Y: 2005
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              Value: 1097
            – Type: issue
              Value: 1/2
          Titles:
            – TitleFull: Journal of Chromatography A
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